PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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5LV5	Crystal structure of mouse PRMT6 in complex with inhibitor LH1458 分子名称: 2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]-[(3~{S})-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]azanium, Protein arginine N-methyltransferase 6 著者 Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. 登録日 2016-09-12 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
1DD9	STRUCTURE OF THE DNAG CATALYTIC CORE 分子名称: DNA PRIMASE, STRONTIUM ION 著者 Keck, J.L, Roche, D.D, Lynch, A.S, Berger, J.M. 登録日 1999-11-09 公開日 2000-04-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of the RNA polymerase domain of E. coli primase. Science, 287, 2000
2ZKG	Crystal structure of unliganded SRA domain of mouse Np95 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1 著者 Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. 登録日 2008-03-19 公開日 2008-09-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
1DDE	STRUCTURE OF THE DNAG CATALYTIC CORE 分子名称: DNA PRIMASE, YTTRIUM ION 著者 Keck, J.L, Roche, D.D, Lynch, A.S, Berger, J.M. 登録日 1999-11-09 公開日 2000-04-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the RNA polymerase domain of E. coli primase. Science, 287, 2000
5XFR	Ternary complex of MTF2, DNA and histone 分子名称: DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), Metal-response element-binding transcription factor 2, Peptide from Histone H3.1, ... 著者 Wang, Z, Li, H. 登録日 2017-04-11 公開日 2017-09-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Polycomb-like proteins link the PRC2 complex to CpG islands Nature, 549, 2017
7PLA	Cryo-EM structure of ShCas12k in complex with a sgRNA and a dsDNA target 分子名称: DNA non-target strand, DNA target strand, ShCas12k, ... 著者 Schmitz, M, Jinek, M. 登録日 2021-08-30 公開日 2021-12-01 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Target site selection and remodelling by type V CRISPR-transposon systems. Nature, 599, 2021
6QHD	Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA 分子名称: DNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3 著者 Arbely, E, Belo, Y, Shahar, A, Zarivach, R. 登録日 2019-01-16 公開日 2019-06-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochim Biophys Acta Gen Subj, 1863, 2019
7VOV	The crystal structure of human forkhead box protein in complex with DNA 2 分子名称: DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*T)-3'), Forkhead box protein L2 著者 Choi, Y, Yoon, H.J, Lee, H.H. 登録日 2021-10-15 公開日 2022-08-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
5EYO	The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA 分子名称: DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max 著者 Wang, D, Hashimoto, H, Zhang, X, Cheng, X. 登録日 2015-11-25 公開日 2016-12-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. Nucleic Acids Res., 45, 2017
6J4G	Crystal structure of the AtWRKY33 domain 分子名称: DNA (5'-D(*AP*GP*CP*CP*TP*TP*TP*GP*AP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*TP*GP*GP*TP*CP*AP*AP*AP*GP*GP*C)-3'), Probable WRKY transcription factor 33, ... 著者 Xu, Y.P, Xu, H, Wang, B, Su, X.D. 登録日 2019-01-08 公開日 2020-01-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the N-terminal DNA binding domain of AtWRKY33 To Be Published
8G0Z	Mutant bacteriophage T4 gp41 helicase hexamer bound with single strand DNA and ATPgammaS in the stalled primosome 分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DnaB-like replicative helicase, MAGNESIUM ION, ... 著者 Feng, X, Li, H. 登録日 2023-02-01 公開日 2023-06-14 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
6PQU	Cryo-EM structure of HzTransib/nicked TIR substrate DNA pre-reaction complex (PRC) 分子名称: DNA (5'-D(P*AP*TP*CP*TP*GP*GP*CP*CP*TP*AP*GP*AP*TP*CP*T)-3'), DNA (5'-D(P*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA-mediated transposase, ... 著者 Liu, C, Yang, Y, Schatz, D.G. 登録日 2019-07-10 公開日 2019-10-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of a RAG-like transposase during cut-and-paste transposition. Nature, 575, 2019
7RHZ	Heterodimer of Cre recombinase mutants D33A/A36V/R192A and R72E/L115D/R119D in complex with loxP DNA. 分子名称: DNA (44-MER), Recombinase cre 著者 Stachowski, K, Foster, M.P. 登録日 2021-07-19 公開日 2022-01-19 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.48 Å) 主引用文献 Mechanisms of Cre recombinase synaptic complex assembly and activation illuminated by Cryo-EM. Nucleic Acids Res., 50, 2022
