7BO6

VDR complex with LCA derivative

Summary for 7BO6

• Entry DOI: 10.2210/pdb7bo6/pdb
• Descriptor: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid, ... (4 entities in total)
• Functional Keywords: nuclear receptor, agonist, transcription
• Biological source: Danio rerio (Zebrafish); More
• Total number of polymer chains: 2
• Total formula weight: 36269.42

Authors

Rochel, N. (deposition date: 2021-01-24, release date: 2021-08-11, Last modification date: 2024-01-31)

• Primary citation: Gaikwad, S.,Gonzalez, C.M.,Vilarino, D.,Lasanta, G.,Villaverde, C.,Mourino, A.,Verlinden, L.,Verstuyf, A.,Peluso-Iltis, C.,Rochel, N.,Berkowska, K.,Marcinkowska, E.; Lithocholic acid-based design of noncalcemic vitamin D receptor agonists.; Bioorg.Chem., 111:104878-104878, 2021; PubMed: 33853023; DOI: 10.1016/j.bioorg.2021.104878

Experimental method

X-RAY DIFFRACTION (2.86 Å)