2P2C
Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J, M... (A, C, E, G, I...) | Caspase-2 | polymer | 169 | 19006.6 | 6 | UniProt (P42575) Pfam (PF00656) | Homo sapiens (human) | |
| 2 | B, E, H, K, N... (B, D, F, H, J...) | Caspase-2 | polymer | 106 | 12052.2 | 6 | UniProt (P42575) Pfam (PF00656) | Homo sapiens (human) | |
| 3 | C, F, I, L, O... (P, Q, R, S, T...) | Caspase-2 | polymer | 169 | 18444.6 | 6 | Homo sapiens (human) | ||
| 4 | AA, BA, CA, DA, EA... (G, H, S, I, L...) | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 2 - 168 (UniProt: P42575)
B, D, F, H, J, L: 201 - 305 (UniProt: P42575)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | cloning artifact |
| Ala 1 | - | cloning artifact |
| Leu 7 | Val 172 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met 200 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 297019.8 | |
| All* | Total formula weight | 297019.8 |