3D2W	Crystal structure of mouse TDP-43 RRM2 domain in complex with DNA 分子名称: DNA (5'-D(*DGP*DTP*DTP*DGP*DAP*DGP*DCP*DGP*DTP*DT)-3'), PHOSPHATE ION, TAR DNA-binding protein 43 著者 Kuo, P.H, Yuan, H.S. 登録日 2008-05-09 公開日 2009-04-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into TDP-43 in nucleic-acid binding and domain interactions Nucleic Acids Res., 37, 2009
6M9M	Streptococcus mutans AlkD2 bound to inosine-5'-monophosphate 分子名称: AlkD2, CHLORIDE ION, INOSINIC ACID 著者 Eichman, B.F, Shi, R. 登録日 2018-08-23 公開日 2018-10-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.401 Å) 主引用文献 Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases. Bioessays, 40, 2018
6PQR	Cryo-EM structure of HzTransib/intact TIR substrate DNA pre-reaction complex (PRC) 分子名称: DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*TP*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*CP*GP*AP*TP*CP*CP*AP*CP*CP*GP*TP*GP*AP*GP*AP*TP*CP*TP*AP*G)-3'), DNA-mediated transposase, ... 著者 Liu, C, Yang, Y, Schatz, D.G. 登録日 2019-07-09 公開日 2019-10-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of a RAG-like transposase during cut-and-paste transposition. Nature, 575, 2019
5FPR	Structure of Bacterial DNA Ligase with small-molecule ligand pyrimidin-2-amine (AT371) in an alternate binding site. 分子名称: DNA LIGASE, PYRIMIDIN-2-AMINE, SULFATE ION 著者 Jhoti, H, Ludlow, R.F, Pathuri, P, Saini, H.K, Tickle, I.J, Tisi, D, Verdonk, M, Williams, P.A. 登録日 2015-12-02 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
6P0G	N-terminal domain of Thermococcus Gammatolerans McrB bound to m5C DNA 分子名称: DNA (5'-D(P*AP*CP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*CP*GP*G)-3'), GTPase subunit of restriction endonuclease 著者 Hosford, C.J, Chappie, J.S. 登録日 2019-05-17 公開日 2019-12-18 最終更新日 2020-01-29 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 The structure of theThermococcus gammatoleransMcrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs. J.Biol.Chem., 295, 2020
6PQY	Cryo-EM structure of HzTransib/TIR DNA transposon end complex (TEC) 分子名称: DNA (5'-D(P*CP*AP*CP*GP*GP*TP*GP*GP*AP*TP*CP*GP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*CP*GP*AP*TP*CP*CP*AP*CP*CP*GP*TP*G)-3'), Putative DNA-mediated transposase 著者 Liu, C, Yang, Y, Schatz, D.G. 登録日 2019-07-10 公開日 2019-10-09 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structures of a RAG-like transposase during cut-and-paste transposition. Nature, 575, 2019
7O24	Structure of the foamy viral protease-reverse transcriptase in complex with dsDNA. 分子名称: DNA (5'-D(*AP*AP*CP*AP*GP*AP*GP*TP*GP*CP*GP*AP*CP*AP*CP*CP*TP*GP*AP*TP*TP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), Pr125Pol 著者 Nowotny, M, Czarnocki-Cieciura, M. 登録日 2021-03-30 公開日 2021-06-30 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase. J.Virol., 95, 2021
5ZAD	Human topoisomerase II beta in complex with DNA 分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta 著者 Sun, L.Y, Zhu, L.W, Tang, Y.J. 登録日 2018-02-07 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin. Sci Rep, 8, 2018
8E9A	Crystal structure of AsfvPolX in complex with 10-23 DNAzyme and Mg 分子名称: DNA/RNA (52-MER), MAGNESIUM ION, Repair DNA polymerase X, ... 著者 Cramer, E.R, Robart, A.R, Kaya, A.I. 登録日 2022-08-26 公開日 2023-06-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structure of a 10-23 deoxyribozyme exhibiting a homodimer conformation. Commun Chem, 6, 2023
5HSO	Crystal structure of MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN Rv2887 complex with DNA 分子名称: DNA (30-MER), the upstream sequence of Rv0560c, Uncharacterized HTH-type transcriptional regulator Rv2887 著者 Gao, Y.R, Li, D.F, Wang, D.C, Bi, L.J. 登録日 2016-01-26 公開日 2017-02-01 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Sci Rep, 7, 2017
6S6V	Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS 分子名称: MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ... 著者 Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P. 登録日 2019-07-03 公開日 2019-09-04 最終更新日 2019-11-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol.Cell, 76, 2019
7DVV	Heme sensor protein PefR from Streptococcus agalactiae bound to operator DNA (28-mer) 分子名称: DNA (28-MER), HTH marR-type domain-containing protein 著者 Nishinaga, M, Nagai, S, Nishitani, Y, Sugimoto, H, Shiro, Y, Sawai, H. 登録日 2021-01-15 公開日 2021-09-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival. Commun Biol, 4, 2021

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