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7Z7D
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BU of 7z7d by Molmil
Tubulin-Todalam-Vinblastine-complex
分子名称: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2022-03-15
公開日2022-04-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Angew.Chem.Int.Ed.Engl., 61, 2022
7Z6S
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BU of 7z6s by Molmil
MATCAP bound to a human 14 protofilament microtubule
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Bak, J, Perrakis, A.
登録日2022-03-14
公開日2022-05-11
最終更新日2022-06-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Posttranslational modification of microtubules by the MATCAP detyrosinase.
Science, 376, 2022
7Z2P
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BU of 7z2p by Molmil
Tubulin-nocodazole complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O.
登録日2022-02-28
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
7Z2N
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BU of 7z2n by Molmil
Tubulin-18-complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Muehlethaler, T, Prota, A.E, Cavalli, A, Steinmetz, M.O.
登録日2022-02-28
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents.
Eur.J.Med.Chem., 241, 2022
7Z2C
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BU of 7z2c by Molmil
P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer
分子名称: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ...
著者Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
登録日2022-02-26
公開日2022-10-19
最終更新日2022-11-30
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7Z2B
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BU of 7z2b by Molmil
P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer
分子名称: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ...
著者Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
登録日2022-02-26
公開日2022-11-16
最終更新日2022-11-30
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7Z2A
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BU of 7z2a by Molmil
P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer
分子名称: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ...
著者Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
登録日2022-02-26
公開日2022-10-19
最終更新日2022-11-30
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7Z02
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BU of 7z02 by Molmil
Z-SBTub2M photoswitch bound to tubulin-DARPin D1 complex
分子名称: 6-methyl-2-[2-(3,4,5-trimethoxyphenyl)ethyl]-1,3-benzothiazole, Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ...
著者Wranik, M, Weinert, T, Standfuss, J, Steinmetz, M.
登録日2022-02-21
公開日2022-03-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.
J.Am.Chem.Soc., 144, 2022
7Z01
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BU of 7z01 by Molmil
Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex
分子名称: 2-methoxy-5-[2-(5,6,7-trimethoxy-1,3-benzothiazol-2-yl)ethyl]phenol, CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J, Steinmetz, M.
登録日2022-02-21
公開日2022-03-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.
J.Am.Chem.Soc., 144, 2022
7YZ6
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BU of 7yz6 by Molmil
Molecular snapshots of drug release from tubulin: Dark (steady state)
分子名称: Azo-Combretastatin A4 (cis), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YZ5
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BU of 7yz5 by Molmil
Molecular snapshots of drug release from tubulin: 100 milliseconds (steady state)
分子名称: CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YZ3
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BU of 7yz3 by Molmil
Molecular snapshots of drug release from tubulin: Apo state
分子名称: CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YZ2
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BU of 7yz2 by Molmil
Molecular snapshots of drug release from tubulin: 10 milliseconds after photoactivation.
分子名称: Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YZ1
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BU of 7yz1 by Molmil
Molecular snapshots of drug release from tubulin: 1 millisecond after photoactivation.
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YZ0
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BU of 7yz0 by Molmil
Molecular snapshots of drug release from tubulin: 100 microseconds after photoactivation.
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YYZ
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BU of 7yyz by Molmil
Molecular snapshots of drug release from tubulin: 10 microseconds after photoactivation.
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YYY
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BU of 7yyy by Molmil
Molecular snapshots of drug release from tubulin: 1 microsecond after photoactivation
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YYX
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BU of 7yyx by Molmil
Molecular snapshots of drug release from tubulin: 100 nanoseconds after photoactivation.
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YYW
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BU of 7yyw by Molmil
Molecular snapshots of drug release from tubulin: 10 nanoseconds after photoactivation.
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YYV
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BU of 7yyv by Molmil
Molecular snapshots of drug release from tubulin: 1 nanosecond after photoactivation.
分子名称: Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YYQ
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BU of 7yyq by Molmil
Molecular snapshots of drug release from tubulin: Dark state
分子名称: Azo-Combretastatin A4 (cis), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
著者Wranik, M, Weinert, T, Standfuss, J.
登録日2022-02-18
公開日2023-02-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
7YSZ
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BU of 7ysz by Molmil
Spiroplasma melliferum FtsZ bound to GDP
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE
著者Chakraborty, J, Pananghat, G.
登録日2022-08-13
公開日2023-08-16
実験手法X-RAY DIFFRACTION (2.3000412 Å)
主引用文献Structural basis of kinetic polarity of FtsZ from a cell wall less bacterium Spiroplasma
To Be Published
7YSR
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BU of 7ysr by Molmil
GTPgammaS MT decorated with kinesin
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7YSQ
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BU of 7ysq by Molmil
GTPgammaS Tube decorated with kinesin
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7YSP
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BU of 7ysp by Molmil
Tubulin heterodimer structure of GDP-2 state in solution
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha-1B chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023

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件を2024-06-12に公開中

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