PDB: 2832 件ウェブページステータス検索Chemie searchBIRD

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8VZL	DNA Ligase 1 captured with pre-step 3 ligation at the rG:C nicksite 分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... 著者 KanalElamparithi, B, Gulkis, M, Caglayan, M. 登録日 2024-02-11 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA. J.Biol.Chem., 300, 2024
7KR3	Human DNA Ligase 1(E346A/E592A) Bound to a bulged DNA substrate 分子名称: ACETATE ION, ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*CP*C)-3'), ... 著者 Tumbale, P.P, Williams, R.S. 登録日 2020-11-18 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.778 Å) 主引用文献 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication. Nat Commun, 12, 2021
7KR4	Human DNA Ligase 1(E346A/E592A) Bound to a nicked DNA substrate control duplex 分子名称: ACETATE ION, ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*C)-3'), ... 著者 Tumbale, P.P, Williams, R.S. 登録日 2020-11-18 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication. Nat Commun, 12, 2021
6P0C	Human DNA Ligase 1 Bound to an Adenylated, hydroxyl terminated DNA nick in EDTA 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... 著者 Schellenberg, M.J, Tumbale, P.S, Riccio, A.A, Williams, R.S. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6P09	Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6P0B	Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6P0A	Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 2 mM Mg2+ 分子名称: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6P0D	Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-05-16 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6Q1V	Human DNA Ligase 1 (E592R) Bound to an Adenylated, hydroxyl terminated DNA nick 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ADENOSINE MONOPHOSPHATE, ... 著者 Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. 登録日 2019-08-06 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
6DRT	Crystal structure of the processivity clamp GP45 complexed with recognition peptide of ligase from bacteriophage T4 分子名称: 1,2-ETHANEDIOL, DNA polymerase clamp, GP45 recognition loop 著者 Shi, K, Aihara, H. 登録日 2018-06-13 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.117 Å) 主引用文献 T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction. Nucleic Acids Res., 46, 2018
6IMK	The crystal structure of AsfvLIG:CG complex 分子名称: DNA (5'-D(*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*CP*CP*GP*CP*AP*TP*CP*CP*CP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*GP*GP*GP*AP*TP*GP*CP*GP*G)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*CP*TP*GP*G)-3'), ... 著者 Chen, Y.Q, Gan, J.H. 登録日 2018-10-23 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues. Nat Commun, 10, 2019
6IML	The crystal structure of AsfvLIG:CT1 complex 分子名称: DNA (5'-D(*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*CP*CP*GP*CP*AP*TP*CP*CP*CP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*GP*GP*GP*AP*TP*GP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*CP*TP*GP*G)-3'), ... 著者 Chen, Y.Q, Gan, J.H. 登録日 2018-10-23 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues. Nat Commun, 10, 2019
3BAC	Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase 分子名称: DNA ligase, N-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-7-yl)-2-methylpropyl]-4-phenoxybenzamide, PHOSPHATE ION 著者 Pinko, C. 登録日 2007-11-07 公開日 2008-11-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase To be Published
2OD8	Structure of a peptide derived from Cdc9 bound to PCNA 分子名称: DNA ligase I, mitochondrial precursor, Proliferating cell nuclear antigen 著者 Chapados, B.R, Tainer, J.A. 登録日 2006-12-21 公開日 2007-05-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res., 35, 2007
2E2W	Solution structure of the first BRCT domain of human DNA ligase IV 分子名称: DNA ligase 4 著者 Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-11-17 公開日 2006-12-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the first BRCT domain of human DNA ligase IV TO BE PUBLISHED
2FAR	Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with dATP and Manganese 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MANGANESE (II) ION, SULFATE ION, ... 著者 Zhu, H, Nandakumar, J, Aniukwu, J, Wang, L.K, Glickman, M.S, Lima, C.D, Shuman, S. 登録日 2005-12-07 公開日 2006-05-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Proc.Natl.Acad.Sci.USA, 103, 2006
2FAQ	Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with ATP and Manganese 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, SULFATE ION, ... 著者 Zhu, H, Nandakumar, J, Aniukwu, J, Wang, L.K, Glickman, M.S, Lima, C.D, Shuman, S. 登録日 2005-12-07 公開日 2006-05-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Proc.Natl.Acad.Sci.USA, 103, 2006
2FAO	Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain 分子名称: SULFATE ION, probable ATP-dependent DNA ligase 著者 Zhu, H, Nandakumar, J, Aniukwu, J, Wang, L.K, Glickman, M.S, Lima, C.D, Shuman, S. 登録日 2005-12-07 公開日 2006-05-23 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Proc.Natl.Acad.Sci.USA, 103, 2006
4UCU	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-hydroxyquinoline-2-carboxylic acid, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
4UCT	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-amino-6-methyl-5-(propan-2-yloxy)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
4UCV	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-methoxy-2,3-dimethylquinoxalin-5-ol, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
4UCO	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
4UCR	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-hydroxy-2-methylquinoline-6-carboxamide, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
4UCS	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
6RAS	Pmar-Lig_Pre. 分子名称: ADENOSINE MONOPHOSPHATE, ATP-dependent DNA ligase, DNA, ... 著者 Leiros, H.K.S, Williamson, A. 登録日 2019-04-07 公開日 2019-07-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation. Nucleic Acids Res., 47, 2019

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