3KJQ
 
 | | Caspase 8 with covalent inhibitor | | 分子名称: | (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-8 | | 著者 | Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G. | | 登録日 | 2009-11-03 | | 公開日 | 2010-08-11 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
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3K7E
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2XZT
 | | Caspase-3 in Complex with DARPin-3.4_I78S | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, CASPASE-3, DARPIN-3.4_I78S | | 著者 | Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. | | 登録日 | 2010-11-29 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Caspase-3 in Complex with Darpin-3.4_I78S
To be Published
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2WDP
 | | Crystal Structure of Ligand Free Human Caspase-6 | | 分子名称: | CASPASE-6, PHOSPHATE ION | | 著者 | Baumgartner, R, Briand, C, Meder, G, Morse, R, Renatus, M. | | 登録日 | 2009-03-25 | | 公開日 | 2009-10-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Crystal Structure of Caspase-6, a Selective Effector of Axonal Degeneration.
Biochem.J., 423, 2009
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2XYP
 | | Caspase-3:CAS26049945 | | 分子名称: | CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE | | 著者 | Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. | | 登録日 | 2010-11-18 | | 公開日 | 2011-08-17 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.
Acta Crystallogr.,Sect.F, 67, 2011
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2XYG
 | | Caspase-3:CAS329306 | | 分子名称: | CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide | | 著者 | Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. | | 登録日 | 2010-11-17 | | 公開日 | 2011-08-17 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.
Acta Crystallogr.,Sect.F, 67, 2011
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2XZD
 | | Caspase-3 in Complex with an Inhibitory DARPin-3.4 | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ... | | 著者 | Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. | | 登録日 | 2010-11-24 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
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2QL5
 | | Crystal Structure of caspase-7 with inhibitor AC-DMQD-CHO | | 分子名称: | CITRIC ACID, Caspase-7, inhibitor, ... | | 著者 | Agniswamy, J, Fang, B, Weber, I. | | 登録日 | 2007-07-12 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.
Febs J., 274, 2007
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2QLJ
 | | Crystal Structure of Caspase-7 with Inhibitor AC-WEHD-CHO | | 分子名称: | CITRIC ACID, Caspase-7, Inhibitor AC-WEHD-CHO, ... | | 著者 | Agniswamy, J, Fang, B, Weber, I. | | 登録日 | 2007-07-12 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.
Febs J., 274, 2007
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2QL9
 | | Crystal Structure of Caspase-7 with inhibitor AC-DQMD-CHO | | 分子名称: | CITRIC ACID, Caspase-7, Inhibitor AC-DQMD-CHO, ... | | 著者 | Agniswamy, J, Fang, B, Weber, I. | | 登録日 | 2007-07-12 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.
Febs J., 274, 2007
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2Y0B
 | | Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ... | | 著者 | Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. | | 登録日 | 2010-12-01 | | 公開日 | 2011-12-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
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2Y1L
 | | Caspase-8 in Complex with DARPin-8.4 | | 分子名称: | 1,2-ETHANEDIOL, AC-IETD-CHO, Caspase-8, ... | | 著者 | Barandun, J, Schroeder, T, Mittl, P.R.E, Grutter, M.G. | | 登録日 | 2010-12-08 | | 公開日 | 2011-12-28 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Caspase-8 in Complex with Darpin-8.4
To be Published
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2XYH
 | | Caspase-3:CAS60254719 | | 分子名称: | 5-CHLORO-4-OXOPENTANOIC ACID, CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17 | | 著者 | Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. | | 登録日 | 2010-11-17 | | 公開日 | 2011-08-17 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.
Acta Crystallogr.,Sect.F, 67, 2011
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2QL7
 | | Crystal Structure of Caspase-7 with inhibitor AC-IEPD-CHO | | 分子名称: | CITRIC ACID, Caspase-7, Inhibitor AC-IEPD_CHO, ... | | 著者 | Agniswamy, J, Fang, B, Weber, I. | | 登録日 | 2007-07-12 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.
Febs J., 274, 2007
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2QLF
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2QLB
 | | Crystal Structure of caspase-7 with inhibitor AC-ESMD-CHO | | 分子名称: | CITRIC ACID, Caspase-7, Inhibitor AC-ESMD-CHO, ... | | 著者 | Agniswamy, J, Fang, B, Weber, I. | | 登録日 | 2007-07-12 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.
Febs J., 274, 2007
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2P2C
 | | Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin) | | 分子名称: | Caspase-2 | | 著者 | Roschitzki Voser, H, Briand, C, Capitani, G, Gruetter, M.G. | | 登録日 | 2007-03-07 | | 公開日 | 2007-05-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | | 主引用文献 | Inhibition of Caspase-2 by a Designed Ankyrin Repeat Protein: Specificity, Structure, and Inhibition Mechanism.
Structure, 15, 2007
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4LSZ
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3NS7
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4M9R
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3NR2
 | | Crystal structure of Caspase-6 zymogen | | 分子名称: | Caspase-6 | | 著者 | Su, X.-D, Wang, X.-J, Liu, X, Mi, W, Wang, K.-T. | | 登録日 | 2010-06-30 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
Embo Rep., 11, 2010
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4N7M
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3OD5
 | | Crystal structure of active caspase-6 bound with Ac-VEID-CHO | | 分子名称: | CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO | | 著者 | Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. | | 登録日 | 2010-08-11 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
Embo Rep., 11, 2010
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3P45
 | | Crystal structure of apo-caspase-6 at physiological pH | | 分子名称: | caspase-6 | | 著者 | Mueller, I, Lamers, M.B.A.C, Ritchie, A.J, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. | | 登録日 | 2010-10-06 | | 公開日 | 2011-06-15 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Crystal structures of active and inhibitor-bound human Casp6
To be Published
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7WR0
 | | P32 of caspase-4 C258A mutant | | 分子名称: | Caspase-4 | | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | | 登録日 | 2022-01-26 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.
Nat.Struct.Mol.Biol., 30, 2023
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