7PI9
 
 | | 70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-19 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PPH
 | | CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH Compound 10 | | 分子名称: | GLYCEROL, N-[4-[(5R)-6-oxidanylidene-5-quinolin-5-yl-5-(trifluoromethyl)-1,4-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | 著者 | Hillig, R.C. | | 登録日 | 2021-09-13 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
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7PIB
 | | 70S ribosome with EF-G, A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-19 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PPI
 | | Crystal STRUCTURE OF NAMPT IN COMPLEX WITH Compound 11 | | 分子名称: | CHLORIDE ION, GLYCEROL, N-[4-[(5R)-1-(4-azanylbutyl)-6-oxidanylidene-5-quinolin-5-yl-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, ... | | 著者 | Hillig, R.C. | | 登録日 | 2021-09-13 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
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7PPE
 | | CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 1 | | 分子名称: | GLYCEROL, N-[4-[(4R)-4-methyl-1-(oxan-4-yl)-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | 著者 | Hillig, R.C. | | 登録日 | 2021-09-13 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
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7PPF
 | | CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 8 | | 分子名称: | 1,2-ETHANEDIOL, N-[4-[(4R)-1,4-dimethyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | 著者 | Hillig, R.C. | | 登録日 | 2021-09-13 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
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7Q3B
 | | Crystal structure of human STING in complex with 3'3'-c-(2'F,2'dA-isonucA)MP | | 分子名称: | 3'3'-c-(2'F,2'dA-isonucA)MP, Stimulator of interferon genes protein | | 著者 | Smola, M, Klima, M, Boura, E. | | 登録日 | 2021-10-27 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.55733919 Å) | | 主引用文献 | Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Structure, 30, 2022
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7Q6C
 | | complement C6 FIM1-2 bound to CP010 antibody | | 分子名称: | ACETATE ION, CP010 heavy chain, CP010 light chain, ... | | 著者 | Olesen, H.G, Andersen, G.R. | | 登録日 | 2021-11-06 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.29274 Å) | | 主引用文献 | Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.
J Innate Immun, 2022
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7PIP
 | | 70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-23 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PIR
 | | 70S ribosome with A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-23 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (12.1 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PPG
 | | CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 9 | | 分子名称: | 1,2-ETHANEDIOL, N-[4-[(4R)-1-cyclopentyl-4-methyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | 著者 | Hillig, R.C. | | 登録日 | 2021-09-13 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
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7QPU
 | | Botulinum neurotoxin A5 cell binding domain in complex with GM1b oligosaccharide | | 分子名称: | Botulinum neurotoxin sub-type A5, DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, ... | | 著者 | Gregory, K.S, Acharya, K.R, Liu, S.M. | | 登録日 | 2022-01-05 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structures of Botulinum Neurotoxin Subtypes A4 and A5 Cell Binding Domains in Complex with Receptor Ganglioside.
Toxins, 14, 2022
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7Q96
 | | Keap1 compound complex | | 分子名称: | 4-[(5S,8R)-5-(dimethylcarbamoyl)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-trien-16-yl]benzoic acid, CHLORIDE ION, Kelch-like ECH-associated protein 1 | | 著者 | Johansson, P. | | 登録日 | 2021-11-12 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.415 Å) | | 主引用文献 | Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
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7Q6Q
 | | Keap1 compound complex | | 分子名称: | (5S,8R)-N,N-dimethyl-8-[[(2S)-1-[4-(methylamino)-4-oxidanylidene-butanoyl]pyrrolidin-2-yl]carbonylamino]-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(12),13,15-triene-5-carboxamide, CHLORIDE ION, Kelch-like ECH-associated protein 1, ... | | 著者 | Johansson, P. | | 登録日 | 2021-11-09 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
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7Q6S
 | | Keap1 compound complex | | 分子名称: | (5S,8R)-16-(2,1,3-benzoxadiazol-4-yl)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-N,N-dimethyl-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-5-carboxamide, CHLORIDE ION, Kelch-like ECH-associated protein 1 | | 著者 | Johansson, P. | | 登録日 | 2021-11-09 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.143 Å) | | 主引用文献 | Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
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7QPT
 | | Botulinum neurotoxin A4 cell binding domain in complex with GD1a oligosaccharide | | 分子名称: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, Neurotoxin type A | | 著者 | Gregory, K.S, Acharya, K.R, Liu, S.M, Mojanaga, O.O. | | 登録日 | 2022-01-05 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structures of Botulinum Neurotoxin Subtypes A4 and A5 Cell Binding Domains in Complex with Receptor Ganglioside.
Toxins, 14, 2022
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7Q8R
 | | Keap1 compound complex | | 分子名称: | 3-[(5S,8R)-5-(dimethylcarbamoyl)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-trien-16-yl]benzoic acid, CHLORIDE ION, Kelch-like ECH-associated protein 1 | | 著者 | Johansson, P. | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.282 Å) | | 主引用文献 | Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
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7RJ8
 | | CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 ISOFORM 1 COMPLEXED WITH LIGAND (2R)-2-AMINO-N-[3-(DIFLUOROM ETHOXY)-4-(1,3-OXAZOL-5-YL)PHENYL]-4-METHYLPENTANAMIDE | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine, AP2-associated protein kinase 1, ... | | 著者 | Pokross, M, Muckelbauer, J. | | 登録日 | 2021-07-20 | | 公開日 | 2022-02-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J.Med.Chem., 65, 2022
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7RJ6
 | | CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 ISOFORM 1 COMPLEXED WITH LIGAND (2R)-2-AMINO-N-[3-(DIFLUOROM ETHOXY)-4-(1,3-OXAZOL-5-YL)PHENYL]-4-METHYLPENTANAMIDE | | 分子名称: | (1S)-1-[4-ethyl-6-(1,3-oxazol-5-yl)quinazolin-2-yl]-3-methylbutan-1-amine, 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine, AP2-associated protein kinase 1, ... | | 著者 | Muckelbauer, J. | | 登録日 | 2021-07-20 | | 公開日 | 2022-02-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.132 Å) | | 主引用文献 | Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J.Med.Chem., 65, 2022
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7RJ7
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7PI8
 | | 70S ribosome with P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-19 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (8.9 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PIC
 | | 70S ribosome with P/E-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-19 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (9.1 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PIA
 | | 70S ribosome with A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-19 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (13.6 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PIS
 | | 70S ribosome with EF-G, A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-23 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (15 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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7PIQ
 | | 70S ribosome with A- and P-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | 登録日 | 2021-08-23 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (9.7 Å) | | 主引用文献 | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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