4UCT

Fragment bound to H.influenza NAD dependent DNA ligase

Summary for 4UCT

• Entry DOI: 10.2210/pdb4uct/pdb
• Related: 4UCO 4UCR 4UCS 4UCU 4UCV
• Descriptor: DNA LIGASE, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-amino-6-methyl-5-(propan-2-yloxy)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium, ... (4 entities in total)
• Functional Keywords: ligase
• Biological source: HAEMOPHILUS INFLUENZAE
• Total number of polymer chains: 1
• Total formula weight: 36977.88

Authors

Hale, M.,Brassington, C.,Carcanague, D.,Embrey, K.,Eyermann, C.J.,Giacobbe, R.A.,Gingipali, L.,Gowravaram, M.,Harang, J.,Howard, T.,Ioannidis, G.,Jahic, H.,Kutschke, A.,Laganas, V.A.,Loch, J.,Miller, M.D.,Murphy-Benenato, K.E.,Oguto, H.,Otterbein, L.,Patel, S.J.,Shapiro, A.B.,Boriack-Sjodin, P.A. (deposition date: 2014-12-04, release date: 2015-10-14, Last modification date: 2017-06-28)

• Primary citation: Hale, M.,Brassington, C.,Carcanague, D.,Embrey, K.,Eyermann, C.J.,Giacobbe, R.A.,Gingipali, L.,Gowravaram, M.,Harang, J.,Howard, T.,Ioannidis, G.,Jahic, H.,Kutschke, A.,Laganas, V.A.,Loch, J.,Miller, M.D.,Murphy-Benenato, K.E.,Oguto, H.,Otterbein, L.,Patel, S.J.,Shapiro, A.B.,Boriack-Sjodin, P.A.; From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors; Tetrahedron Lett., 56:3108-, 2015; DOI: 10.1016/J.TETLET.2014.12.067

Experimental method

X-RAY DIFFRACTION (2.1 Å)