3I8P
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7Q5S
| Protein community member fatty acid synthase complex from C. thermophilum | 分子名称: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, 3-oxoacyl-[acyl-carrier-protein] reductase | 著者 | Chojnowski, G, Skalidis, I, Kyrilis, F.L, Tueting, C, Hamdi, F, Kastritis, P.L. | 登録日 | 2021-11-04 | 公開日 | 2022-02-02 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4.47 Å) | 主引用文献 | Cryo-EM and artificial intelligence visualize endogenous protein community members. Structure, 30, 2022
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2IWZ
| Human mitochondrial beta-ketoacyl ACP synthase complexed with hexanoic acid | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, AMMONIUM ION, HEXANOIC ACID | 著者 | Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A. | 登録日 | 2006-07-05 | 公開日 | 2007-02-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase. Protein Sci., 16, 2007
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6U5T
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2IX4
| Arabidopsis thaliana mitochondrial beta-ketoacyl ACP synthase hexanoic acid complex | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, HEXANOIC ACID, POTASSIUM ION | 著者 | Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A. | 登録日 | 2006-07-06 | 公開日 | 2007-02-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase. Protein Sci., 16, 2007
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6U5U
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6U5V
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6U5W
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7S6B
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7S6C
| CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure | 分子名称: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 4'-PHOSPHOPANTETHEINE, 6-deoxyerythronolide-B synthase EryA2, ... | 著者 | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
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7S6D
| CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure | 分子名称: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, ... | 著者 | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | 登録日 | 2021-09-13 | 公開日 | 2021-11-03 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
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2AQ7
| Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli | 分子名称: | (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | 著者 | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | 登録日 | 2005-08-17 | 公開日 | 2006-01-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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2GQD
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7S2X
| Structure of SalC, a gamma-lactam-beta-lactone bicyclase for salinosporamide biosynthesis | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, POTASSIUM ION, SalC | 著者 | Chen, P.Y.-T, Trivella, D.B.B, Bauman, K.D, Moore, B.S. | 登録日 | 2021-09-04 | 公開日 | 2022-04-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nat.Chem.Biol., 18, 2022
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2HG4
| Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS. | 分子名称: | 6-Deoxyerythronolide B Synthase, ACETATE ION, CHLORIDE ION, ... | 著者 | Tang, Y, Kim, C.Y, Mathews, I.I, Cane, D.E, Khosla, C. | 登録日 | 2006-06-26 | 公開日 | 2006-07-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | The 2.7-A crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2AQB
| Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli | 分子名称: | (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | 著者 | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | 登録日 | 2005-08-17 | 公開日 | 2006-01-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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3HO2
| Structure of E.coli FabF(C163A) in complex with Platencin | 分子名称: | 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 著者 | Soisson, S.M, Parthasarathy, G. | 登録日 | 2009-06-01 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg.Med.Chem.Lett., 19, 2009
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3HMJ
| Saccharomyces cerevisiae FAS type I | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, FLAVIN MONONUCLEOTIDE, ... | 著者 | Johansson, P, Mulinacci, B, Koestler, C, Vollrath, R, Oesterhelt, D, Grininger, M. | 登録日 | 2009-05-29 | 公開日 | 2009-09-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase Structure, 17, 2009
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3LRF
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3KZU
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2ALM
| Crystal structure analysis of a mutant beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae | 分子名称: | 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION | 著者 | Zhang, Y.M, Hurlbert, J, White, S.W, Rock, C.O. | 登録日 | 2005-08-07 | 公開日 | 2005-08-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae. J.Biol.Chem., 281, 2006
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2BUH
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2BZ4
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4OPE
| Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS7 | 分子名称: | NITRATE ION, NRPS/PKS | 著者 | Osipiuk, J, Mack, J, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-02-05 | 公開日 | 2014-02-19 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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2BYW
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