6Y4J
 
 | | Engineered Fructosyl Peptide Oxidase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase, GLYCEROL, ... | | 著者 | Donini, S, Rigoldi, F, Gautieri, A, Parisini, E. | | 登録日 | 2020-02-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Rational backbone redesign of a fructosyl peptide oxidase to widen its active site access tunnel.
Biotechnol.Bioeng., 117, 2020
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7P8W
 | | Human erythrocyte catalase cryoEM | | 分子名称: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Chen, S, Li, J, Vinothkumar, K.R, Henderson, R. | | 登録日 | 2021-07-23 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Interaction of human erythrocyte catalase with air-water interface in cryoEM.
Microscopy (Oxf), 71, 2022
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7OYA
 | | Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | | 登録日 | 2021-06-24 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023
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7OYB
 | | Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | | 登録日 | 2021-06-24 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023
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8EJN
 | | Structure of dehaloperoxidase A in complex with 2,4-dichlorophenol | | 分子名称: | 2,4-dichlorophenol, DIMETHYL SULFOXIDE, Dehaloperoxidase A, ... | | 著者 | Aktar, M.S, de Serrano, V.S, Franzen, S. | | 登録日 | 2022-09-17 | | 公開日 | 2023-08-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.481 Å) | | 主引用文献 | Comparative study of the binding and activation of 2,4-dichlorophenol by dehaloperoxidase A and B.
J.Inorg.Biochem., 247, 2023
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5T1F
 | | Crystal structure of Phaeospaeria nodrum fructosyl peptide oxidase mutant Asn56Ala | | 分子名称: | ACETIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Uncharacterized protein | | 著者 | Yoshida, H, Shimasaki, T, Kamitori, S, Sode, K. | | 登録日 | 2016-08-19 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | X-ray structures of fructosyl peptide oxidases revealing residues responsible for gating oxygen access in the oxidative half reaction
Sci Rep, 7, 2017
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5T1E
 | | Crystal structure of Phaeospaeria nodrum fructosyl peptide oxidase | | 分子名称: | ACETIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Uncharacterized protein | | 著者 | Yoshida, H, Shimasaki, T, Kamitori, S, Sode, K. | | 登録日 | 2016-08-19 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | X-ray structures of fructosyl peptide oxidases revealing residues responsible for gating oxygen access in the oxidative half reaction
Sci Rep, 7, 2017
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3S3Q
 | | Structure of cathepsin B1 from Schistosoma mansoni in complex with K11017 inhibitor | | 分子名称: | ACETATE ION, Cathepsin B-like peptidase (C01 family), N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide | | 著者 | Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. | | 登録日 | 2011-05-18 | | 公開日 | 2011-08-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
J.Biol.Chem., 286, 2011
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8HID
 | | HUMAN ERYTHROCYTE CATALSE COMPLEXED WITH BT-Br | | 分子名称: | (~{S})-azanyl-[2-[[3-bromanyl-4-(diethylamino)phenyl]methyl]hydrazinyl]methanethiol, Catalase, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Lin, H.-Y, Yang, G.-F. | | 登録日 | 2022-11-19 | | 公開日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A catalase inhibitor: Targeting the NADPH-binding site for castration-resistant prostate cancer therapy.
