7S2X

Structure of SalC, a gamma-lactam-beta-lactone bicyclase for salinosporamide biosynthesis

Summary for 7S2X

Entry DOI	10.2210/pdb7s2x/pdb
Descriptor	SalC, POTASSIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	salinosporamide, marizomib, bicyclase, cyclase, lactam, lactone, ketosynthase, transferase, biosynthetic protein
Biological source	Salinispora tropica
Total number of polymer chains	4
Total formula weight	259921.12
Authors	Chen, P.Y.-T.,Trivella, D.B.B.,Bauman, K.D.,Moore, B.S. (deposition date: 2021-09-04, release date: 2022-04-06, Last modification date: 2023-10-18)
Primary citation	Bauman, K.D.,Shende, V.V.,Chen, P.Y.,Trivella, D.B.B.,Gulder, T.A.M.,Vellalath, S.,Romo, D.,Moore, B.S. Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nat.Chem.Biol., 18:538-546, 2022 Cited by PubMed: 35314816 DOI: 10.1038/s41589-022-00993-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation