1JG3
 
 | | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA substrate | | 分子名称: | ADENOSINE, CHLORIDE ION, SODIUM ION, ... | | 著者 | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | | 登録日 | 2001-06-22 | | 公開日 | 2001-11-16 | | 最終更新日 | 2011-07-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
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4HXW
 | | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | | 分子名称: | (3R)-1-[5-chloro-6-ethyl-2-(pyrido[2,3-b]pyrazin-7-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrrolidin-3-amine, DNA gyrase subunit B, TERTIARY-BUTYL ALCOHOL | | 著者 | Bensen, D.C, Trzoss, M, Tari, L.W. | | 登録日 | 2012-11-12 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
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1I1E
 | | CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN | | 分子名称: | BOTULINUM NEUROTOXIN TYPE B, DOXORUBICIN, SULFATE ION, ... | | 著者 | Eswaramoorthy, S, Kumaran, D, Swaminathan, S. | | 登録日 | 2001-02-01 | | 公開日 | 2001-11-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B.
Acta Crystallogr.,Sect.D, 57, 2001
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4I74
 | | Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 and allosterically inhibited by a Ni2+ ion | | 分子名称: | (2R,3R,4S)-2-(hydroxymethyl)-1-[(4-hydroxythieno[3,2-d]pyrimidin-7-yl)methyl]pyrrolidine-3,4-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | 著者 | Giannese, F, Degano, M. | | 登録日 | 2012-11-30 | | 公開日 | 2013-08-07 | | 最終更新日 | 2013-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
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3U2W
 | | Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and glucose or a glucal species | | 分子名称: | 1,5-anhydro-D-arabino-hex-1-enitol, GLYCEROL, Glycogenin-1, ... | | 著者 | Chaikuad, A, Froese, D.S, Krysztofinska, E, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Oppermann, U, Yue, W.W, Structural Genomics Consortium (SGC) | | 登録日 | 2011-10-04 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3C2V
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1ZF8
 | | GGT Duplex A-DNA | | 分子名称: | 5'-D(*CP*CP*AP*CP*CP*GP*GP*TP*GP*G)-3', CALCIUM ION | | 著者 | Hays, F.A, Teegarden, A.T, Jones, Z.J.R, Harms, M, Raup, D, Watson, J, Cavaliere, E, Ho, P.S. | | 登録日 | 2005-04-20 | | 公開日 | 2005-05-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | How sequence defines structure: a crystallographic map of DNA structure and conformation.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1R43
 | | Crystal structure of beta-alanine synthase from Saccharomyces kluyveri (selenomethionine substituted protein) | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-AMINO ISOBUTYRATE, ... | | 著者 | Lundgren, S, Gojkovic, Z, Piskur, J, Dobritzsch, D. | | 登録日 | 2003-10-03 | | 公開日 | 2003-11-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Yeast beta-Alanine Synthase Shares a Structural Scaffold and Origin with Dizinc-dependent Exopeptidases
J.Biol.Chem., 278
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3TUZ
 | | Inward facing conformations of the MetNI methionine ABC transporter: CY5 SeMet soak crystal form | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, D-methionine transport system permease protein metI, Methionine import ATP-binding protein MetN, ... | | 著者 | Johnson, E, Nguyen, P, Rees, D.C. | | 登録日 | 2011-09-19 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Inward facing conformations of the MetNI methionine ABC transporter: Implications for the mechanism of transinhibition.
Protein Sci., 21, 2012
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2NX3
 | | Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase | | 分子名称: | (2R,4R,5R,6R,7R)-2,4,5,6,7-PENTAHYDROXY-2,8-BIS(PHOSPHONOOXY)OCTANOIC ACID, 2-dehydro-3-deoxyphosphooctonate aldolase, ARABINOSE-5-PHOSPHATE, ... | | 著者 | Kona, F, Xu, X, Martin, P, Kuzmic, P, Gatti, D.L. | | 登録日 | 2006-11-16 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
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3TUI
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1JG2
 | | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine | | 分子名称: | ADENOSINE, SODIUM ION, protein-L-isoaspartate O-methyltransferase | | 著者 | Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O. | | 登録日 | 2001-06-22 | | 公開日 | 2001-11-16 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
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1V7M
 | | Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab | | 分子名称: | Monoclonal TN1 Fab Heavy Chain, Monoclonal TN1 Fab Light Chain, Thrombopoietin | | 著者 | Feese, M.D, Tamada, T, Kato, Y, Maeda, Y, Hirose, M, Matsukura, Y, Shigematsu, H, Kato, T, Miyazaki, H, Kuroki, R. | | 登録日 | 2003-12-18 | | 公開日 | 2004-03-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004
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1RK0
 | | Mhc Class I H-2Kb Heavy Chain Complexed With beta-2 Microglobulin and Herpes Simplex Virus Glycoprotein B peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Glycoprotein B, ... | | 著者 | Miley, M.J, Messaoudi, I, Nikolich-Zugich, J, Fremont, D.H. | | 登録日 | 2003-11-20 | | 公開日 | 2004-12-14 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
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6M5P
 | | A class C beta-lactamase | | 分子名称: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase | | 著者 | Bae, D.W, Jung, Y.E, Cha, S.S. | | 登録日 | 2020-03-11 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Novel inhibition mechanism of carbapenems on the ACC-1 class C beta-lactamase.
