6R6F
Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Summary for 6R6F
Entry DOI | 10.2210/pdb6r6f/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-chloranyl-2-cyclohexylsulfanyl-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide, ... (5 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal binding protein, lyase-lyase inhibitor complex, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29825.53 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-03-27, release date: 2019-12-18, Last modification date: 2024-01-24) |
Primary citation | Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Paketuryte, V.,Smirnov, A.,Leitans, J.,Kazaks, A.,Dvinskis, E.,Manakova, E.,Grazulis, S.,Tars, K.,Matulis, D. Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185:111825-111825, 2020 Cited by PubMed: 31740053DOI: 10.1016/j.ejmech.2019.111825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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