PDB: 41522 件ウェブページステータス検索Chemie searchBIRD

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3MI7	An Enhanced Repressor of Human Papillomavirus E2 Protein 分子名称: 1,2-ETHANEDIOL, Regulatory protein E2 著者 Bohm, A, Baleja, J, Bose, K, Meinke, G. 登録日 2010-04-09 公開日 2011-04-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design and characterization of an enhanced repressor of human papillomavirus E2 protein. Faseb J., 25, 2011
1NCN	the receptor-binding domain of human B7-2 分子名称: T lymphocyte activation antigen CD86 著者 Zhang, X, Schwartz, J.D, Almo, S.C, Nathenson, S.G. 登録日 2002-12-05 公開日 2003-03-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of the Receptor-Binding Domain of Human B7-2: Insights into Organization and Signaling Proc.Natl.Acad.Sci.USA, 100, 2003
1NDG	Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme 分子名称: ACETIC ACID, Lysozyme C, antibody kappa light chain, ... 著者 Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. 登録日 2002-12-09 公開日 2003-06-03 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 X-ray snapshots of the maturation of an antibody response to a protein antigen Nat.Struct.Biol., 10, 2003
6CQ5	TBK1 in Complex with Sulfone Analog of Amlexanox 分子名称: 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2018-03-14 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.354 Å) 主引用文献 Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26, 2018
4LHB	Crystal structure of tungsten cofactor synthesizing protein MoaB from Pyrococcus furiosus 分子名称: Molybdopterin adenylyltransferase, SULFATE ION 著者 Havarushka, N, Schwarz, G. 登録日 2013-07-01 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis of Thermal Stability of the Tungsten Cofactor Synthesis Protein MoaB from Pyrococcus furiosus. Plos One, 9, 2014
4NBN	Tailoring Small Molecules for an Allosteric Site on Procaspase-6 分子名称: 2,2'-[pyrimidine-4,6-diylbis(iminomethanediyl)]diphenol, Caspase-6, PHOSPHATE ION 著者 Murray, J.M, Steffek, M. 登録日 2013-10-23 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
4N5D	Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 6-amino-2,8-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one, Caspase-6, ... 著者 Murray, J.M, Steffek, M. 登録日 2013-10-09 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
6CQ4	TBK1 in Complex with Cyclohexyl Analog of Amlexanox 分子名称: 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2018-03-14 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26, 2018
3RMZ	Crystal Structure of the W199F-MauG/pre-Methylamine Dehydrogenase Complex 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, ... 著者 Jensen, L.M.R, Wilmot, C.M. 登録日 2011-04-21 公開日 2011-10-05 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis. Proc.Natl.Acad.Sci.USA, 108, 2011
4COO	Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution 分子名称: 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ACETATE ION, ... 著者 McCorvie, T.J, Kopec, J, Vollamar, M, Strain-Damerell, C, Bushell, S, Bradley, A, Tallant, C, Kiyani, W, Froese, D.S, Carpenter, E.S, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. 登録日 2014-01-29 公開日 2014-03-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation. J.Biol.Chem., 289, 2014
6BNY	TBK1 in complex with tetrazole analog of amlexanox 分子名称: 2-amino-7-(propan-2-yl)-3-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-one, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2017-11-17 公開日 2018-09-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.341 Å) 主引用文献 Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94, 2018
2WKT	BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX OF THE N316A MUTANT WITH COENZYME A. 分子名称: ACETYL-COA ACETYLTRANSFERASE, CHLORIDE ION, COENZYME A, ... 著者 Merilainen, G, Poikela, V, Kursula, P, Wierenga, R.K. 登録日 2009-06-18 公開日 2009-11-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Thiolase Reaction Mechanism: The Importance of Asn316 and His348 for Stabilizing the Enolate Intermediate of the Claisen Condensation. Biochemistry, 48, 2009
