PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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5YVG	Crystal structure of Karyopherin beta2 in complex with FUS(full length) 分子名称: RNA-binding protein FUS, Transportin-1 著者 Yoshizawa, T, Fung, H.Y.J, Chook, Y.M. 登録日 2017-11-25 公開日 2018-05-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.05 Å) 主引用文献 Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173, 2018
6WWX	Crystal structure of truncated bacteriophage hyaluronan lyase HylP in complex with unsaturated hyaluronan tetra-saccharides 分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hyaluronoglucosaminidase, NICKEL (II) ION 著者 Deivanayagam, C, Schormann, N. 登録日 2020-05-09 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of Streptococcal Bacteriophage Hyaluronidase: Presence of a Prokaryotic Collagen and Elucidation of Catalytic Mechanism To Be Published
6WXA	Crystal structure of truncated Streptococcal bacteriophage hyaluronidase complexed with unsaturated hyaluronan hexa-saccharides 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Deivanayagam, C, Schormann, N. 登録日 2020-05-10 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Streptococcal Bacteriophage Hyaluronidase: Presence of a Prokaryotic Collagen and Elucidation of Catalytic Mechanism To Be Published
6X3M	Crystal structure of full-length Streptococcal bacteriophage hyaluronidase in complex with unsaturated hyaluronan octa-saccharides 分子名称: 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hyaluronoglucosaminidase 著者 Deivanayagam, C, Schormann, N. 登録日 2020-05-21 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.581 Å) 主引用文献 Crystal Structure of Streptococcal Bacteriophage Hyaluronidase: Presence of a Prokaryotic Collagen and Elucidation of Catalytic Mechanism To Be Published
3CP9	Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor 分子名称: 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one, Vascular endothelial growth factor receptor 2 著者 Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H. 登録日 2008-03-31 公開日 2008-06-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. J.Med.Chem., 51, 2008
5YVH	Crystal structure of Karyopherin beta2 in complex with FUS(371-526) 分子名称: RNA-binding protein FUS, Transportin-1 著者 Yoshizawa, T, Fung, H.Y.J, Chook, Y.M. 登録日 2017-11-25 公開日 2018-05-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173, 2018
3CTT	Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CASUARINE, GLYCEROL, ... 著者 Sim, L, Rose, D.R. 登録日 2008-04-14 公開日 2009-02-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families Chemistry, 15, 2009
7UAD	Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 分子名称: 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 著者 Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. 登録日 2022-03-12 公開日 2023-07-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.044 Å) 主引用文献 The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
3CPB	Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor 分子名称: N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide, Vascular endothelial growth factor receptor 2 著者 Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H. 登録日 2008-03-31 公開日 2008-06-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit. J.Med.Chem., 51, 2008
3Q7Y	Crystal structure of K15R/E18D/Y22W/H41G/F44W/E51D/E53P/K57R/E60D/Y64W/H82G/F85W/E90D/E94P/K98R/E101D/Y108W/H129G/F132W/E137D Symfoil-4P: de novo designed beta-trefoil architecture with symmetric primary structure 分子名称: De novo designed beta-trefoil architecture with symmetric primary structure 著者 Blaber, M, Lee, J. 登録日 2011-01-05 公開日 2012-01-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein. Proc.Natl.Acad.Sci.USA, 110, 2013
7UT1	Higher-order assembly of multiple MMTV strand transfer complex intasomes 分子名称: Integrase, ZINC ION, tDNA strand, ... 著者 Jozwik, I, Lyumkis, D. 登録日 2022-04-26 公開日 2022-08-24 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 B-to-A transition in target DNA during retroviral integration. Nucleic Acids Res., 50, 2022
5YVI	Crystal structure of Karyopherin beta2 in complex with FUS(456-526) 分子名称: RNA-binding protein FUS, Transportin-1 著者 Yoshizawa, T, Fung, H.Y.J, Chook, Y.M. 登録日 2017-11-25 公開日 2018-05-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173, 2018
