3AUO
| DNA polymerase X from Thermus thermophilus HB8 ternary complex with 1-nt gapped DNA and ddGTP | 分子名称: | 1-nt gapped DNA, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase beta family (X family), ... | 著者 | Nakane, S, Nakagawa, N, Masui, R, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2011-02-11 | 公開日 | 2012-01-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structural basis of the kinetic mechanism of a gap-filling X-family DNA polymerase that binds Mg(2+)-dNTP before binding to DNA. J.Mol.Biol., 417, 2012
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5EZF
| Racemic crystal structures of Pribnow box consensus promoter sequence (Pbca) | 分子名称: | CALCIUM ION, Complementary strand, Pribnow box template strand | 著者 | Mandal, P.K, Collie, G.W, Kauffmann, B, Srivastava, S.C, Huc, I. | 登録日 | 2015-11-26 | 公開日 | 2016-05-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure elucidation of the Pribnow box consensus promoter sequence by racemic DNA crystallography. Nucleic Acids Res., 44, 2016
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1Z6J
| Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor | 分子名称: | 5-[AMINO(IMINO)METHYL]-2-[({[6-[3-AMINO-5-({[(1R)-1-METHYLPROPYL]AMINO}CARBONYL)PHENYL]-3-(ISOPROPYLAMINO)-2-OXOPYRAZIN-1(2H)-YL]ACETYL}AMINO)METHYL]-N-PYRIDIN-4-YLBENZAMIDE, CALCIUM ION, Coagulation factor VII, ... | 著者 | Schweitzer, B.A, Neumann, W.L, Rahman, H.K, Kusturin, C.L, Sample, K.R, Poda, G.I, Kurumbail, R.G, Stevens, A.M, Stegeman, R.A, Stallings, W.C. | 登録日 | 2005-03-22 | 公開日 | 2005-05-03 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg.Med.Chem.Lett., 15, 2005
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1TQB
| Ovine recombinant PrP(114-234), VRQ variant in complex with the Fab of the VRQ14 antibody | 分子名称: | VRQ14 Fab Heavy chain, VRQ14 Fab light chain, prion protein | 著者 | Eghiaian, F, Grosclaude, J, Debey, P, Doublet, B, Treguer, E, Rezaei, H, Knossow, M. | 登録日 | 2004-06-17 | 公開日 | 2004-07-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants Proc.Natl.Acad.Sci.USA, 101, 2004
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2X41
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1NAR
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5J93
| Five minutes iron loaded Rana Catesbeiana H' ferritin variant E57A/E136A/D140A | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. | 登録日 | 2016-04-08 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity. Chemistry, 22, 2016
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3RB6
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1PJX
| 0.85 ANGSTROM STRUCTURE OF SQUID GANGLION DFPASE | 分子名称: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE, ... | 著者 | Koepke, J, Rueterjans, H, Luecke, C, Fritzsch, G. | 登録日 | 2003-06-04 | 公開日 | 2004-06-08 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (0.85 Å) | 主引用文献 | Statistical analysis of crystallographic data obtained from squid ganglion DFPase at 0.85 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
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1KUL
| GLUCOAMYLASE, GRANULAR STARCH-BINDING DOMAIN, NMR, 5 STRUCTURES | 分子名称: | GLUCOAMYLASE | 著者 | Sorimachi, K, Jacks, A.J, Le Gal-Coeffet, M.-F, Williamson, G, Archer, D.B, Williamson, M.P. | 登録日 | 1996-01-12 | 公開日 | 1996-07-11 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the granular starch binding domain of glucoamylase from Aspergillus niger by nuclear magnetic resonance spectroscopy. J.Mol.Biol., 259, 1996
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1KUM
| GLUCOAMYLASE, GRANULAR STARCH-BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | GLUCOAMYLASE | 著者 | Sorimachi, K, Jacks, A.J, Le Gal-Coeffet, M.-F, Williamson, G, Archer, D.B, Williamson, M.P. | 登録日 | 1996-01-12 | 公開日 | 1996-07-11 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the granular starch binding domain of glucoamylase from Aspergillus niger by nuclear magnetic resonance spectroscopy. J.Mol.Biol., 259, 1996
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2X42
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3BCJ
| Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A | 分子名称: | (2S,4R)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CITRIC ACID, ... | 著者 | Zhao, H.T, El-Kabbani, O. | 登録日 | 2007-11-13 | 公開日 | 2008-04-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (0.78 Å) | 主引用文献 | Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism J.Med.Chem., 51, 2008
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4KHN
| Crystal structure of the ternary complex of the D714A mutant of RB69 DNA polymerase | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ... | 著者 | Guja, K.E, Jacewicz, A, Trzemecka, A, Plochocka, D, Yakubovskaya, E, Bebenek, A, Garcia-Diaz, M. | 登録日 | 2013-04-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site. Plos One, 8, 2013
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1P0C
| Crystal Structure of the NADP(H)-Dependent Vertebrate Alcohol Dehydrogenase (ADH8) | 分子名称: | GLYCEROL, NADP-dependent ALCOHOL DEHYDROGENASE, PHOSPHATE ION, ... | 著者 | Rosell, A, Valencia, E, Pares, X, Fita, I, Farres, J, Ochoa, W.F. | 登録日 | 2003-04-10 | 公開日 | 2003-04-22 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of the Vertebrate NADP(H)-dependent Alcohol Dehydrogenase (ADH8) J.Mol.Biol., 330, 2003
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2X40
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1TQC
| Ovine recombinant PrP(114-234), ARR variant in complex with the VRQ14 Fab fragment (IgG2a) | 分子名称: | VRQ14 Fab Heavy chain, VRQ14 Fab light chain, prion protein | 著者 | Eghiaian, F, Grosclaude, J, Lesceu, S, Debey, P, Doublet, B, Treguer, E, Rezaei, H, Knossow, M. | 登録日 | 2004-06-17 | 公開日 | 2004-07-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants Proc.Natl.Acad.Sci.USA, 101, 2004
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2JZ3
| SOCS box elonginBC ternary complex | 分子名称: | Suppressor of cytokine signaling 3, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 | 著者 | Babon, J.J, Sabo, J, Soetopo, A, Yao, S, Bailey, M.F, Zhang, J, Nicola, N.A, Norton, R.S. | 登録日 | 2007-12-27 | 公開日 | 2008-09-23 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase J.Mol.Biol., 381, 2008
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1GGG
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1PPT
| X-RAY ANALYSIS (1.4-ANGSTROMS RESOLUTION) OF AVIAN PANCREATIC POLYPEPTIDE. SMALL GLOBULAR PROTEIN HORMONE | 分子名称: | AVIAN PANCREATIC POLYPEPTIDE, ZINC ION | 著者 | Blundell, T.L, Pitts, J.E, Tickle, I.J, Wood, S.P. | 登録日 | 1981-01-16 | 公開日 | 1981-02-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone. Proc.Natl.Acad.Sci.Usa, 78, 1981
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6N0Q
| BRAF in complex with N-(4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)phenyl)-3-(trifluoromethyl)benzamide. | 分子名称: | N-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide, Serine/threonine-protein kinase B-raf | 著者 | Mamo, M, Appleton, B.A. | 登録日 | 2018-11-07 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Design and Discovery ofN-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. J.Med.Chem., 63, 2020
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8F0R
| Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-4-({(1S,2S,4S)-2-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]cyclohexyl}amino)-2-fluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide, ... | 著者 | Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C. | 登録日 | 2022-11-03 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife, 12, 2023
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6N16
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1WLE
| Crystal Structure of mammalian mitochondrial seryl-tRNA synthetase complexed with seryl-adenylate | 分子名称: | SERYL ADENYLATE, Seryl-tRNA synthetase | 著者 | Chimnaronk, S, Jeppesen, M.G, Suzuki, T, Nyborg, J, Watanabe, K. | 登録日 | 2004-06-25 | 公開日 | 2005-09-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria Embo J., 24, 2005
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6MPX
| Twelve chloride ions induce formation and stabilize the NC1 hexamer of collagen IV assembled from transition state trimers | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Bauer, R, Boudko, S.P, Hudson, B.G. | 登録日 | 2018-10-09 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes. J.Biol.Chem., 294, 2019
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