PDB: 205 件ウェブページステータス検索Chemie searchBIRD

---

1RXM	C-terminal region of FEN-1 bound to A. fulgidus PCNA 分子名称: DNA polymerase sliding clamp, consensus FEN-1 peptide 著者 Chapados, B.R, Hosfield, D.J, Han, S, Qiu, J, Yelent, B, Shen, B, Tainer, J.A. 登録日 2003-12-18 公開日 2004-01-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair Cell(Cambridge,Mass.), 116, 2004
9F6D	Human DNA polymerase epsilon bound to DNA and PCNA (open conformation) 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... 著者 Roske, J.J, Yeeles, J.T.P. 登録日 2024-05-01 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
9B8S	Human polymerase epsilon bound to PCNA and DNA in the nucleotide exchange state 分子名称: DNA (5'-D(P*AP*AP*AP*GP*TP*GP*AP*AP*AP*AP*AP*TP*CP*TP*AP*AP*AP*GP*CP*AP*TP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*AP*TP*GP*CP*TP*TP*TP*AP*GP*AP*TP*TP*TP*TP*TP*C)-3'), DNA polymerase epsilon catalytic subunit A, ... 著者 Wang, F, He, Q, Li, H. 登録日 2024-03-31 公開日 2024-09-11 最終更新日 2024-10-02 実験手法 ELECTRON MICROSCOPY (5.01 Å) 主引用文献 Structures of the human leading strand Pol epsilon-PCNA holoenzyme. Nat Commun, 15, 2024
9B8T	Human polymerase epsilon bound to PCNA and DNA in the nucleotide bound state 分子名称: DNA polymerase epsilon catalytic subunit, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2024-03-31 公開日 2024-09-11 最終更新日 2024-10-02 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structures of the human leading strand Pol epsilon-PCNA holoenzyme. Nat Commun, 15, 2024
3VKX	Structure of PCNA 分子名称: 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ... 著者 Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N. 登録日 2011-11-26 公開日 2012-03-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication J.Biol.Chem., 287, 2012
9F6F	Human DNA polymerase epsilon bound to DNA and PCNA (closed conformation) 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... 著者 Roske, J.J, Yeeles, J.T.P. 登録日 2024-05-01 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.75 Å) 主引用文献 Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
9F6E	Human DNA polymerase epsilon bound to DNA and PCNA (ajar conformation) 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... 著者 Roske, J.J, Yeeles, J.T.P. 登録日 2024-05-01 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
5AUJ	Pyrococcus furiosus proliferating cell nuclear antigen (PCNA) SeMet derivative 分子名称: DNA polymerase sliding clamp 著者 Watanabe, Y, Oyama, T. 登録日 2015-04-21 公開日 2016-04-27 最終更新日 2020-02-19 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Pyrococcus furiosus proliferating cell nuclear antigen (PCNA) SeMet derivative To Be Published
8PPV	Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches 分子名称: DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
8PPT	Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch 分子名称: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
8PPU	Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing three consecutive mismatches 分子名称: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(C7R)P*(PST)P*(PST)P*(PST))-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
3F1W	Crystal structure of a mutant proliferating cell nuclear antigen that blocks translesion synthesis 分子名称: Proliferating cell nuclear antigen 著者 Freudenthal, B.D, Ramaswamy, S, Washington, M.T. 登録日 2008-10-28 公開日 2008-12-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis. Biochemistry, 47, 2008
7QNZ	human Lig1-DNA-PCNA complex reconstituted in absence of ATP 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ... 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2021-12-23 公開日 2023-01-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.58 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
7QO1	complex of DNA ligase I and FEN1 on PCNA and DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ... 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2021-12-23 公開日 2023-01-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
8Q7I	PCNA from Chaetomium thermophilum in complex with Fen1 peptide 分子名称: Flap endonuclease 1, Proliferating cell nuclear antigen, SODIUM ION 著者 Alphey, M.S, Wolford, C.B, MacNeill, S.A. 登録日 2023-08-16 公開日 2023-12-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA. Front Mol Biosci, 10, 2023
5CFK	Crystal structure of Proliferating Cell Nuclear Antigen from Leishmania donovani at 3.2 A resolution 分子名称: Proliferating cell nuclear antigen,Proliferating cell nuclear antigen 著者 Shukla, P.K, Yadav, S.P, Sharma, P, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-07-08 公開日 2015-10-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of Proliferating Cell Nuclear Antigen from Leishmania donovani at 3.2 A resolution To Be Published
7RPW	Archaeal DNA ligase and heterotrimeric PCNA in complex with adenylated DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-04 公開日 2021-11-17 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.38 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7RPO	Archaeal DNA ligase and heterotrimeric PCNA in complex with non-ligatable DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-03 公開日 2021-11-17 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7RPX	Archaeal DNA ligase and heterotrimeric PCNA in complex with end-joined DNA 分子名称: DNA ligase, DNA polymerase sliding clamp 1, DNA polymerase sliding clamp 2, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-04 公開日 2021-11-17 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
3FDS	Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA polymerase IV, ... 著者 Ling, H. 登録日 2008-11-26 公開日 2009-01-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA Mol.Microbiol., 71, 2009
5DAI	Proliferating cell nuclear antigen homolog 1 bound to FEN-1 peptide 分子名称: C-terminus of FEN-1 protein, DNA polymerase sliding clamp 1, SULFATE ION 著者 Ladner, J.E, Altieri, A.S, Kelman, Z. 登録日 2015-08-20 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp. Nucleic Acids Res., 44, 2016
3V62	Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164 分子名称: ATP-dependent DNA helicase SRS2, N-ETHYLMALEIMIDE, Proliferating cell nuclear antigen, ... 著者 Armstrong, A.A, Mohideen, F, Lima, C.D. 登録日 2011-12-18 公開日 2012-02-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature, 483, 2012
5DA7	monomeric PCNA bound to a small protein inhibitor 分子名称: DNA polymerase sliding clamp 1, Proliferating cell nuclear antigen, SULFATE ION, ... 著者 Ladner, J.E, Altieri, A.S, Kelman, Z. 登録日 2015-08-19 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.802 Å) 主引用文献 A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp. Nucleic Acids Res., 44, 2016
8P9O	PCNA from Chaetomium thermophilum in complex with PolD3 peptide 分子名称: Proliferating cell nuclear antigen, Synthetic peptide corresponding to amino acids 437 to 451 of PolD3 from Chaetomium thermophilum 著者 Alphey, M.S, Wolford, C.B, MacNeill, S.A. 登録日 2023-06-06 公開日 2023-12-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA. Front Mol Biosci, 10, 2023
3WGW	Structure of PCNA bound to a small molecule inhibitor 分子名称: 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION 著者 Hashimoto, H. 登録日 2013-08-12 公開日 2014-02-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289, 2014

<123456789>