PDB: 183283 件ウェブページステータス検索Chemie searchBIRD

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6WR0	Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog 分子名称: (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Petrunak, E.M, Bart, A.G, Scott, E.E. 登録日 2020-04-29 公開日 2021-05-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
8PYV	Structure of Human PS-1 GSH-analog complex, solved at wavelength 2.755 A 分子名称: L-gamma-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-L-cysteinylglycine, PALMITIC ACID, Prostaglandin E synthase 著者 Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Wagner, A, Vogeley, L, Brown, D.G. 登録日 2023-07-26 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Experimental phasing opportunities for macromolecular crystallography at very long wavelengths. Commun Chem, 6, 2023
5JQU	Crystal structure of Cytochrome P450 BM3 heme domain G265F/T269V/L272W/L322I/F405M/A406S (WIVS-FM) variant with iron(III) deuteroporphyrin IX bound 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, FE(III) DEUTEROPORPHYRIN IX 著者 Reynolds, E.W, McHenry, M.W, Cannac, F, Gober, J.G, Snow, C.D, Brustad, E.M. 登録日 2016-05-05 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.162 Å) 主引用文献 An Evolved Orthogonal Enzyme/Cofactor Pair. J.Am.Chem.Soc., 138, 2016
1GT7	L-rhamnulose-1-phosphate aldolase from Escherichia coli 分子名称: PHOSPHOGLYCOLOHYDROXAMIC ACID, RHAMNULOSE-1-PHOSPHATE ALDOLASE, ZINC ION 著者 Kroemer, M, Schulz, G.E. 登録日 2002-01-14 公開日 2002-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Structure of L-Rhamnulose-1-Phosphate Aldolase (Class II) Solved by Low-Resolution Sir Phasing and 20-Fold Ncs Averaging Acta Crystallogr.,Sect.D, 58, 2002
6WW0	Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog 分子名称: (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Petrunak, E.M, Bart, A.G, Scott, E.E. 登録日 2020-05-07 公開日 2021-05-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
6QZ1	Structure of MHETase from Ideonella sakaiensis 分子名称: BENZOIC ACID, CALCIUM ION, Mono(2-hydroxyethyl) terephthalate hydrolase 著者 Allen, M.D, Johnson, C.W, Knott, B.C, Beckham, G.T, McGeehan, J.E. 登録日 2019-03-10 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Characterization and engineering of a two-enzyme system for plastics depolymerization. Proc.Natl.Acad.Sci.USA, 117, 2020
6O8Z	Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class04 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Jogl, G, Khayat, R. 登録日 2019-03-12 公開日 2020-09-16 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis. Sci Rep, 10, 2020
5KND	Crystal structure of the Pi-bound V1 complex 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ... 著者 Suzuki, K, Mizutani, K, Maruyama, S, Shimono, K, Imai, F.L, Muneyuki, E, Kakinuma, Y, Ishizuka-Katsura, Y, Shirouzu, M, Yokoyama, S, Yamato, I, Murata, T. 登録日 2016-06-28 公開日 2016-11-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.888 Å) 主引用文献 Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor Nat Commun, 7, 2016
4U9M	Structure of the DNA duplex d(ATTAAT)2 with Hoogsteen hydrogen bonds 分子名称: DNA (5'-D(*AP*TP*TP*AP*AP*T)-3') 著者 Acosta-Reyes, F.J, Alechaga, E, Subirana, J.A, Campos, J.L. 登録日 2014-08-06 公開日 2015-04-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Structure of the DNA Duplex d(ATTAAT)2 with Hoogsteen Hydrogen Bonds. Plos One, 10, 2015
4TVX	Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade 分子名称: CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... 著者 Jackson, R.N, Golden, S.M, Carter, J, Wiedenheft, B. 登録日 2014-06-28 公開日 2014-08-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science, 345, 2014
8U8Q	V290N/S292F Streptomyces coelicolor Laccase 分子名称: BORIC ACID, COPPER (II) ION, Copper oxidase, ... 著者 Wang, J.-X, Lu, Y. 登録日 2023-09-18 公開日 2023-11-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations. Angew.Chem.Int.Ed.Engl., 62, 2023
6R6F	Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide 分子名称: 4-chloranyl-2-cyclohexylsulfanyl-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2019-03-27 公開日 2019-12-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
8U8P	S292F Streptomyces coelicolor Laccase 分子名称: BORIC ACID, COPPER (II) ION, Copper oxidase, ... 著者 Wang, J.-X, Lu, Y. 登録日 2023-09-18 公開日 2023-11-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations. Angew.Chem.Int.Ed.Engl., 62, 2023
