6YPS
 
 | | Crystal structure of the cAMP-dependent protein kinase A in complex with 4-hydroxybenzamidine | | 分子名称: | 4-oxidanylbenzenecarboximidamide, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha | | 著者 | Oebbeke, M, Siefker, C, Heine, A, Klebe, G. | | 登録日 | 2020-04-16 | | 公開日 | 2020-12-09 | | 最終更新日 | 2020-12-30 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts.
Angew.Chem.Int.Ed.Engl., 60, 2021
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2H2R
 | | Crystal structure of the human CD23 Lectin domain, apo form | | 分子名称: | Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IgE receptor) (Fc-epsilon-RII)(Immunoglobulin E-binding factor) (CD23 antigen) | | 著者 | Wurzburg, B.A. | | 登録日 | 2006-05-19 | | 公開日 | 2006-06-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Changes in the Lectin Domain of CD23, the Low-Affinity IgE Receptor, upon Calcium Binding.
Structure, 14, 2006
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2LD5
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2LA6
 | | Solution NMR Structure of RRM domain of RNA-binding protein FUS from homo sapiens, Northeast Structural Genomics Consortium Target HR6430A | | 分子名称: | RNA-binding protein FUS | | 著者 | Liu, G, Xiao, R, Janjua, H, Ciccosanti, C, Wang, H, Lee, H, Acton, T.B, Everett, J.K, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2011-03-04 | | 公開日 | 2011-05-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Northeast Structural Genomics Consortium Target HR6430A
To be Published
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2LH1
 | | X-RAY STRUCTURAL INVESTIGATION OF LEGHEMOGLOBIN. VI. STRUCTURE OF ACETATE-FERRILEGHEMOGLOBIN AT A RESOLUTION OF 2.0 ANGSTROMS (RUSSIAN) | | 分子名称: | ACETATE ION, LEGHEMOGLOBIN (ACETO MET), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Vainshtein, B.K, Harutyunyan, E.H, Kuranova, I.P, Borisov, V.V, Sosfenov, N.I, Pavlovsky, A.G, Grebenko, A.I, Konareva, N.V. | | 登録日 | 1982-04-23 | | 公開日 | 1983-01-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-Ray Structural Investigation of Leghemoglobin. Vi. Structure of Acetate-Ferrileghemoglobin at a Resolution of 2.0 Angstroms (Russian)
Kristallografiya, 25, 1980
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2H53
 | | Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26 | | 分子名称: | small heat shock protein Hsp26 | | 著者 | White, H.E, Orlova, E.V, Chen, S, Wang, L, Ignatiou, A, Gowen, B, Stromer, T, Franzmann, T.M, Haslbeck, M, Buchner, J, Saibil, H.R. | | 登録日 | 2006-05-25 | | 公開日 | 2006-08-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (11.5 Å) | | 主引用文献 | Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein hsp26
Structure, 14, 2006
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6Y6H
 | | Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe | | 分子名称: | 1,2-ETHANEDIOL, 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B | | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-02-26 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J.Med.Chem., 63, 2020
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2LH5
 | | X-RAY STRUCTURAL INVESTIGATION OF LEGHEMOGLOBIN. VI. STRUCTURE OF ACETATE-FERRILEGHEMOGLOBIN AT A RESOLUTION OF 2.0 ANGSTROMS (RUSSIAN) | | 分子名称: | FLUORIDE ION, LEGHEMOGLOBIN (FLUORO MET), PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Vainshtein, B.K, Harutyunyan, E.H, Kuranova, I.P, Borisov, V.V, Sosfenov, N.I, Pavlovsky, A.G, Grebenko, A.I, Konareva, N.V. | | 登録日 | 1982-04-23 | | 公開日 | 1983-01-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-Ray Structural Investigation of Leghemoglobin. Vi. Structure of Acetate-Ferrileghemoglobin at a Resolution of 2.0 Angstroms (Russian)
Kristallografiya, 25, 1980
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2H6Y
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2LHB
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2H8I
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2GYZ
 | | Crystal structure of human artemin | | 分子名称: | neurotrophic factor artemin isoform 3 | | 著者 | Wang, X.Q, Garcia, K.C. | | 登録日 | 2006-05-10 | | 公開日 | 2006-06-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
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6Y82
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6Y8H
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2LEC
 | | Solution structure of human SRSF2 (SC35) RRM in complex with 5'-UGGAGU-3' | | 分子名称: | RNA (5'-R(*UP*GP*GP*AP*GP*U)-3'), Serine/arginine-rich splicing factor 2 | | 著者 | Daubner, G.M, Clery, A, Jayne, S, Stevenin, J, Allain, F.H.-T. | | 登録日 | 2011-06-15 | | 公開日 | 2011-11-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well.
