PDB: 2013 件ウェブページステータス検索Chemie searchBIRD

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5U0B	Structure of full-length Zika virus NS5 分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Zhao, B, Du, F. 登録日 2016-11-23 公開日 2017-03-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and function of the Zika virus full-length NS5 protein. Nat Commun, 8, 2017
5U0C	Structure of Zika virus NS5 RNA polymerase domain 分子名称: NS5 RNA polymerase domain, ZINC ION 著者 Zhao, B, Du, F. 登録日 2016-11-23 公開日 2017-03-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and function of the Zika virus full-length NS5 protein. Nat Commun, 8, 2017
5U04	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase 分子名称: PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp 著者 Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G. 登録日 2016-11-22 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. Nat Commun, 8, 2017
5TWN	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, NS5B RNA- DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-11-14 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. Medchemcomm, 8, 2017
5TWM	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide 分子名称: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, NS5B RNA-dependent RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-11-14 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. Medchemcomm, 8, 2017
5TSN	Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex 分子名称: MANGANESE (II) ION, Norwalk virus polymerase, RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3') 著者 Shaik, M.M, Ng, K.K. 登録日 2016-10-30 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins, 85, 2017
5TRJ	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-{[2-(carboxymethoxy)benzene-1-carbonyl]amino}-3-[(4-chlorophenyl)methoxy]benzoic acid 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-{[2-(carboxymethoxy)benzene-1-carbonyl]amino}-3-[(4-chlorophenyl)methoxy]benzoic acid, RNA-DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
5TRH	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid, NS5B RNA-DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
5TRI	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid, NS5B RNA-DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
5TRK	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH N-{3-[(benzenecarbonyl)amino]-4-[(4-chlorophenyl)methoxy]benzene-1-carbonyl}glycine 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, Genome polyprotein, N-{3-[(benzenecarbonyl)amino]-4-[(4-chlorophenyl)methoxy]benzene-1-carbonyl}glycine, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
5M64	RNA Polymerase I elongation complex with A49 tandem winged helix domain 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Tafur, L, Sadian, Y, Hoffmann, N.A, Jakobi, A.J, Wetzel, R, Hagen, W.J.H, Sachse, C, Muller, C.W. 登録日 2016-10-24 公開日 2016-12-21 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Molecular Structures of Transcribing RNA Polymerase I. Mol. Cell, 64, 2016
5M5W	RNA Polymerase I open complex 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Tafur, L, Sadian, Y, Hoffmann, N.A, Jakobi, A.J, Wetzel, R, Hagen, W.J.H, Sachse, C, Muller, C.W. 登録日 2016-10-23 公開日 2016-12-07 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Molecular Structures of Transcribing RNA Polymerase I. Mol. Cell, 64, 2016
5M5Y	RNA Polymerase I elongation complex 2 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Tafur, L, Sadian, Y, Hoffmann, N.A, Jakobi, A.J, Wetzel, R, Hagen, W.J.H, Sachse, C, Muller, C.W. 登録日 2016-10-23 公開日 2016-12-21 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Molecular Structures of Transcribing RNA Polymerase I. Mol. Cell, 64, 2016
5M5X	RNA Polymerase I elongation complex 1 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Tafur, L, Sadian, Y, Hoffmann, N.A, Jakobi, A.J, Wetzel, R, Hagen, W.J.H, Sachse, C, Muller, C.W. 登録日 2016-10-23 公開日 2016-12-21 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Molecular Structures of Transcribing RNA Polymerase I. Mol. Cell, 64, 2016
5M3M	Free monomeric RNA polymerase I at 4.0A resolution 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S. 登録日 2016-10-15 公開日 2016-11-23 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of RNA polymerase I transcribing ribosomal DNA genes. Nature, 540, 2016
5M3J	Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD 分子名称: DNA-directed RNA polymerase subunit, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Pflug, A, Cusack, S. 登録日 2016-10-14 公開日 2016-12-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis of an essential interaction between influenza polymerase and Pol II CTD. Nature, 541, 2017
5M3H	Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Pflug, A, Cusack, S. 登録日 2016-10-14 公開日 2016-12-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of an essential interaction between influenza polymerase and Pol II CTD. Nature, 541, 2017
5M3F	Yeast RNA polymerase I elongation complex at 3.8A 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Neyer, S, Kunz, M, Geiss, C, Hantsche, M, Hodirnau, V.-V, Seybert, A, Engel, C, Scheffer, M.P, Cramer, P, Frangakis, A.S. 登録日 2016-10-14 公開日 2016-11-23 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of RNA polymerase I transcribing ribosomal DNA genes. Nature, 540, 2016
5M2X	Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033) 分子名称: NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N. 登録日 2016-10-13 公開日 2018-06-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4.991 Å) 主引用文献 Supramolecular arrangement of the full-length Zika virus NS5. Plos Pathog., 15, 2019
5M2Z	Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033) 分子名称: NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N. 登録日 2016-10-13 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (4.8 Å) 主引用文献 Supramolecular arrangement of the full-length Zika virus NS5. Plos Pathog., 15, 2019
5TMH	Structure of Zika virus NS5 分子名称: GLYCEROL, Polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Wang, B, Tan, X, Song, J. 登録日 2016-10-12 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.278 Å) 主引用文献 The structure of Zika virus NS5 reveals a conserved domain conformation. Nat Commun, 8, 2017
5H0S	EM Structure of VP1A and VP1B 分子名称: VP1 著者 Li, X, Zhou, N, Xu, B, Chen, W, Zhu, B, Wang, X, Wang, J, Liu, H, Cheng, L. 登録日 2016-10-06 公開日 2017-01-25 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV J. Mol. Biol., 429, 2017
5H0R	RNA dependent RNA polymerase ,vp4,dsRNA 分子名称: RNA (42-MER), RNA-dependent RNA polymerase, VP4 protein 著者 Li, X, Zhou, N, Chen, W, Zhu, B, Wang, X, Xu, B, Wang, J, Liu, H, Cheng, L. 登録日 2016-10-06 公開日 2017-01-25 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV J. Mol. Biol., 429, 2017
5TFO	CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE with a deletion V76-L86 in NS2b 分子名称: NS2B-NS3 Protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 Protease CHIMERA 著者 Aleshin, A.E, Bankston, L, Liddington, R.C. 登録日 2016-09-26 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design. To Be Published
5TFN	CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE in super-open conformation 分子名称: NS2B-NS3 Protease CHIMERA,Genome polyprotein 著者 Aleshin, A.E, Bankston, L, Liddington, R.C. 登録日 2016-09-26 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design. To Be Published

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