PDB: 117 件ウェブページステータス検索Chemie searchBIRD

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6W89	Structure of DNMT3A (R882H) in complex with CGA DNA 分子名称: CGA DNA (25-MER), CITRIC ACID, DNA (cytosine-5)-methyltransferase 3-like, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-20 公開日 2020-04-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.499 Å) 主引用文献 Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W8B	Structure of DNMT3A in complex with CGA DNA 分子名称: CGA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-20 公開日 2020-04-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
4YOC	Crystal Structure of human DNMT1 and USP7/HAUSP complex 分子名称: DNA (cytosine-5)-methyltransferase 1, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION 著者 Cheng, J, Yang, H, Fang, J, Gong, R, Wang, P, Li, Z, Xu, Y. 登録日 2015-03-11 公開日 2015-05-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.916 Å) 主引用文献 Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun, 6, 2015
4WXX	The crystal structure of human DNMT1(351-1600) 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Zhang, Z.M, Song, J. 登録日 2014-11-14 公開日 2015-07-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.622 Å) 主引用文献 Crystal Structure of Human DNA Methyltransferase 1. J.Mol.Biol., 427, 2015
5WY1	Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) 分子名称: DNA (cytosine-5)-methyltransferase 1, ZINC ION 著者 Kanada, K, Takeshita, K, Suetake, I, Tajima, S, Nakagawa, A. 登録日 2017-01-10 公開日 2017-05-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1 J. Biochem., 162, 2017
5GUT	The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Chen, S.J, Ye, F. 登録日 2016-08-31 公開日 2017-09-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
5GUV	The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D 分子名称: DNA (cytosine-5)-methyltransferase 1, ZINC ION 著者 Ye, F, Chen, S.J. 登録日 2016-08-31 公開日 2017-08-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.078 Å) 主引用文献 Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
4U7P	Crystal structure of DNMT3A-DNMT3L complex 分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y. 登録日 2014-07-31 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.821 Å) 主引用文献 Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
4U7T	Crystal structure of DNMT3A-DNMT3L in complex with histone H3 分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Guo, X, Wang, L, Yin, X, Li, J, Xiao, J, He, S, Wang, J, Xu, Y. 登録日 2014-07-31 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
7UBU	Crystal structure of ZMET2 in complex with hemimethylated CAG DNA and a histone H3Kc9me2 peptide 分子名称: 5MC SSDNA, C49 SSDNA, DNA (cytosine-5)-methyltransferase 1, ... 著者 Fang, J, Song, J. 登録日 2022-03-15 公開日 2022-06-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Mechanistic basis for maintenance of CHG DNA methylation in plants. Nat Commun, 13, 2022
4DA4	Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA 分子名称: CITRIC ACID, DNA (cytosine-5)-methyltransferase 1, DNA_LOWER_STRAND, ... 著者 Song, J, Patel, D.J. 登録日 2012-01-12 公開日 2012-02-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation. Science, 335, 2012
6X9I	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9K	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9J	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
7R78	cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH 分子名称: DNA (5'-D(*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*CP*AP*GP*(5CM)P*GP*CP*AP*T)-3'), DNA repair protein Rad8, ... 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7R76	Cryo-EM structure of DNMT5 in apo state 分子名称: DNA repair protein Rad8, ZINC ION 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7R77	Cryo-EM structure of DNMT5 binary complex with hemimethylated DNA 分子名称: DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ZINC ION 著者 Wang, J, Patel, D.J. 登録日 2021-06-24 公開日 2022-02-23 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
7XI9	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form) 分子名称: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Structural basis for activation of DNMT1. Nat Commun, 13, 2022
7XIB	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form) 分子名称: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (2.23 Å) 主引用文献 Structural basis for activation of DNMT1. Nat Commun, 13, 2022
8EIK	Cryo-EM structure of human DNMT3B homo-hexamer 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EII	Cryo-EM structure of human DNMT3B homo-tetramer (form II) 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EIH	Cryo-EM structure of human DNMT3B homo-tetramer (form I) 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EIJ	Cryo-EM structure of human DNMT3B homo-trimer 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
4FSX	crystal structure of Se-substituted Zea mays ZMET2 in complex with SAH 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE 著者 Du, J, Patel, D.J. 登録日 2012-06-27 公開日 2012-10-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
4FT4	crystal structure of Zea mays ZMET2 in complex H3(1-32)K9me2 peptide and SAH 分子名称: DNA (cytosine-5)-methyltransferase 1, H3(1-32)K9me2 peptide, S-ADENOSYL-L-HOMOCYSTEINE 著者 Du, J, Patel, D.J. 登録日 2012-06-27 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012

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