4DVQ

Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone

Summary for 4DVQ

Entry DOI	10.2210/pdb4dvq/pdb
Descriptor	Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, DESOXYCORTICOSTERONE, ... (5 entities in total)
Functional Keywords	cytochrome p450, cyp11b2, aldosterone synthase, monooxygenase, heme protein, mineralocorticoid, corticosteroid, mitochondria, membrane, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion membrane: P19099
Total number of polymer chains	12
Total formula weight	680021.94
Authors	Strushkevich, N.,Shen, L.,Tempel, W.,Arrowsmith, C.,Edwards, A.,Usanov, S.A.,Park, H.-W. (deposition date: 2012-02-23, release date: 2013-01-30, Last modification date: 2024-02-28)
Primary citation	Strushkevich, N.,Gilep, A.A.,Shen, L.,Arrowsmith, C.H.,Edwards, A.M.,Usanov, S.A.,Park, H.W. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Mol.Endocrinol., 27:315-324, 2013 Cited by PubMed: 23322723 DOI: 10.1210/me.2012-1287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation