PDB: 46984 件ウェブページステータス検索Chemie searchBIRD

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3KA2	Crystal structure of chemically synthesized 203 amino acid 'covalent dimer' [L-Ala;Gly51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.4 A resolution 分子名称: N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, [L-Ala51;Gly51']HIV-1 protease 著者 Torbeev, V.Y, Kent, S.B.H. 登録日 2009-10-18 公開日 2011-04-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
3JBV	Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps 分子名称: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... 著者 Zhang, J, Pan, X.J, Yan, K.G, Sun, S, Gao, N, Sui, S.F. 登録日 2015-10-16 公開日 2016-01-27 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Mechanisms of ribosome stalling by SecM at multiple elongation steps Elife, 4, 2015
3JCP	Structure of yeast 26S proteasome in M2 state derived from Titan dataset 分子名称: 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... 著者 Luan, B, Huang, X.L, Wu, J.P, Shi, Y.G, Wang, F. 登録日 2016-01-06 公開日 2016-06-15 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proc.Natl.Acad.Sci.USA, 113, 2016
2AF5	2.5A X-ray Structure of Engineered OspA protein 分子名称: Engineered Outer Surface Protein A (OspA) with the inserted two beta-hairpins 著者 Makabe, K, Mcelheny, D, Tereshko, V, Hilyard, A, Koide, A, Koide, S. 登録日 2005-07-25 公開日 2006-08-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Atomic structures of peptide self-assembly mimics. Proc.Natl.Acad.Sci.Usa, 103, 2006
3J79	Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W. 登録日 2014-06-02 公開日 2014-07-16 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife, 3, 2014
5XHJ	Crystal Structure of P450BM3 with 5-Cyclohexylvaleroyl-L-Tryptophan 分子名称: 5-cyclohexylpentanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Suzuki, K, Shoji, O, Stanfield, J.K, Kasai, C, Sugimoto, H, Shiro, Y, Watanabe, Y. 登録日 2017-04-21 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Control of stereoselectivity of benzylic hydroxylation catalysed by wild-type cytochrome P450BM3 using decoy molecules CATALYSIS SCIENCE AND TECHNOLOGY, 7, 2017
1ZYR	Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ... 著者 Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. 登録日 2005-06-10 公開日 2005-09-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell(Cambridge,Mass.), 122, 2005
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. 登録日 2017-04-28 公開日 2017-12-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.004 Å) 主引用文献 A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
2A19	PKR kinase domain- eIF2alpha- AMP-PNP complex. 分子名称: Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase, ... 著者 Dar, A.C, Dever, T.E, Sicheri, F. 登録日 2005-06-19 公開日 2005-09-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR. Cell(Cambridge,Mass.), 122, 2005
4DQC	Crystal Structure of (G16C/L38C) HIV-1 Protease in Complex with DRV 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Aspartyl protease, GLYCEROL, ... 著者 Schiffer, C.A, Mittal, S. 登録日 2012-02-15 公開日 2012-03-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134, 2012
2A47	Crystal structure of amFP486 H199T 分子名称: BETA-MERCAPTOETHANOL, GFP-like fluorescent chromoprotein amFP486 著者 Henderson, J.N, Remington, S.J. 登録日 2005-06-28 公開日 2005-08-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal structures and mutational analysis of amFP486, a cyan fluorescent protein from Anemonia majano Proc.Natl.Acad.Sci.Usa, 102, 2005
4DVQ	Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone 分子名称: Cytochrome P450 11B2, mitochondrial, DESOXYCORTICOSTERONE, ... 著者 Strushkevich, N, Shen, L, Tempel, W, Arrowsmith, C, Edwards, A, Usanov, S.A, Park, H.-W. 登録日 2012-02-23 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Mol.Endocrinol., 27, 2013
2AAD	THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT 分子名称: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 ISOZYME 著者 Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. 登録日 1992-09-15 公開日 1994-01-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. Biochemistry, 31, 1992
2ACP	Crystal structure of nitrophorin 2 aqua complex 分子名称: Nitrophorin 2, PROTOPORPHYRIN IX CONTAINING FE 著者 Weichsel, A, Berry, R.E, Walker, F.A, Montfort, W.R. 登録日 2005-07-19 公開日 2006-06-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structures, ligand induced conformational change and heme deformation in complexes of nitrophorin 2, a nitric oxide transport protein from rhodnius prolixus To be Published
