6AJE
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![BU of 6aje by Molmil](/molmil-images/mine/6aje) | Crystal structure of DHODH in complex with ferulenol from Eimeria tenella | 分子名称: | 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S. | 登録日 | 2018-08-27 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target. Genes (Basel), 11, 2020
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5D30
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2H31
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![BU of 2h31 by Molmil](/molmil-images/mine/2h31) | Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine biosynthesis | 分子名称: | CARBON DIOXIDE, Multifunctional protein ADE2 | 著者 | Li, S.-X, Tong, Y.-P, Xie, X.-C, Li, S.-G, Bi, R.-C. | 登録日 | 2006-05-21 | 公開日 | 2007-01-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis. J.Mol.Biol., 366, 2007
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6OC0
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![BU of 6oc0 by Molmil](/molmil-images/mine/6oc0) | Crystal structure of human DHODH with OSU-03012 | 分子名称: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | 著者 | Durst, M.A, Lavie, A. | 登録日 | 2019-03-21 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol, 27, 2020
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6OC1
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![BU of 6oc1 by Molmil](/molmil-images/mine/6oc1) | Crystal structure of human DHODH with TAK-632 | 分子名称: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | 著者 | Durst, M.A, Lavie, A. | 登録日 | 2019-03-21 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol, 27, 2020
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1THZ
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![BU of 1thz by Molmil](/molmil-images/mine/1thz) | Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening | 分子名称: | 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID, Bifunctional purine biosynthesis protein PURH, POTASSIUM ION | 著者 | Xu, L, Li, C, Olson, A.J, Wilson, I.A. | 登録日 | 2004-06-01 | 公開日 | 2004-09-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J.Biol.Chem., 279, 2004
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3E9K
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![BU of 3e9k by Molmil](/molmil-images/mine/3e9k) | Crystal structure of Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex | 分子名称: | 3-Hydroxyhippuric acid, Kynureninase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Lima, S, Kumar, S, Gawandi, V, Momany, C, Phillips, R.S. | 登録日 | 2008-08-22 | 公開日 | 2008-12-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. J.Med.Chem., 52, 2009
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3ETJ
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![BU of 3etj by Molmil](/molmil-images/mine/3etj) | Crystal structure E. coli Purk in complex with Mg, ADP, and Pi | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HYDROGENPHOSPHATE ION, ... | 著者 | Holden, H.M, Thoden, J.B. | 登録日 | 2008-10-08 | 公開日 | 2008-10-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. Biochemistry, 47, 2008
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3ETH
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![BU of 3eth by Molmil](/molmil-images/mine/3eth) | Crystal structure of E. coli Purk in complex with MgATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Phosphoribosylaminoimidazole carboxylase ATPase subunit | 著者 | Holden, H.M, Thoden, J.B. | 登録日 | 2008-10-08 | 公開日 | 2008-10-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. Biochemistry, 47, 2008
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2EG8
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![BU of 2eg8 by Molmil](/molmil-images/mine/2eg8) | The crystal structure of E. coli dihydroorotase complexed with 5-fluoroorotic acid | 分子名称: | 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, ZINC ION | 著者 | Lee, M, Maher, M.J, Guss, J.M. | 登録日 | 2007-02-28 | 公開日 | 2007-07-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370, 2007
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4Z08
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5VGM
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![BU of 5vgm by Molmil](/molmil-images/mine/5vgm) | Crystal structure of dihydroorotase pyrC from Vibrio cholerae in complex with zinc at 1.95 A resolution. | 分子名称: | ACETATE ION, CHLORIDE ION, Dihydroorotase, ... | 著者 | Lipowska, J, Shabalin, I.G, Miks, C.D, Winsor, J, Cooper, D.R, Shuvalova, L, Kwon, K, Lewinski, K, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-04-11 | 公開日 | 2017-04-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae. Int.J.Biol.Macromol., 136, 2019
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5D2Y
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2EG7
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![BU of 2eg7 by Molmil](/molmil-images/mine/2eg7) | The crystal structure of E. coli dihydroorotase complexed with HDDP | 分子名称: | 2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4,6-DICARBOXYLIC ACID, Dihydroorotase, ZINC ION | 著者 | Lee, M, Maher, M.J, Guss, J.M. | 登録日 | 2007-02-28 | 公開日 | 2007-07-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370, 2007
