PDB: 121 件ウェブページステータス検索Chemie searchBIRD

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6U8V	Crystal structure of DNMT3B-DNMT3L in complex with CpGpT DNA 分子名称: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... 著者 Gao, L, Zhang, Z.M, Song, J. 登録日 2019-09-06 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U8W	Crystal structure of DNMT3B(K777A)-DNMT3L in complex with CpGpT DNA 分子名称: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... 著者 Gao, L, Zhang, Z.M, Song, J. 登録日 2019-09-06 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.94891548 Å) 主引用文献 Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6W8B	Structure of DNMT3A in complex with CGA DNA 分子名称: CGA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-20 公開日 2020-04-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
6W89	Structure of DNMT3A (R882H) in complex with CGA DNA 分子名称: CGA DNA (25-MER), CITRIC ACID, DNA (cytosine-5)-methyltransferase 3-like, ... 著者 Anteneh, H, Song, J. 登録日 2020-03-20 公開日 2020-04-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.499 Å) 主引用文献 Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation. Nat Commun, 11, 2020
4U7P	Crystal structure of DNMT3A-DNMT3L complex 分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y. 登録日 2014-07-31 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.821 Å) 主引用文献 Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
4U7T	Crystal structure of DNMT3A-DNMT3L in complex with histone H3 分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Guo, X, Wang, L, Yin, X, Li, J, Xiao, J, He, S, Wang, J, Xu, Y. 登録日 2014-07-31 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
7T02	Cryo-EM structure of DNMT5 pseudo-ternary complex solved by incubation with hemimethylated DNA and SAM 分子名称: DNA (5'-D(*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ... 著者 Wang, J, Patel, D.J. 登録日 2021-11-29 公開日 2022-02-23 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82, 2022
5WY1	Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) 分子名称: DNA (cytosine-5)-methyltransferase 1, ZINC ION 著者 Kanada, K, Takeshita, K, Suetake, I, Tajima, S, Nakagawa, A. 登録日 2017-01-10 公開日 2017-05-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1 J. Biochem., 162, 2017
4WXX	The crystal structure of human DNMT1(351-1600) 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Zhang, Z.M, Song, J. 登録日 2014-11-14 公開日 2015-07-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.622 Å) 主引用文献 Crystal Structure of Human DNA Methyltransferase 1. J.Mol.Biol., 427, 2015
5GUT	The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Chen, S.J, Ye, F. 登録日 2016-08-31 公開日 2017-09-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
4DA4	Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA 分子名称: CITRIC ACID, DNA (cytosine-5)-methyltransferase 1, DNA_LOWER_STRAND, ... 著者 Song, J, Patel, D.J. 登録日 2012-01-12 公開日 2012-02-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation. Science, 335, 2012
7UBU	Crystal structure of ZMET2 in complex with hemimethylated CAG DNA and a histone H3Kc9me2 peptide 分子名称: 5MC SSDNA, C49 SSDNA, DNA (cytosine-5)-methyltransferase 1, ... 著者 Fang, J, Song, J. 登録日 2022-03-15 公開日 2022-06-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Mechanistic basis for maintenance of CHG DNA methylation in plants. Nat Commun, 13, 2022
5GUV	The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D 分子名称: DNA (cytosine-5)-methyltransferase 1, ZINC ION 著者 Ye, F, Chen, S.J. 登録日 2016-08-31 公開日 2017-08-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.078 Å) 主引用文献 Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
4YOC	Crystal Structure of human DNMT1 and USP7/HAUSP complex 分子名称: DNA (cytosine-5)-methyltransferase 1, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION 著者 Cheng, J, Yang, H, Fang, J, Gong, R, Wang, P, Li, Z, Xu, Y. 登録日 2015-03-11 公開日 2015-05-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.916 Å) 主引用文献 Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun, 6, 2015
3SWR	Structure of human DNMT1 (601-1600) in complex with Sinefungin 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (cytosine-5)-methyltransferase 1, ... 著者 Hashimoto, H, Cheng, X. 登録日 2011-07-14 公開日 2011-08-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structure of human DNMT1 (residues 600-1600) in complex with Sinefungin To be Published
7XI9	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-ordered form) 分子名称: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Structural basis for activation of DNMT1. Nat Commun, 13, 2022
7XIB	Cryo-EM structure of human DNMT1 (aa:351-1616) in complex with ubiquitinated H3 and hemimethylated DNA analog (CXXC-disordered form) 分子名称: DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*TP*CP*(C55)P*GP*TP*AP*AP*GP*T)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Onoda, H, Kikuchi, A, Kori, S, Yoshimi, S, Yamagata, A, Arita, K. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.23 Å) 主引用文献 Structural basis for activation of DNMT1. Nat Commun, 13, 2022
3PT6	Crystal structure of mouse DNMT1(650-1602) in complex with DNA 分子名称: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Song, J, Patel, D.J. 登録日 2010-12-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PTA	Crystal structure of human DNMT1(646-1600) in complex with DNA 分子名称: DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (cytosine-5)-methyltransferase 1, ... 著者 Song, J, Patel, D.J. 登録日 2010-12-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
3PT9	Crystal structure of mouse DNMT1(731-1602) in the free state 分子名称: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Song, J, Patel, D.J. 登録日 2010-12-02 公開日 2010-12-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science, 331, 2011
4FT4	crystal structure of Zea mays ZMET2 in complex H3(1-32)K9me2 peptide and SAH 分子名称: DNA (cytosine-5)-methyltransferase 1, H3(1-32)K9me2 peptide, S-ADENOSYL-L-HOMOCYSTEINE 著者 Du, J, Patel, D.J. 登録日 2012-06-27 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants. Cell(Cambridge,Mass.), 151, 2012
9BAQ	CryoEM structure of DIM2-HP1-H3K9me3-DNA complex 分子名称: DNA (5'-D(*AP*CP*TP*AP*CP*T)-R(P*(PYO))-D(P*CP*TP*CP*CP*TP*CP*CP*TP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*TP*AP*GP*T)-3'), DNA (cytosine-5-)-methyltransferase, ... 著者 Song, J, Shao, Z. 登録日 2024-04-04 公開日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 CryoEM structure of DIM2-HP1-H3K9me3-DNA complex To Be Published
9BAZ	CryoEM structure of DIM2-HP1 complex 分子名称: DNA (cytosine-5-)-methyltransferase, Heterochromatin protein one, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Song, J, Shao, Z. 登録日 2024-04-05 公開日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 CryoEM structure of DIM2-HP1 complex To Be Published
8EIK	Cryo-EM structure of human DNMT3B homo-hexamer 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023
8EIJ	Cryo-EM structure of human DNMT3B homo-trimer 分子名称: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Lu, J.W, Song, J.K. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Structural basis for the allosteric regulation and dynamic assembly of DNMT3B. Nucleic Acids Res., 51, 2023

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