PDB: 12060 件ウェブページステータス検索Chemie searchBIRD

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4CI3	Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide 分子名称: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... 著者 Fischer, E.S, Boehm, K, Thoma, N.H. 登録日 2013-12-05 公開日 2014-07-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
3OFJ	Crystal structure of N-methyltransferase NodS from Bradyrhizobium japonicum WM9 分子名称: Nodulation protein S 著者 Cakici, O, Sikorski, M, Stepkowski, T, Bujacz, G, Jaskolski, M. 登録日 2010-08-15 公開日 2010-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Crystal Structures of NodS N-Methyltransferase from Bradyrhizobium japonicum in Ligand-Free Form and as SAH Complex. J.Mol.Biol., 404, 2010
4FQK	Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8059 Heavy Chain, ... 著者 Dreyfus, C, Laursen, N.S, Wilson, I.A. 登録日 2012-06-25 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (5.65 Å) 主引用文献 Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
4FQJ	Influenza B/Florida/4/2006 hemagglutinin Fab CR8071 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, antibody CR8071 heavy chain, ... 著者 Dreyfus, C, Laursen, N.S, Wilson, I.A. 登録日 2012-06-25 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
4FQY	Crystal structure of broadly neutralizing antibody CR9114 bound to H3 influenza hemagglutinin 分子名称: Antibody CR9114 heavy chain, Antibody CR9114 light chain, Hemagglutinin HA1, ... 著者 Ekiert, D.C, Dreyfus, C, Wilson, I.A. 登録日 2012-06-25 公開日 2012-08-22 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (5.253 Å) 主引用文献 Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
4FQI	Crystal Structure of Fab CR9114 in Complex with a H5N1 influenza virus hemagglutinin 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dreyfus, C, Wilson, I.A. 登録日 2012-06-25 公開日 2012-08-22 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
3PFF	Truncated human atp-citrate lyase with ADP and tartrate bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, L(+)-TARTARIC ACID, ... 著者 Fraser, M.E, Sun, T. 登録日 2010-10-28 公開日 2011-10-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr.,Sect.F, 67, 2011
4FS4	Structure of BACE Bound to (S)-4-(3'-methoxy-[1,1'-biphenyl]-3-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-iminium 分子名称: (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one, Beta-secretase 1, L(+)-TARTARIC ACID 著者 Strickland, C, Stamford, A. 登録日 2012-06-26 公開日 2012-10-10 最終更新日 2014-07-23 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase. ACS Med Chem Lett, 3, 2012
4GAV	Structure of the Ndi1 protein from Saccharomyces cerevisiae in complex with quinone 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Rotenone-insensitive NADH-ubiquinone oxidoreductase, UBIQUINONE-2 著者 Iwata, M, Lee, Y, Yamashita, T, Yagi, T, Iwata, S, Cameron, A.D, Maher, M.J. 登録日 2012-07-25 公開日 2012-09-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates. Proc.Natl.Acad.Sci.USA, 109, 2012
8FFX	Crystal structure of HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 19980 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Reverse transcriptase/ribonuclease H, ... 著者 Rumrill, S.R, Ruiz, F.X, Arnold, E. 登録日 2022-12-10 公開日 2023-04-26 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach. Molecules, 28, 2023
5OVR	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-29 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
6OF5	The crystal structure of dodecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... 著者 Feder, D, Schenk, G, Guddat, L.W, Hussein, W.M, McGeary, R.P. 登録日 2019-03-28 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182, 2019
5OVX	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{S})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-30 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
5OW1	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [[3-(3-cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-30 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
6OWE	Enoyl-CoA carboxylases/reductases in complex with ethylmalonyl CoA 分子名称: 5'-O-[(S)-{[(S)-[(3R)-4-({(1E)-3-[(2-{[(2S)-2-carboxybutanoyl]sulfanyl}ethyl)amino]-3-oxoprop-1-en-1-yl}amino)-3-hydroxy-2,2-dimethyl-4-oxobutoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine 3'-(dihydrogen phosphate), Crotonyl-CoA carboxylase/reductase, IMIDAZOLE, ... 著者 DeMirci, H. 登録日 2019-05-09 公開日 2019-06-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Four amino acids define the CO2binding pocket of enoyl-CoA carboxylases/reductases. Proc.Natl.Acad.Sci.USA, 116, 2019
4HW1	Multiple Crystal structures of an all-AT DNA dodecamer stabilized by weak interactions. 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*AP*TP*TP*TP*AP*TP*T)-3'), MAGNESIUM ION 著者 Acosta-Reyes, F, Subirana, J.A, Pous, J, Condom, N, Malinina, L, Campos, J.L. 登録日 2012-11-07 公開日 2013-11-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Polymorphic crystal structures of an all-AT DNA dodecamer. Biopolymers, 103, 2015
6OB1	Structure of WHB in complex with Ubiquitin Variant 分子名称: Anaphase-promoting complex subunit 2, Ubiquitin 著者 Edmond, R.W, Grace, C.R. 登録日 2019-03-19 公開日 2019-08-14 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
5PTI	STRUCTURE OF BOVINE PANCREATIC TRYPSIN INHIBITOR. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT OF CRYSTAL FORM II 分子名称: PHOSPHATE ION, TRYPSIN INHIBITOR, UNKNOWN ATOM OR ION 著者 Wlodawer, A, Huber, R. 登録日 1984-10-05 公開日 1984-10-29 最終更新日 2018-10-24 実験手法 NEUTRON DIFFRACTION (1 Å), X-RAY DIFFRACTION 主引用文献 Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray refinement of crystal form II J.Mol.Biol., 180, 1984
6PCA	Crystal structure of beta-ketoadipyl-CoA thiolase 分子名称: ACETATE ION, Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, ... 著者 Sukritee, B, Panjikar, S. 登録日 2019-06-17 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase. J Struct Biol X, 4, 2020
8G5C	Structure of ACLY-D1026A-substrates, local refinement of ASH domain 分子名称: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... 著者 Xuepeng, W, Ronen, M. 登録日 2023-02-12 公開日 2023-05-10 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.2 Å) 主引用文献 Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
8G92	Structure of inhibitor 16d-bound SPNS2 分子名称: 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 著者 Chen, H, Li, X. 登録日 2023-02-21 公開日 2023-05-24 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
8G5D	Structure of ACLY-D1026A-products, local refinement of ASH domain 分子名称: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Wei, X, Marmorstein, R. 登録日 2023-02-13 公開日 2023-05-10 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
6PFN	Succinyl-CoA synthase from Francisella tularensis 分子名称: 1,2-ETHANEDIOL, ACETATE ION, COENZYME A, ... 著者 Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2019-06-21 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Succinyl-CoA synthase from Francisella tularensis to be published
6PCB	Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex with COA 分子名称: Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, COENZYME A, ... 著者 Sukritee, B, Panjikar, S. 登録日 2019-06-17 公開日 2020-05-27 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase. J Struct Biol X, 4, 2020
4J4R	Hexameric SFTSVN 分子名称: Nucleocapsid protein 著者 Jiao, L, Ouyang, S, Liang, M, Niu, F, Shaw, N, Wu, W, Ding, W, Jin, C, Zhu, Y, Zhang, F, Wang, T, Li, C, Zuo, X, Luan, C.H, Li, D, Liu, Z.J. 登録日 2013-02-07 公開日 2013-05-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol., 87, 2013

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