PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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6DFM	Crystal structure of human GRP78 in complex with 8-aminoadenosine 分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-05-15 公開日 2019-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Crystal structure of human GRP78 in complex with 8-aminoadenosine To be Published
6GFA	Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 105 kDa, MAGNESIUM ION 著者 Gonzalez, D, Gotthard, G, Gozzi, G.J, Seigneuric, R, Neiers, F, Briand, L, Garrido, C. 登録日 2018-04-29 公開日 2019-05-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy. Cell Death Differ., 27, 2020
6NHK	Mortalin nucleotide binding domain in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Page, R.C, Moseng, M.A, Nix, J.C. 登録日 2018-12-23 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
6CZ1	Crystal structure of ATPase domain of Human GRP78 bound to Ver155008 分子名称: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION 著者 Antoshchenko, T, Chen, Y, Hughes, S, Park, H. 登録日 2018-04-07 公開日 2019-04-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystallographic selection of adenosine analogs that fit the mold of the active site of human GRP78 and beyond To be Published
6H9U	Crystal structure of the BiP NBD and MANF SAP complex 分子名称: D-MALATE, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor, ... 著者 Yan, Y, Ron, D. 登録日 2018-08-06 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
6HAB	Crystal structure of BiP V461F (apo) 分子名称: DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP 著者 Yan, Y, Ron, D. 登録日 2018-08-07 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
6HA7	Crystal structure of the BiP NBD and MANF complex 分子名称: 1,2-ETHANEDIOL, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor 著者 Yan, Y, Ron, D. 登録日 2018-08-07 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
6FHK	Structure of a modified protein containing a genetically encoded phosphoserine 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ... 著者 Mukherjee, M, Bayliss, R. 登録日 2018-01-14 公開日 2018-10-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.657 Å) 主引用文献 Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release. Sci Signal, 11, 2018
6G3S	Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Second structure of two TEW-HSP70 structures deposited. 分子名称: 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... 著者 Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. 登録日 2018-03-26 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PLoS ONE, 13, 2018
6G3R	Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Structure one of two TEW-HSP70 structures deposited. 分子名称: 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... 著者 Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. 登録日 2018-03-26 公開日 2018-10-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PLoS ONE, 13, 2018
5XI9	Solution structure for human HSP70 substrate binding domain 分子名称: Heat shock 70 kDa protein 1A 著者 Hoshikawa, M, Tochio, N, Tate, S. 登録日 2017-04-26 公開日 2018-05-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5XIR	Solution structure for human HSP70 substrate binding domain L542Y mutant 分子名称: Heat shock 70 kDa protein 1A 著者 Hoshikawa, M, Tochio, N, Tate, S. 登録日 2017-04-27 公開日 2018-05-16 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5OBU	Mycoplasma genitalium DnaK deletion mutant lacking SBDalpha in complex with AMPPNP. 分子名称: Chaperone protein DnaK, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Adell, M, Calisto, B, Fita, I, Martinelli, L. 登録日 2017-06-29 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
5OBW	Mycoplasma genitalium DnaK-NBD in complex with ATP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Adell, M, Calisto, B, Fita, I, Martinelli, L. 登録日 2017-06-29 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
5OBY	Mycoplasma genitalium DnaK-NBD in complex with AMP-PNP 分子名称: Chaperone protein DnaK, GLYCEROL, MAGNESIUM ION, ... 著者 Adell, M, Calisto, B, Fita, I, Martinelli, L. 登録日 2017-06-29 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
5OBV	Mycoplasma genitalium DnaK deletion mutant lacking SBDalpha in complex with ADP and Pi. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein DnaK, PHOSPHATE ION 著者 Adell, M, Calisto, B, Fita, I, Martinelli, L. 登録日 2017-06-29 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
5OBX	Mycoplasma genitalium DnaK-NBD 分子名称: Chaperone protein DnaK, GLYCEROL, SULFATE ION, ... 著者 Adell, M, Calisto, B, Fita, I, Martinelli, L. 登録日 2017-06-29 公開日 2018-05-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone. Protein Sci., 27, 2018
5OOW	Crystal structure of lobe II from the nucleotide binding domain of DnaK in complex with AMPPCP 分子名称: Chaperone protein DnaK, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER 著者 Jakob, R.P, Bauer, D, Meinhold, S, Stigler, J, Merkel, U, Maier, T, Rief, M, Zoldak, G. 登録日 2017-08-09 公開日 2018-04-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NRO	Structure of full-length DnaK with bound J-domain 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaJ, Chaperone protein DnaK, ... 著者 Kopp, J, Kityk, R, Mayer, M.P. 登録日 2017-04-25 公開日 2018-01-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones. Mol. Cell, 69, 2018
6B1N	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
6B1I	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
6B1M	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: GLYCEROL, Heat shock protein family A (Hsp70) member 8, MAGNESIUM ION, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
6ASY	BiP-ATP2 分子名称: 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... 著者 Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. 登録日 2017-08-26 公開日 2017-12-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
6EOF	Crystal structure of AMPylated GRP78 in ADP state 分子名称: 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Yan, Y, Preissler, S, Read, R.J, Ron, D. 登録日 2017-10-09 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017
5O4P	Crystal structure of AMPylated GRP78 分子名称: 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, SULFATE ION 著者 Yan, Y, Chen, R, Ron, D, Read, R. 登録日 2017-05-30 公開日 2017-11-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017

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