8U8S	Y229F/S292F Streptomyces coelicolor Laccase 分子名称: BORIC ACID, COPPER (II) ION, Copper oxidase, ... 著者 Wang, J.-X, Lu, Y. 登録日 2023-09-18 公開日 2023-11-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations. Angew.Chem.Int.Ed.Engl., 62, 2023
8U8T	Y229F/V290N Streptomyces coelicolor Laccase 分子名称: BORIC ACID, COPPER (II) ION, Copper oxidase, ... 著者 Wang, J.-X, Lu, Y. 登録日 2023-09-18 公開日 2023-11-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations. Angew.Chem.Int.Ed.Engl., 62, 2023
8U8R	Y229F/V290N/S292F Streptomyces coelicolor Laccase 分子名称: BORIC ACID, COPPER (II) ION, Copper oxidase, ... 著者 Wang, J.-X, Lu, Y. 登録日 2023-09-18 公開日 2023-11-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations. Angew.Chem.Int.Ed.Engl., 62, 2023
5L8C	Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-039 分子名称: 4-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(2-azanyl-2-oxidanylidene-ethyl)benzamide, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... 著者 Singh, A.K, Anthonyrajah, E.S, Brown, D.G. 登録日 2016-06-07 公開日 2018-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. J. Med. Chem., 61, 2018
8P2Z	Structure of human SIT1 bound to L-pipecolate (focussed map / refinement) 分子名称: (2S)-piperidine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B. 登録日 2023-05-16 公開日 2024-06-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. Nat Commun, 15, 2024
1H48	The structure of 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase in complex with CMP and product 分子名称: 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE, CYTIDINE-5'-MONOPHOSPHATE, ... 著者 Kemp, L.E, Alphey, M.S, Bond, C.S, Hunter, W.N. 登録日 2003-02-24 公開日 2004-12-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods Acta Crystallogr.,Sect.D, 61, 2005
8UEE	Atomic structure of Salmonella SipA/F-actin complex by cryo-EM 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... 著者 Niedzialkowska, E, Runyan, L, Kudryashova, E, Kudryashov, D.S, Egelman, E.H. 登録日 2023-10-01 公開日 2023-12-27 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin. Structure, 32, 2024
8UDV	The X-RAY co-crystal structure of human FGFR3 V555M and Compound 17 分子名称: 1,2-ETHANEDIOL, 3-[(6-chloro-1-cyclopropyl-1H-benzimidazol-5-yl)ethynyl]-1-[(3S,5S)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide, Fibroblast growth factor receptor 3, ... 著者 Tyhonas, J.S, Arnold, L.D, Cox, J, Franovic, A, Gardiner, E, Grandinetti, K, Kania, R, Kanouni, T, Lardy, M, Li, C, Martin, E.S, Miller, N, Mohan, A, Murphy, E.A, Perez, M, Soroceanu, L, Timple, N, Uryu, S, Womble, S, Kaldor, S.W. 登録日 2023-09-29 公開日 2024-02-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.348 Å) 主引用文献 Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations. J.Med.Chem., 67, 2024
8QU9	Structure of the NCOA4 (Nuclear Receptor Coactivator 4)-FTH1 (H-Ferritin) complex 分子名称: FE (III) ION, Ferritin heavy chain, NCOA4 (Nuclear Receptor Coactivator 4) 著者 Hoelzgen, F, Klukin, E, Zalk, R, Shahar, A, Cohen-Schwartz, S, Frank, G.A. 登録日 2023-10-15 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Structural basis for the intracellular regulation of ferritin degradation. Nat Commun, 15, 2024
2HMI	HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28/DNA COMPLEX 分子名称: DNA (5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3'), FAB FRAGMENT OF MONOCLONAL ANTIBODY 28, ... 著者 Ding, J, Arnold, E. 登録日 1998-04-10 公開日 1998-10-14 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. J.Mol.Biol., 284, 1998
1HQA	ALKALINE PHOSPHATASE (H412Q) 分子名称: ALKALINE PHOSPHATASE, ZINC ION 著者 Ma, L, Kantrowitz, E.R. 登録日 1995-11-30 公開日 1996-03-08 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites. Biochemistry, 35, 1996
6DF9	Kaiso (ZBTB33) E535Q zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS) 分子名称: CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... 著者 Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. 登録日 2018-05-14 公開日 2019-05-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.319 Å) 主引用文献 A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences. Biochemistry, 2020

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