Arch.Biochem.Biophys., 693, 2020
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1DFV
 | | CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN MONOMER | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN NEUTROPHIL GELATINASE, ... | | 著者 | Goetz, D.H, Willie, S.T, Armen, R.S, Bratt, T, Borregaard, N, Strong, R.K. | | 登録日 | 1999-11-22 | | 公開日 | 2000-03-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin
Biochemistry, 39, 2000
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4I72
 | | Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with Immucillin A | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, CALCIUM ION, ... | | 著者 | Giannese, F, Degano, M. | | 登録日 | 2012-11-30 | | 公開日 | 2013-08-07 | | 最終更新日 | 2013-12-18 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
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1W05
 | | Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Alanine-Fe Complex | | 分子名称: | DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-ALANINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ... | | 著者 | Long, A.J, Clifton, I.J, Rutledge, P.J. | | 登録日 | 2004-06-01 | | 公開日 | 2005-05-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine
Biochemistry, 44, 2005
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3ELC
 | | Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand | | 分子名称: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one, GERANYL DIPHOSPHATE, ... | | 著者 | Hunter, W.N, Ramsden, N.L, Ulaganathan, V. | | 登録日 | 2008-09-22 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009
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1P53
 | | The Crystal Structure of ICAM-1 D3-D5 fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Intercellular adhesion molecule-1 | | 著者 | Yang, Y, Jun, C.D, Liu, J.H, Zhang, R, Jochimiak, A, Springer, T.A, Wang, J.H. | | 登録日 | 2003-04-24 | | 公開日 | 2004-05-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | | 主引用文献 | Structural basis for dimerization of ICAM-1 on the cell surface.
Mol.Cell, 14, 2004
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231D
 | | STRUCTURE OF A DNA-PORPHYRIN COMPLEX | | 分子名称: | CU(II)MESO(4-N-TETRAMETHYLPYRIDYL)PORPHYRIN, DNA (5'-D(*CP*GP*AP*TP*CP*G)-3'), SODIUM ION | | 著者 | Lipscomb, L.A, Zhou, F.X, Presnell, S.R, Woo, R.J, Peek, M.E, Plaskon, R.R, Williams, L.D. | | 登録日 | 1995-08-25 | | 公開日 | 1996-03-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of DNA-porphyrin complex.
Biochemistry, 35, 1996
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2NT1
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1V51
 | | The functional role of the binuclear metal center in D-aminoacylase. One-metal activation and second-metal attenuation | | 分子名称: | ACETATE ION, D-aminoacylase, ZINC ION | | 著者 | Lai, W.L, Chou, L.Y, Ting, C.Y, Tsai, Y.C, Liaw, S.H. | | 登録日 | 2003-11-20 | | 公開日 | 2004-04-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The functional role of the binuclear metal center in D-aminoacylase: one-metal activation and second-metal attenuation.
J.Biol.Chem., 279, 2004
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2A3Z
 | | Ternary complex of the WH2 domain of WASP with Actin-DNAse I | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Chereau, D, Kerff, F, Dominguez, R. | | 登録日 | 2005-06-27 | | 公開日 | 2005-11-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.078 Å) | | 主引用文献 | Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Proc.Natl.Acad.Sci.Usa, 102, 2005
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3NMQ
 | | Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor | | 分子名称: | 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol, Heat shock protein HSP 90-beta | | 著者 | Arndt, J.W, Yun, T.J, Harning, E.K, Giza, K, Rabah, D, Li, P, Luchetti, D, Shi, J, Manning, A, Kehry, M.R. | | 登録日 | 2010-06-22 | | 公開日 | 2010-12-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
J.Immunol., 186, 2011
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