6YPS
Crystal structure of the cAMP-dependent protein kinase A in complex with 4-hydroxybenzamidine
Summary for 6YPS
Entry DOI | 10.2210/pdb6yps/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, DIMETHYL SULFOXIDE, 4-oxidanylbenzenecarboximidamide, ... (4 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41408.03 |
Authors | Oebbeke, M.,Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2020-04-16, release date: 2020-12-09, Last modification date: 2020-12-30) |
Primary citation | Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60:252-258, 2021 Cited by PubMed: 33021032DOI: 10.1002/anie.202011295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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