5U7R
Identification of A New Class of Potent Cdc7 Inhibitors Designed by Putative Pharmacophore Model: Synthesis and Biological Evaluation of 2,3-Dihydrothieno[3,2-d]pyrimidin-4(1H)-ones
Summary for 5U7R
Entry DOI | 10.2210/pdb5u7r/pdb |
Related | 5U7Q |
Descriptor | Rho-associated protein kinase 2, (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one (3 entities in total) |
Functional Keywords | serine/threonine kinase, apo-protein, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: O75116 |
Total number of polymer chains | 4 |
Total formula weight | 183316.50 |
Authors | Hoffman, I.D.,Skene, R.J. (deposition date: 2016-12-12, release date: 2017-03-29, Last modification date: 2024-03-06) |
Primary citation | Kurasawa, O.,Oguro, Y.,Miyazaki, T.,Homma, M.,Mori, K.,Iwai, K.,Hara, H.,Skene, R.,Hoffman, I.,Ohashi, A.,Yoshida, S.,Ishikawa, T.,Cho, N. Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones. Bioorg. Med. Chem., 25:2133-2147, 2017 Cited by PubMed: 28284870DOI: 10.1016/j.bmc.2017.02.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.33 Å) |
Structure validation
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