Redox Biol, 63, 2023
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8HO4
 | | Falcilysin in complex with MMV000848 | | 分子名称: | (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, Falcilysin, ... | | 著者 | Lin, J.Q, Chung, Z, Lescar, J. | | 登録日 | 2022-12-09 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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8HO5
 | | Falcilysin in complex with MMV665806 | | 分子名称: | (2S)-1-(2,3-dimethyl-1H-indol-1-yl)-3-{[(1S,2S)-2-methylcyclohexyl]amino}propan-2-ol, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Lin, J.Q, Chung, Z, Lescar, J. | | 登録日 | 2022-12-09 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Cell Chem Biol, 31, 2024
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8PVD
 | | Structure of catalase determined by cryoEM at 100 keV | | 分子名称: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | | 登録日 | 2023-07-17 | | 公開日 | 2023-11-29 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure determination by cryoEM at 100 keV.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6JW9
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1W6I
 | | plasmepsin II-pepstatin A complex | | 分子名称: | PEPSTATIN, PLASMEPSIN 2 PRECURSOR | | 著者 | Lindberg, J, Johansson, P.-O, Rosenquist, A, Kvarnstroem, I, Vrang, L, Samuelsson, B, Unge, T. | | 登録日 | 2004-08-18 | | 公開日 | 2006-07-05 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Study of a Novel Inhibitor with Bulky P1 Side Chain in Complex with Plasmepsin II -Implications for Drug Design
To be Published
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1W6H
 | | Novel plasmepsin II-inhibitor complex | | 分子名称: | N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE, PLASMEPSIN 2 | | 著者 | Lindberg, J, Johansson, P.-O, Rosenquist, A, Kvarnstroem, I, Vrang, L, Samuelsson, B, Unge, T. | | 登録日 | 2004-08-18 | | 公開日 | 2006-07-05 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Structural Study of a Novel Inhibitor with Bulky P1 Side Chain in Complex with Plasmepsin II -Implications for Drug Design
To be Published
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4YZF
 | | Crystal structure of the anion exchanger domain of human erythrocyte Band 3 | | 分子名称: | 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid}, Band 3 anion transport protein, FAB fragment of Immunoglobulin (IgG) molecule | | 著者 | Alguel, Y, Arakawa, T, Yugiri, T.K, Iwanari, H, Hatae, H, Iwata, M, Abe, Y, Hino, T, Suno, C.I, Kuma, H, Kang, D, Murata, T, Hamakubo, T, Cameron, A.D, Kobayashi, T, Hamasaki, N, Iwata, S. | | 登録日 | 2015-03-25 | | 公開日 | 2015-11-04 | | 最終更新日 | 2015-11-18 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal structure of the anion exchanger domain of human erythrocyte band 3.
Science, 350, 2015
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6TLB
 | | Plasmodium falciparum lipocalin (PF3D7_0925900) | | 分子名称: | GLYCEROL, SODIUM ION, Serine/threonine protein kinase | | 著者 | Burda, P.C, Crosskey, T.D, Lauk, K, Wilmanns, M, Gilberger, T.W. | | 登録日 | 2019-12-02 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | SOLUTION SCATTERING (2.85 Å), X-RAY DIFFRACTION | | 主引用文献 | Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum.
Cell Rep, 31, 2020
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6WVV
 | | Plasmodium vivax M17 leucyl aminopeptidase | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, M17 leucyl aminopeptidase, ... | | 著者 | Malcolm, T.R, Drinkwater, N, McGowan, S. | | 登録日 | 2020-05-07 | | 公開日 | 2020-12-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
J.Biol.Chem., 296, 2020
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7N3S
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7N3R
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5HLY
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8BLX
 | | Engineered Fructosyl Peptide Oxidase - X02A mutant | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (X02A), ... | | 著者 | Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. | | 登録日 | 2022-11-10 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition.
Sci Rep, 13, 2023
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8BJY
 | | Engineered Fructosyl Peptide Oxidase - X02B mutant | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (X02B), GLYCEROL | | 著者 | Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. | | 登録日 | 2022-11-08 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.475 Å) | | 主引用文献 | Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition.
Sci Rep, 13, 2023
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8BLZ
 | | Engineered Fructosyl Peptide Oxidase - D02 mutant | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (D02), GLYCEROL, ... | | 著者 | Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. | | 登録日 | 2022-11-10 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition.
Sci Rep, 13, 2023
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8BMU
 | | Engineered Fructosyl Peptide Oxidase - X04 mutant | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Fructosyl Peptide Oxidase mutant (X04), ... | | 著者 | Estiri, H, Bhattacharya, S, Rodriguez-Buitrago, J.A, Parisini, E. | | 登録日 | 2022-11-11 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition.
Sci Rep, 13, 2023
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