Embo J., 31, 2012
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2HB5
 | | Crystal Structure of the Moloney Murine Leukemia Virus RNase H Domain | | 分子名称: | MAGNESIUM ION, Reverse transcriptase/ribonuclease H, SULFATE ION | | 著者 | Lim, D, Gregorio, G.G, Bingman, C.A, Martinez-Hackert, E, Hendrickson, W.A, Goff, S.P. | | 登録日 | 2006-06-13 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-03-22 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Crystal Structure of the Moloney Murine Leukemia Virus RNase H Domain.
J.Virol., 80, 2006
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2LA4
 | | NMR structure of the C-terminal RRM domain of poly(U) binding 1 | | 分子名称: | Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 | | 著者 | Santiveri, C.M, Mirassou, Y, Rico-Lastres, P, Martinez-Lumbreras, S, Perez-Canadillas, J.M. | | 登録日 | 2011-03-01 | | 公開日 | 2011-09-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site
Plos One, 6, 2011
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6Y4W
 | | Crystal structure of p38 in complex with SR69 | | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(cyclohexylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | | 著者 | Chaikuad, A, Roehm, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-02-23 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK.
Eur.J.Med.Chem., 208, 2020
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6YCW
 | | Fragment KCL_K767 in complex with MAP kinase p38-alpha | | 分子名称: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, Mitogen-activated protein kinase 14, ... | | 著者 | De Nicola, G.F, Nichols, C.E. | | 登録日 | 2020-03-19 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
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2HDV
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2LJH
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2H34
 | | Apoenzyme crystal structure of the tuberculosis serine/threonine kinase, PknE | | 分子名称: | BROMIDE ION, SODIUM ION, Serine/threonine-protein kinase pknE | | 著者 | Gay, L.M, Ng, H.L, Alber, T. | | 登録日 | 2006-05-22 | | 公開日 | 2006-07-18 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A Conserved Dimer and Global Conformational Changes in the Structure of apo-PknE Ser/Thr Protein Kinase from Mycobacterium tuberculosis.
J.Mol.Biol., 360, 2006
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2HDX
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2HEE
 | | CONTRIBUTION OF WATER MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY | | 分子名称: | LYSOZYME, SODIUM ION | | 著者 | Takano, K, Funahashi, J, Yamagata, Y, Fujii, S, Yutani, K. | | 登録日 | 1997-09-16 | | 公開日 | 1998-01-14 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Contribution of water molecules in the interior of a protein to the conformational stability.
J.Mol.Biol., 274, 1997
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2LKD
 | | IF2-G2 GDP complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Translation initiation factor IF-2 | | 著者 | Wienk, H, Tishchenko, E, Belardinelli, R, Tomaselli, S, Dongre, R, Spurio, R, Folkers, G.E, Gualerzi, C.O, Boelens, R. | | 登録日 | 2011-10-10 | | 公開日 | 2012-02-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Dynamics of Bacterial Translation Initiation Factor IF2.
J.Biol.Chem., 287, 2012
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