3RV3	Crystal structure of E.coli biotin carboxylase in complex with two ADP and one Mg ion 分子名称: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, MAGNESIUM ION 著者 Chou, C.Y, Tong, L. 登録日 2011-05-05 公開日 2011-05-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization. J.Biol.Chem., 286, 2011
3FSR	Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T. brockii ADH by C. beijerinckii ADH 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, NADP-dependent alcohol dehydrogenase, ... 著者 Frolow, F, Greenblatt, H, Goihberg, E, Burstein, Y. 登録日 2009-01-11 公開日 2010-01-19 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms Biochemistry, 49, 2010
4R9H	Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 Angstrom resolution 分子名称: Beta-2-microglobulin 著者 Halabelian, L, Bolognesi, M, Ricagno, S. 登録日 2014-09-05 公開日 2015-09-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A covalent homodimer probing early oligomers along amyloid aggregation. Sci Rep, 5, 2015
4EP5	Thermus thermophilus RuvC structure 分子名称: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, SULFATE ION 著者 Chen, L, Shi, K, Yin, Z.Q, Aihara, H. 登録日 2012-04-17 公開日 2012-11-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution. Nucleic Acids Res., 41, 2013
6CQ0	TBK1 in Complex with Dimethyl Amino Analog of Amlexanox 分子名称: 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2018-03-14 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26, 2018
3FTN	Q165E/S254K Double Mutant Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T. brockii ADH by C. beijerinckii ADH 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... 著者 Frolow, F, Goihberg, E, Shimon, L, Burstein, Y. 登録日 2009-01-13 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.192 Å) 主引用文献 Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms. Biochemistry, 49, 2010
1NH9	Crystal Structure of a DNA Binding Protein Mja10b from the hyperthermophile Methanococcus jannaschii 分子名称: DNA-binding protein Alba 著者 Wang, G, Bartlam, M, Guo, R, Yang, H, Xue, H, Liu, Y, Huang, L, Rao, Z. 登録日 2002-12-19 公開日 2003-12-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschii Protein Sci., 12, 2003
2CG8	The bifunctional dihydroneopterin aldolase 6-hydroxymethyl-7,8- dihydropterin synthase from Streptococcus pneumoniae 分子名称: DIHYDRONEOPTERIN ALDOLASE 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN SYNTHASE 著者 Garcon, A, Levy, C, Derrick, J.P. 登録日 2006-02-28 公開日 2006-06-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of the Bifunctional Dihydroneopterin Aldolase/6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Streptococcus Pneumoniae. J.Mol.Biol., 360, 2006
4RAH	Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.4 Angstrom resolution 分子名称: Beta-2-microglobulin 著者 Halabelian, L, Bolognesi, M, Ricagno, S. 登録日 2014-09-10 公開日 2015-09-16 最終更新日 2015-11-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A covalent homodimer probing early oligomers along amyloid aggregation. Sci Rep, 5, 2015
1NDM	Crystal structure of Fab fragment of antibody HyHEL-26 complexed with lysozyme 分子名称: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain 著者 Mariuzza, R.A, Li, Y, Li, H. 登録日 2002-12-09 公開日 2003-06-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray snapshots of the maturation of an antibody response to a protein antigen Nat.Struct.Biol., 10, 2003
3MFC	Computationally designed end0-1,4-beta,xylanase 分子名称: Endo-1,4-beta-xylanase, SULFATE ION 著者 Morin, A, Harp, J.M. 登録日 2010-04-01 公開日 2010-11-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Computational design of an endo-1,4-{beta}-xylanase ligand binding site. Protein Eng.Des.Sel., 24, 2011
3MF6	Computationally designed endo-1,4-beta-xylanase 分子名称: Endo-1,4-beta-xylanase, SULFATE ION 著者 Morin, A, Harp, J.M. 登録日 2010-04-01 公開日 2010-11-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Computational design of an endo-1,4-{beta}-xylanase ligand binding site. Protein Eng.Des.Sel., 24, 2011
3PCX	Caspase-3 E246A, K242A Double Mutant 分子名称: Caspase-3, Inhibitor Ac-DEVD-CMK 著者 Walters, J, Swartz, P, Mattos, C, Clark, A.C. 登録日 2010-10-22 公開日 2011-02-23 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508, 2011

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