8VZL

DNA Ligase 1 captured with pre-step 3 ligation at the rG:C nicksite

Summary for 8VZL

• Entry DOI: 10.2210/pdb8vzl/pdb
• Descriptor: DNA ligase 1, DNA/RNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-R(P*G)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... (6 entities in total)
• Functional Keywords: lig1, dna ligase 1, ligase, ligase-dna complex, ligase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 85680.05

Authors

KanalElamparithi, B.,Gulkis, M.,Caglayan, M. (deposition date: 2024-02-11, release date: 2024-05-22)

• Primary citation: Balu, K.E.,Gulkis, M.,Almohdar, D.,Caglayan, M.; Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA.; J.Biol.Chem., 300:107216-107216, 2024; PubMed: 38522520; DOI: 10.1016/j.jbc.2024.107216

Experimental method

X-RAY DIFFRACTION (2.41 Å)