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2EG6
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5EYT
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![BU of 5eyt by Molmil](/molmil-images/mine/5eyt) | Crystal Structure of Adenylosuccinate Lyase from Schistosoma mansoni in complex with AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase | 著者 | Romanello, L, Torini, J.R, Bird, L, Nettleship, J, Owens, R, Reddivari, Y, Brandao-Neto, J, Pereira, H.M. | 登録日 | 2015-11-25 | 公開日 | 2016-11-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3649 Å) | 主引用文献 | Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL). Mol. Biochem. Parasitol., 214, 2017
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5EYV
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![BU of 5eyv by Molmil](/molmil-images/mine/5eyv) | Crystal Structure of Adenylosuccinate lyase from Schistosoma mansoni in APO form. | 分子名称: | Adenylosuccinate lyase | 著者 | Romanello, L, Torini, J.R, Bird, L.E, Nettleship, J.E, Owens, R.J, Reddivari, Y, Brandao-Neto, J, Pereira, H.M. | 登録日 | 2015-11-25 | 公開日 | 2016-11-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL). Mol. Biochem. Parasitol., 214, 2017
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5G1N
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![BU of 5g1n by Molmil](/molmil-images/mine/5g1n) | Aspartate transcarbamoylase domain of human CAD bound to PALA | 分子名称: | 1,2-ETHANEDIOL, CAD PROTEIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID | 著者 | Ruiz-Ramos, A, Grande-Garcia, A, Moreno-Morcillo, M.D, Ramon-Maiques, S. | 登録日 | 2016-03-29 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala. Structure, 24, 2016
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5G1O
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![BU of 5g1o by Molmil](/molmil-images/mine/5g1o) | Aspartate transcarbamoylase domain of human CAD in apo form | 分子名称: | 1,2-ETHANEDIOL, CAD protein, GLYCEROL | 著者 | Ruiz-Ramos, A, Grande-Garcia, A, Moreno-Morcillo, M.D, Ramon-Maiques, S. | 登録日 | 2016-03-29 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala. Structure, 24, 2016
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5G1P
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![BU of 5g1p by Molmil](/molmil-images/mine/5g1p) | Aspartate transcarbamoylase domain of human CAD bound to carbamoyl phosphate | 分子名称: | CAD PROTEIN, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER | 著者 | Ruiz-Ramos, A, Grande-Garcia, A, Moreno-Morcillo, M.D, Ramon-Maiques, S. | 登録日 | 2016-03-29 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala. Structure, 24, 2016
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1F76
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![BU of 1f76 by Molmil](/molmil-images/mine/1f76) | ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE | 分子名称: | Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ... | 著者 | Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S. | 登録日 | 2000-06-26 | 公開日 | 2002-10-16 | 最終更新日 | 2014-03-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of
dihydroorotate dehydrogenases Structure, 10, 2002
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1LH0
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![BU of 1lh0 by Molmil](/molmil-images/mine/1lh0) | Crystal Structure of Salmonella typhimurium OMP Synthase in Complex with MGPRPP and Orotate | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, OMP synthase, ... | 著者 | Fedorov, A.A, Panneerselvam, K, Shi, W, Grubmeyer, C, Almo, S.C. | 登録日 | 2002-04-16 | 公開日 | 2002-05-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Salmonella typhimurium OMP Synthase in a Complete Substrate Complex. Biochemistry, 51, 2012
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2XYY
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![BU of 2xyy by Molmil](/molmil-images/mine/2xyy) | De Novo model of Bacteriophage P22 procapsid coat protein | 分子名称: | COAT PROTEIN | 著者 | Chen, D.-H, Baker, M.L, Hryc, C.F, DiMaio, F, Jakana, J, Wu, W, Dougherty, M, Haase-Pettingell, C, Schmid, M.F, Jiang, W, Baker, D, King, J.A, Chiu, W. | 登録日 | 2010-11-19 | 公開日 | 2011-02-02 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural Basis for Scaffolding-Mediated Assembly and Maturation of a DsDNA Virus. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Z26
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![BU of 2z26 by Molmil](/molmil-images/mine/2z26) | Thr110Ala dihydroorotase from E. coli | 分子名称: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, MALONATE ION, ... | 著者 | Lee, M, Maher, M.J, Guss, J.M. | 登録日 | 2007-05-17 | 公開日 | 2007-10-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State Biochemistry, 46, 2007
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2Z28
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![BU of 2z28 by Molmil](/molmil-images/mine/2z28) | Thr109Val dihydroorotase from E. coli | 分子名称: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ... | 著者 | Lee, M, Maher, M.J, Guss, J.M. | 登録日 | 2007-05-17 | 公開日 | 2007-10-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State Biochemistry, 46, 2007
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