1U7Z
 
 | | Phosphopantothenoylcysteine synthetase from E. coli, 4'-phosphopantothenoyl-CMP complex | | 分子名称: | Coenzyme A biosynthesis bifunctional protein coaBC, PHOSPHORIC ACID MONO-[3-(3-{[5-(4-AMINO-2-OXO-2H-PYRIMIDIN-1-YL)-3,4- DIHYDROXY-TETRAHYDRO-FURAN-2- YLMETHOXY]-HYDROXY-PHOSPHORYLOXY}-3-OXO-PROPYLCARBAMOYL)-3-HYDROXY-2,2- DIMETHYL-PROPYL] ESTER | | 著者 | Stanitzek, S, Augustin, M.A, Huber, R, Kupke, T, Steinbacher, S. | | 登録日 | 2004-08-04 | | 公開日 | 2004-11-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis of CTP-Dependent Peptide Bond Formation in Coenzyme A Biosynthesis Catalyzed by Escherichia coli PPC Synthetase
STRUCTURE, 12, 2004
|
|
3JT4
 | | Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[(3-(ethylsulfanyl)propanimidoyl]-L-ornithine | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, Nitric oxide synthase, ... | | 著者 | Li, H, Poulos, T.L. | | 登録日 | 2009-09-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
|
|
5XYR
 | | Crystal structure of a serine protease from Streptococcus species | | 分子名称: | CALCIUM ION, CHLORIDE ION, Chemokine protease C, ... | | 著者 | Jobichen, C, Sivaraman, J. | | 登録日 | 2017-07-10 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism.
Biochem. J., 475, 2018
|
|
3FE3
 | |
1PTS
 | |
7LWD
 | | Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, ... | | 著者 | Yang, D, Kalenderoglou, I.E, Gouaux, E, Coleman, J.A, Loland, C.J. | | 登録日 | 2021-03-01 | | 公開日 | 2021-08-11 | | 最終更新日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Nat Commun, 12, 2021
|
|
1KLK
 | | CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH | | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE | | 著者 | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Rosowsky, A, Queener, S.F. | | 登録日 | 2001-12-12 | | 公開日 | 2002-12-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.
Acta Crystallogr.,Sect.D, 58, 2002
|
|
8HEV
 | | C12 portal in HCMV B-capsid | | 分子名称: | Portal protein, Unknown peptide | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
|
|
8HEU
 | | C12 portal in HCMV A-capsid | | 分子名称: | Portal protein | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
|
|
5N4S
 | | VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-D-tryptophan (Compound 3) | | 分子名称: | (2~{R})-3-(1~{H}-indol-3-yl)-2-[[(2~{S})-2-methyl-3-sulfanyl-propanoyl]amino]propanoic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | | 著者 | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | | 登録日 | 2017-02-11 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.
Chem. Commun. (Camb.), 53, 2017
|
|
3KW8
 | | Two-domain laccase from Streptomyces coelicolor at 2.3 A resolution | | 分子名称: | COPPER (II) ION, FE (III) ION, Putative copper oxidase, ... | | 著者 | Skalova, T, Dohnalek, J, Kolenko, P, Duskova, J, Stepankova, A, Hasek, J, Ostergaard, L.H, Ostergaard, P.R. | | 登録日 | 2009-12-01 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Structure of laccase from Streptomyces coelicolor after soaking with potassium hexacyanoferrate and at an improved resolution of 2.3 A
Acta Crystallogr.,Sect.F, 67, 2011
|
|
5N4T
 | | VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-L-tryptophan (Compound 4) | | 分子名称: | (2~{S})-3-(1~{H}-indol-3-yl)-2-[[(2~{S})-2-methyl-3-sulfanyl-propanoyl]amino]propanoic acid, BENZOIC ACID, Beta-lactamase VIM-2, ... | | 著者 | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | | 登録日 | 2017-02-11 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition.
Chem. Commun. (Camb.), 53, 2017
|
|
8HEY
 | | One CVSC-binding penton vertex in HCMV B-capsid | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-09 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
|
|
8HEX
 | | C5 portal vertex in HCMV B-capsid | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Major capsid protein, ... | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-08 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
|
|
3G93
 | | Single ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole | | 分子名称: | 1-(biphenyl-4-ylmethyl)-1H-imidazole, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Gay, S.C, Sun, L, Maekawa, K, Halpert, J.R, Stout, C.D. | | 登録日 | 2009-02-12 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
|
|
3JT8
 | | Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-{3-[(1-methylethyl)sulfanyl]propanimidoyl}-L-ornithine | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, Nitric oxide synthase, ... | | 著者 | Li, H, Poulos, T.L. | | 登録日 | 2009-09-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
|
|
3JRT
 | | Structure from the mobile metagenome of V. paracholerae: Integron cassette protein Vpc_cass2 | | 分子名称: | Integron cassette protein Vpc_cass2 | | 著者 | Harrop, S.J, Deshpande, C, Sureshan, V, Boucher, Y, Xu, X, Cui, H, Cuff, M, Edwards, A, Savchenko, A, Joachimiak, A, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2009-09-08 | | 公開日 | 2009-09-22 | | 最終更新日 | 2013-02-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Integron gene cassettes: a repository of novel protein folds with distinct interaction sites.
Plos One, 8, 2013
|
|
1QMR
 | | BIRCH POLLEN ALLERGEN BET V 1 MUTANT N28T, K32Q, E45S, P108G | | 分子名称: | MAJOR POLLEN ALLERGEN BET V 1-A | | 著者 | Henriksen, A, Holm, J.O, Spangfort, M.D, Gajhede, M. | | 登録日 | 1999-10-06 | | 公開日 | 2000-10-12 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses.
J Immunol., 173, 2004
|
|
8EQA
 | |
8EQC
 | |
3PKP
 | | Q83S Variant of S. Enterica RmlA with dATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Glucose-1-phosphate thymidylyltransferase, MAGNESIUM ION | | 著者 | Chang, A, Moretti, R, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2010-11-11 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution.
J.Biol.Chem., 286, 2011
|
|
1MVS
 | | Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase | | 分子名称: | 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, Dihydrofolate Reductase, SULFATE ION | | 著者 | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W.A, Gangjee, A. | | 登録日 | 2002-09-26 | | 公開日 | 2003-04-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 59, 2003
|
|
3PKQ
 | | Q83D Variant of S. Enterica RmlA with dGTP | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, Glucose-1-phosphate thymidylyltransferase, ... | | 著者 | Chang, A, Moretti, R, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2010-11-11 | | 公開日 | 2011-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution.
J.Biol.Chem., 286, 2011
|
|
8I1V
 | | The asymmetric unit of P22 procapsid | | 分子名称: | Major capsid protein, Scaffolding protein | | 著者 | Xiao, H, Liu, H.R, Cheng, L.P. | | 登録日 | 2023-01-13 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures.
Viruses, 15, 2023
|
|
8I1T
 | |
