7Q3X
 
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6MV8
 
 | LDHA structure in complex with inhibitor 14 | 分子名称: | (6S)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(2-hydroxyphenyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Eigenbrot, C.E, Ultsch, M, Wei, B. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-based Optimization of Potent, Cell-Active
Hydroxylactam Inhibitors of Lactate Dehydrogenase To Be Published
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3LDH
 
 | A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID | 著者 | White, J.L, Hackert, M.L, Buehner, M, Adams, M.J, Ford, G.C, Lentzjunior, P.J, Smiley, I.E, Steindel, S.J, Rossmann, M.G. | 登録日 | 1974-06-06 | 公開日 | 1977-04-29 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. J.Mol.Biol., 102, 1976
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6CEP
 
 | Sus scrofa heart L-lactate dehydrogenase ternary complex with NADH and oxamate | 分子名称: | L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID | 著者 | Hoffer, E.D, Andrews, B, Dunham, C.M, Dyer, R.B. | 登録日 | 2018-02-12 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase. Medchemcomm, 9, 2018
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8J5D
 
 | Cryo-EM structure of starch degradation complex of BAM1-LSF1-MDH | 分子名称: | Beta-amylase 1, chloroplastic, Malate dehydrogenase, ... | 著者 | Guan, Z.Y, Liu, J, Yan, J.J. | 登録日 | 2023-04-21 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The LIKE SEX FOUR 1-malate dehydrogenase complex functions as a scaffold to recruit beta-amylase to promote starch degradation. Plant Cell, 36, 2023
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9FQR
 
 | 96-nm repeat of axonemal doublet microtubules from bovine sperm | 分子名称: | A-kinase anchoring protein 14, ATP6V1F neighbor, Actin, ... | 著者 | Leung, M.R, Sun, C, Zeng, J, Anderson, J.R, Niu, Q, Huang, W, Noteborn, W.E.M, Brown, A, Zeev-Ben-Mordehai, T, Zhang, R. | 登録日 | 2024-06-21 | 公開日 | 2025-03-26 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Structural diversity of axonemes across mammalian motile cilia. Nature, 637, 2025
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6ZZR
 
 | The Crystal Structure of human LDHA from Biortus. | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, L-lactate dehydrogenase A chain | 著者 | Wang, F, Lin, D, Cheng, W, Bao, X, Zhu, B, Shang, H. | 登録日 | 2020-08-05 | 公開日 | 2020-08-19 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The Crystal Structure of human LDHA from Biortus To Be Published
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6MVA
 
 | LDHA structure in complex with inhibitor 14 | 分子名称: | (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Eigenbrot, C.E, Ultsch, M, Wei, B. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structure-based Optimization of Potent, Cell-Active
Hydroxylactam Inhibitors of Lactate Dehydrogenase To Be Published
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4ZVV
 
 | Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 | 分子名称: | (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Li, Y, Chen, Z, Eigenbrot, C. | 登録日 | 2015-05-18 | 公開日 | 2016-05-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol., 12, 2016
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8XKV
 
 | Cryo-EM structure of the Ycf2-FtsHi motor complex from Arabidopsis in Apo state | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ATP-dependent zinc metalloprotease FTSH 12, chloroplastic, ... | 著者 | Liang, K, Zhan, X, Xu, Q, Wu, J, Yan, Z. | 登録日 | 2023-12-25 | 公開日 | 2024-09-11 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into the chloroplast protein import in land plants. Cell, 187, 2024
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8XKU
 
 | Cryo-EM structure of the Ycf2-FtsHi motor complex from Arabidopsis in ATP-bound state | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent zinc metalloprotease FTSH 12, ... | 著者 | Liang, K, Zhan, X, Xu, Q, Wu, J, Yan, Z. | 登録日 | 2023-12-24 | 公開日 | 2024-09-11 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into the chloroplast protein import in land plants. Cell, 187, 2024
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8LDH
 
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8QDE
 
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8Q3C
 
 | Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant | 分子名称: | CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ... | 著者 | Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D. | 登録日 | 2023-08-03 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
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2ZQY
 
 | T-state structure of allosteric L-lactate dehydrogenase from Lactobacillus casei | 分子名称: | L-lactate dehydrogenase, NITRATE ION | 著者 | Arai, K, Ishimitsu, T, Fushinobu, S, Uchikoba, H, Matsuzawa, H, Taguchi, H. | 登録日 | 2008-08-22 | 公開日 | 2009-09-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Active and inactive state structures of unliganded Lactobacillus casei allosteric L-lactate dehydrogenase. Proteins, 78, 2010
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3NEP
 
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2V6B
 
 | Crystal structure of lactate dehydrogenase from Deinococcus Radiodurans (apo form) | 分子名称: | L-LACTATE DEHYDROGENASE | 著者 | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | 登録日 | 2007-07-16 | 公開日 | 2007-09-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments. J. Mol. Biol., 374, 2007
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1PZE
 
 | T.gondii LDH1 apo form | 分子名称: | lactate dehydrogenase | 著者 | Kavanagh, K.L, Elling, R.A, Wilson, D.K. | 登録日 | 2003-07-10 | 公開日 | 2004-02-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use. Biochemistry, 43, 2004
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1PZF
 
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1PZH
 
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1PZG
 
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3TL2
 
 | Crystal structure of Bacillus anthracis str. Ames malate dehydrogenase in closed conformation. | 分子名称: | 1,2-ETHANEDIOL, Malate dehydrogenase, THIOCYANATE ION | 著者 | Blus, B.J, Chruszcz, M, Tkaczuk, K.L, Osinski, T, Cymborowski, M, Kudritska, M, Grimshaw, S, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-08-29 | 公開日 | 2011-09-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of Bacillus anthracis str. Ames malate dehydrogenase in closed conformation. TO BE PUBLISHED
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2V65
 
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2V6M
 
 | Crystal structure of lactate dehydrogenase from Thermus Thermophilus HB8 (Apo form) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, L-LACTATE DEHYDROGENASE | 著者 | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | 登録日 | 2007-07-19 | 公開日 | 2007-09-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments. J. Mol. Biol., 374, 2007
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2V7P
 
 | Crystal structure of lactate dehydrogenase from Thermus Thermophilus HB8 (Holo form) | 分子名称: | L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID | 著者 | Coquelle, N, Fioravanti, E, Weik, M, Vellieux, F. | 登録日 | 2007-07-31 | 公開日 | 2007-09-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments. J. Mol. Biol., 374, 2007
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