3DKW	Crystal Structure of DNR from Pseudomonas aeruginosa. 分子名称: DNR protein 著者 Giardina, G. 登録日 2008-06-26 公開日 2009-05-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild-type DNR. Proteins, 2009
6XW2	Crystal structure of the bright genetically encoded calcium indicator NCaMP7 based on mNeonGreen fluorescent protein 分子名称: CALCIUM ION, Genetically encoded calcium indicator NCaMP7 based on mNeonGreen fluorescent protein, SULFATE ION 著者 Boyko, K.M, Nikolaeva, A.Y, Korzhenevskiy, D.A, Lazarenko, V.A, Subach, O.M, Subach, F.V. 登録日 2020-01-22 公開日 2020-01-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein. Int J Mol Sci, 21, 2020
7UXK	Structure of CDK2 in complex with FP24322, a Helicon Polypeptide 分子名称: 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, FP24322, ... 著者 Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. 登録日 2022-05-05 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7UXI	Structure of CDK2 in complex with FP19711, a Helicon Polypeptide 分子名称: AMINO GROUP, Cyclin-dependent kinase 2, FP19711, ... 著者 Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. 登録日 2022-05-05 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7UXM	Structure of PPIA in complex with FP29092, a Helicon Polypeptide 分子名称: 1,2-ETHANEDIOL, AMINO GROUP, FP29092, ... 著者 Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. 登録日 2022-05-05 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7UXJ	Structure of PPIA in complex with FP29102, a Helicon Polypeptide 分子名称: AMINO GROUP, FP29102, N,N'-(1,4-phenylene)diacetamide, ... 著者 Li, K, Agarwal, S, Tokareva, O, Thomson, T, Wahl, S, Verdine, G, McGee, J. 登録日 2022-05-05 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7UXN	Structure of PPIA in complex with FP29103, a Helicon Polypeptide 分子名称: FP29103, N,N'-(1,4-phenylene)diacetamide, Peptidyl-prolyl cis-trans isomerase A 著者 Li, K, Agarwal, S, Tokareva, O, Thomson, T, Tattersfield, H, Wahl, S, Verdine, G, McGee, J. 登録日 2022-05-05 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA, 119, 2022
7TZ7	PI3K alpha in complex with an inhibitor 分子名称: (4S,5R)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one, Isoform 3 of Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Knapp, M.S, Tang, J. 登録日 2022-02-15 公開日 2022-05-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor. J.Med.Chem., 65, 2022
2V8X	Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives 分子名称: 7-BENZYL GUANINE MONOPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 著者 Brown, C.J, Mcnae, I, Fischer, P.M, Walkinshaw, M.D. 登録日 2007-08-16 公開日 2007-08-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives. J.Mol.Biol., 372, 2007
6L2F	Crystal structure of a cupin protein (tm1459, H54AH58A mutant) in copper (Cu) substituted form 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, COPPER (II) ION, ... 著者 Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. 登録日 2019-10-03 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes. Angew.Chem.Int.Ed.Engl., 59, 2020
3Q7W	Crystal structure of Symfoil-4P/PV1: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 1 分子名称: SULFATE ION, de novo designed beta-trefoil architecture with symmetric primary structure 著者 Blaber, M, Lee, J. 登録日 2011-01-05 公開日 2012-01-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein. Proc.Natl.Acad.Sci.USA, 110, 2013
7UO6	NMR structure of Pheromone-binding protein 2 in Ostrinia furnacalis 分子名称: Pheromone binding protein 2 著者 Ayyappan, S, Mohanty, S. 登録日 2022-04-12 公開日 2023-02-15 実験手法 SOLUTION NMR 主引用文献 Ostrinia furnacalis PBP2 solution NMR structure: Insight into ligand binding and release mechanisms. Protein Sci., 31, 2022
6L2E	Crystal structure of a cupin protein (tm1459, H52A mutant) in copper (Cu) substituted form 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COPPER (II) ION, Cupin_2 domain-containing protein 著者 Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. 登録日 2019-10-03 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.201 Å) 主引用文献 Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes. Angew.Chem.Int.Ed.Engl., 59, 2020

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