4DVQ
Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Cytochrome P450 11B2, mitochondrial | polymer | 483 | 55649.5 | 12 | UniProt (P19099) Pfam (PF00067) In PDB | Homo sapiens (human) | Aldosterone synthase, ALDOS, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Steroid 18-hydroxylase |
2 | F, G, H, I, J... | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 12 | Chemie (HEM) | |||
3 | F, G, H, I, J... | DESOXYCORTICOSTERONE | non-polymer | 330.5 | 12 | Chemie (1CA) | |||
4 | E, F, G, A, K... | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
5 | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 34 - 503 (UniProt: P19099)
PDB | External Database | Details |
---|---|---|
Met 27 | - | expression tag |
Ala 28 | - | expression tag |
Lys 29 | - | expression tag |
Lys 30 | - | expression tag |
Thr 31 | - | expression tag |
Ser 32 | - | expression tag |
Ser 33 | - | expression tag |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
His 508 | - | expression tag |
His 509 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 667794.0 | |
Non-Polymers* | Number of molecules | 33 |
Total formula weight | 12227.9 | |
All* | Total formula weight | 680021.9 |