4J1P
 
 | | X-ray crystal structure of bromodomain 2 of human brd2 in complex with rvx208 to 1.08 A resolution | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain containing 2, ... | | 著者 | Stein, A.J, White, A, Suto, R.K. | | 登録日 | 2013-02-01 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist.
Plos One, 8, 2013
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6VN7
 | | Cryo-EM structure of an activated VIP1 receptor-G protein complex | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. | | 登録日 | 2020-01-29 | | 公開日 | 2020-09-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.
Nat Commun, 11, 2020
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7BG0
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7BO6
 | | VDR complex with LCA derivative | | 分子名称: | (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | 著者 | Rochel, N. | | 登録日 | 2021-01-24 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Lithocholic acid-based design of noncalcemic vitamin D receptor agonists.
Bioorg.Chem., 111, 2021
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5FBE
 | | COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND2 | | 分子名称: | Complement factor D, GLYCEROL, methyl 2-[[[(2~{S})-2-[[3-(trifluoromethyloxy)phenyl]carbamoyl]pyrrolidin-1-yl]carbonylamino]methyl]benzoate | | 著者 | Ostermann, N, Zink, F. | | 登録日 | 2015-12-14 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat.Chem.Biol., 12, 2016
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5U57
 | | Psf4 in complex with Fe2+ and (S)-2-HPP | | 分子名称: | (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, (S)-2-hydroxypropylphosphonic acid epoxidase, FE (III) ION | | 著者 | Chekan, J.R, Nair, S.K. | | 登録日 | 2016-12-06 | | 公開日 | 2017-01-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.
ACS Chem. Biol., 12, 2017
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5FCE
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6VI0
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6VJA
 | | Structure of CD20 in complex with rituximab Fab | | 分子名称: | B-lymphocyte antigen CD20, CHOLESTEROL HEMISUCCINATE, Rituximab Fab heavy chain, ... | | 著者 | Rohou, A, Croll, T.I. | | 登録日 | 2020-01-15 | | 公開日 | 2020-02-26 | | 最終更新日 | 2020-03-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab.
Science, 367, 2020
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4IU1
 | | Crystal structure of Leishmania mexicana arginase in complex with inhibitor nor-NOHA | | 分子名称: | Arginase, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | D'Antonio, E.L, Ullman, B, Roberts, S.C, Gaur Dixit, U, Wilson, M.E, Hai, Y, Christianson, D.W. | | 登録日 | 2013-01-19 | | 公開日 | 2013-01-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Arch.Biochem.Biophys., 535, 2013
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4J27
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5U7R
 | | Identification of A New Class of Potent Cdc7 Inhibitors Designed by Putative Pharmacophore Model: Synthesis and Biological Evaluation of 2,3-Dihydrothieno[3,2-d]pyrimidin-4(1H)-ones | | 分子名称: | (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one, Rho-associated protein kinase 2 | | 著者 | Hoffman, I.D, Skene, R.J. | | 登録日 | 2016-12-12 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg. Med. Chem., 25, 2017
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8G82
 | | Vancomycin bound to D-Ala-D-Ser | | 分子名称: | BORIC ACID, D-Ala-D-Ser, DIMETHYL SULFOXIDE, ... | | 著者 | Loll, P.J, Park, J.H. | | 登録日 | 2023-02-17 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Crystal structure of vancomycin bound to the resistance determinant D-alanine-D-serine.
Iucrj, 11, 2024
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7BMS
 | | HEWL in cesium chloride (1.5 M CsCl in crystallization condition and cryo protectant) | | 分子名称: | 1,2-ETHANEDIOL, CESIUM ION, CHLORIDE ION, ... | | 著者 | Koelmel, W, Kuper, J, Kisker, C. | | 登録日 | 2021-01-20 | | 公開日 | 2021-10-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Sci Rep, 11, 2021
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7BMW
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7BMO
 | | HEWL in cesium chloride (0.25 M CsCl in protein buffer) | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Hen egg white lysozyme, ... | | 著者 | Koelmel, W, Kuper, J, Kisker, C. | | 登録日 | 2021-01-20 | | 公開日 | 2021-10-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Sci Rep, 11, 2021
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8GC8
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7BMP
 | | HEWL in cesium chloride (0.25 M CsCl in protein buffer and cryo protectant). | | 分子名称: | 1,2-ETHANEDIOL, CESIUM ION, CHLORIDE ION, ... | | 著者 | Koelmel, W, Kuper, J, Kisker, C. | | 登録日 | 2021-01-20 | | 公開日 | 2021-10-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Sci Rep, 11, 2021
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7BMU
 | | p62PH in cesium chloride (0.25 M CsCl in protein buffer) | | 分子名称: | CESIUM ION, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Koelmel, W, Kuper, J, Kisker, C. | | 登録日 | 2021-01-20 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Sci Rep, 11, 2021
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5UCH
 | | Hsp90b N-terminal domain with inhibitors | | 分子名称: | 2-(5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylphenyl)acetonitrile, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Peng, S, Balch, M, Matts, R, Deng, J. | | 登録日 | 2016-12-22 | | 公開日 | 2018-01-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.654 Å) | | 主引用文献 | Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
Nat Commun, 9, 2018
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7BMX
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8GC7
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7BMZ
 | | p62PH in potassium chloride | | 分子名称: | CHLORIDE ION, POTASSIUM ION, RNA polymerase II transcription factor B 73 kDa subunit-like protein | | 著者 | Koelmel, W, Kuper, J, Kisker, C. | | 登録日 | 2021-01-20 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Sci Rep, 11, 2021
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7BMR
 | | HEWL in cesium chloride (0.25 M CsCl in protein buffer and 1.71 M CsCl in cryo protectant) | | 分子名称: | 1,2-ETHANEDIOL, CESIUM ION, CHLORIDE ION, ... | | 著者 | Koelmel, W, Kuper, J, Kisker, C. | | 登録日 | 2021-01-20 | | 公開日 | 2021-10-06 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Sci Rep, 11, 2021
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7BMV
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