4DWP	SeMet protelomerase tela covalently complexed with substrate DNA 分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*TP*AP*TP*TP*GP*TP*TP*AP*TP*TP*GP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*AP*CP*AP*AP*TP*AP*AP*CP*AP*AP*TP*AP*T)-3'), Protelomerase, ... 著者 Shi, K, Aihara, H. 登録日 2012-02-26 公開日 2013-02-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 An enzyme-catalyzed multistep DNA refolding mechanism in hairpin telomere formation. Plos Biol., 11, 2013
1ZX9	Crystal Structure of Tn501 MerA 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Mercuric reductase 著者 Dong, A, Ledwidge, R, Patel, B, Fiedler, D, Falkowski, M, Zelikova, J, Summers, A.O, Pai, E.F, Miller, S.M. 登録日 2005-06-07 公開日 2005-07-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions Biochemistry, 44, 2005
4DHV	Crystal structure of the Pyrococcus furiosus ferredoxin D14C variant containing the heterometallic [AgFe3S4] cluster 分子名称: COBALT HEXAMMINE(III), Ferredoxin, SILVER/IRON/SULFUR CLUSTER 著者 Jakab-Simon, I.N, Christensen, H.E.M, Haahr, L.T. 登録日 2012-01-30 公開日 2013-01-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Heterometallic [AgFe(3)S (4)] ferredoxin variants: synthesis, characterization, and the first crystal structure of an engineered heterometallic iron-sulfur protein. J.Biol.Inorg.Chem., 18, 2013
2AAZ	Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase 著者 Finer-Moore, J.S, Anderson, A.C, O'Neil, R.H, Costi, M.P, Ferrari, S, Krucinski, J, Stroud, R.M. 登録日 2005-07-14 公開日 2005-12-06 最終更新日 2018-02-14 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr.,Sect.D, 61, 2005
1ZZ5	Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative 分子名称: 13,15-DIAMINO-2-(AMINOMETHYL)-3,4,9,12-TETRAHYDROXYHEXADECAHYDRO-2H-7,10-EPOXYPYRANO[2,3-B][1,10,4]BENZODIOXAZACYCLODODECIN-8-YL 2,6-DIAMINO-2,6-DIDEOXYHEXOPYRANOSIDE, 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3', 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3', ... 著者 Zhao, Q, Zhao, F, Blount, K.F, Han, Q, Tor, Y, Hermann, T. 登録日 2005-06-13 公開日 2005-09-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Molecular recognition of RNA by neomycin and a restricted neomycin derivative Angew.Chem.Int.Ed.Engl., 44, 2005
6YMT	RNASE 3/1 version1 分子名称: GLYCEROL, RNase 3/1 version 1 著者 Fernandez-Millan, P, Prats-Ejarque, G, Vazquez-Monteagudo, S, Boix, E. 登録日 2020-04-09 公開日 2021-07-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Exploring the RNase A scaffold to combine catalytic and antimicrobial activities. Structural characterization of RNase 3/1 chimeras. Front Mol Biosci, 9, 2022
3LEL	Structural Insight into the Sequence-Dependence of Nucleosome Positioning 分子名称: 147-MER DNA, Histone H2A, Histone H2B 1.1, ... 著者 Wu, B, Vasudevan, D, Davey, C.A. 登録日 2010-01-15 公開日 2010-05-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural insight into the sequence dependence of nucleosome positioning Structure, 18, 2010
8WAK	Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS. 分子名称: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... 著者 Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. 登録日 2023-09-07 公開日 2023-12-06 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (5.47 Å) 主引用文献 Structural visualization of transcription initiation in action. Science, 382, 2023
8WAR	Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II positioned 8nt downstream of TSS. 分子名称: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... 著者 Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. 登録日 2023-09-08 公開日 2023-12-06 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (7.2 Å) 主引用文献 Structural visualization of transcription initiation in action. Science, 382, 2023
6X91	Crystal structure of MBP-fused human APOBEC1 分子名称: CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ... 著者 Wolfe, A.D, Li, S.-X, Chen, X.S. 登録日 2020-06-02 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.51 Å) 主引用文献 The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. NAR Cancer, 2, 2020
6I1L	Crystal structure of FnCas12a in complex with a crRNA guide and ssDNA target 分子名称: CITRIC ACID, CRISPR-associated endonuclease Cas12a, MAGNESIUM ION, ... 著者 Jinek, M, Swarts, D.C. 登録日 2018-10-29 公開日 2019-01-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a. Mol. Cell, 73, 2019

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