2P2C
Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)
Summary for 2P2C
Entry DOI | 10.2210/pdb2p2c/pdb |
Related | 1MJO 1PYO |
Descriptor | Caspase-2, ... (4 entities in total) |
Functional Keywords | apoptosis, caspase, caspase-2, inhibition, protein design, protein libraries, designed ankyrin repeat proteins, ribosome display, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 18 |
Total formula weight | 297019.76 |
Authors | Roschitzki Voser, H.,Briand, C.,Capitani, G.,Gruetter, M.G. (deposition date: 2007-03-07, release date: 2007-05-22, Last modification date: 2023-08-30) |
Primary citation | Schweizer, A.,Roschitzki-Voser, H.,Amstutz, P.,Briand, C.,Gulotti-Georgieva, M.,Prenosil, E.,Binz, H.K.,Capitani, G.,Baici, A.,Pluckthun, A.,Grutter, M.G. Inhibition of Caspase-2 by a Designed Ankyrin Repeat Protein: Specificity, Structure, and Inhibition Mechanism. Structure, 15:625-636, 2007 Cited by PubMed: 17502107DOI: 10.1016/j.str.2007.03.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.24 Å) |
Structure validation
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