4DVQ
Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Cytochrome P450 11B2, mitochondrial | polymer | 483 | 55649.5 | 12 | UniProt (P19099) Pfam (PF00067) | Homo sapiens (human) | Aldosterone synthase, ALDOS, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Steroid 18-hydroxylase |
| 2 | BA, EA, HA, JA, LA... (F, G, H, I, J...) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 12 | Chemie (HEM) | |||
| 3 | CA, FA, IA, KA, MA... (F, G, H, I, J...) | DESOXYCORTICOSTERONE | non-polymer | 330.5 | 12 | Chemie (1CA) PubChem (18530239) PubChem (6166) PubChem (23902378) PubChem (23955946) PubChem (40543501) PubChem (44135506) PubChem (44659452) PubChem (23900052) PubChem (51578076) PubChem (40543496) PubChem (223578) PubChem (667475) PubChem (73707523) PubChem (1403452) PubChem (1403453) PubChem (1403454) PubChem (657194) PubChem (5316556) PubChem (6604197) PubChem (6984615) PubChem (124303801) PubChem (124506965) PubChem (12303995) PubChem (124770616) PubChem (154559530) PubChem (124917358) PubChem (162968029) PubChem (129162682) | |||
| 4 | AA, DA, GA, O, PA... (E, F, G, A, K...) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 5 | AB, BB, CB, DB, EB... (H, I, J, K, L...) | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 34 - 503 (UniProt: P19099)
| PDB | External Database | Details |
|---|---|---|
| Met 27 | - | expression tag |
| Ala 28 | - | expression tag |
| Lys 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Thr 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Ser 33 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
| His 508 | - | expression tag |
| His 509 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 667794.0 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 12227.9 | |
| All* | Total formula weight | 680021.9 |
