7YZ5

Molecular snapshots of drug release from tubulin: 100 milliseconds (steady state)

Summary for 7YZ5

Entry DOI	10.2210/pdb7yz5/pdb
Descriptor	Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ... (8 entities in total)
Functional Keywords	time-resolved serial crystallography, tubulin dynamics, azobenzene dynamics, cell cycle
Biological source	synthetic construct More
Total number of polymer chains	3
Total formula weight	119303.53
Authors	Wranik, M.,Weinert, T.,Standfuss, J. (deposition date: 2022-02-18, release date: 2023-02-22, Last modification date: 2024-02-07)
Primary citation	Wranik, M.,Weinert, T.,Slavov, C.,Masini, T.,Furrer, A.,Gaillard, N.,Gioia, D.,Ferrarotti, M.,James, D.,Glover, H.,Carrillo, M.,Kekilli, D.,Stipp, R.,Skopintsev, P.,Brunle, S.,Muhlethaler, T.,Beale, J.,Gashi, D.,Nass, K.,Ozerov, D.,Johnson, P.J.M.,Cirelli, C.,Bacellar, C.,Braun, M.,Wang, M.,Dworkowski, F.,Milne, C.,Cavalli, A.,Wachtveitl, J.,Steinmetz, M.O.,Standfuss, J. Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography. Nat Commun, 14:903-903, 2023 Cited by PubMed: 36807348 DOI: 10.1038/s41467-023-36481-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation