7TLQ
 
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6PF9
 | | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid. | | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, METHOTREXATE, ... | | 著者 | Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. | | 登録日 | 2019-06-21 | | 公開日 | 2019-10-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.
Eur.J.Med.Chem., 183, 2019
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8GDC
 | | Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein | | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Shenming, H, Mengyao, X, Lei, L, Yang, D, Shiyi, G, Jinpeng, S. | | 登録日 | 2023-03-03 | | 公開日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
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5MY8
 | | Crystal structure of SRPK1 in complex with SPHINX31 | | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ... | | 著者 | Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2017-01-25 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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7X2E
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2YFN
 | | galactosidase domain of alpha-galactosidase-sucrose kinase, AgaSK | | 分子名称: | 1,2-ETHANEDIOL, ALPHA-GALACTOSIDASE-SUCROSE KINASE AGASK, GLYCEROL, ... | | 著者 | Sulzenbacher, G, Bruel, L, Tison-Cervera, M, Pujol, A, Nicoletti, C, Perrier, J, Galinier, A, Ropartz, D, Fons, M, Pompeo, F, Giardina, T. | | 登録日 | 2011-04-07 | | 公開日 | 2011-09-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Agask, a Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities
J.Biol.Chem., 286, 2011
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5N23
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6W2D
 | | Structures of Capsid and Capsid-Associated Tegument Complex inside the Epstein-Barr Virus | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | | 著者 | Liu, W, Cui, Y.X, Wang, C.Y, Li, Z.H, Gong, D.Y, Dai, X.H, Bi, G.Q, Sun, R, Zhou, Z.H. | | 登録日 | 2020-03-05 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.
Nat Microbiol, 5, 2020
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6P9Y
 | | PAC1 GPCR Receptor complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. | | 登録日 | 2019-06-10 | | 公開日 | 2020-02-05 | | 最終更新日 | 2020-02-19 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol.Cell, 77, 2020
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3WIN
 | | Clostridium botulinum Hemagglutinin | | 分子名称: | 17 kD hemagglutinin component, HA1, HA3 | | 著者 | Amatsu, S, Sugawara, Y, Matsumura, T, Fujinaga, Y, Kitadokoro, K. | | 登録日 | 2013-09-19 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal Structure of Clostridium botulinum Whole Hemagglutinin Reveals a Huge Triskelion-shaped Molecular Complex
J.Biol.Chem., 288, 2013
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6VPF
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6PFG
 | | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-carbamoylbenzoic acid. | | 分子名称: | 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-carbamoylbenzoic acid, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | 著者 | Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. | | 登録日 | 2019-06-21 | | 公開日 | 2019-10-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.706 Å) | | 主引用文献 | Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.
Eur.J.Med.Chem., 183, 2019
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7QPD
 | | Structure of the human MHC I peptide-loading complex editing module | | 分子名称: | Beta-2-microglobulin, Calreticulin, HLA class I histocompatibility antigen, ... | | 著者 | Domnick, A, Susac, L, Trowitzsch, S, Thomas, C, Tampe, R. | | 登録日 | 2022-01-03 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Molecular basis of MHC I quality control in the peptide loading complex.
Nat Commun, 13, 2022
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7TIT
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7TJ7
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7TIJ
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5NBT
 | | Apo structure of p60N/p80C katanin | | 分子名称: | Katanin p60 ATPase-containing subunit A1, Katanin p80 WD40 repeat-containing subunit B1 | | 著者 | Jiang, K, Rezabkova, L, Hua, S, Liu, Q, Capitani, G, Altelaar, A.F.M, Heck, A.J.R, Kammerer, R.A, Steinmetz, M.O, Akhmanova, A. | | 登録日 | 2017-03-02 | | 公開日 | 2017-04-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
Nat. Cell Biol., 19, 2017
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3WTP
 | | Crystal Structure of the heterotypic nucleosome containing human CENP-A and H3.3 | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Arimura, Y, Shirayama, K, Horikoshi, N, Fujita, R, Kagawa, W, Fukagawa, T, Almouzni, G, Kurumizaka, H. | | 登録日 | 2014-04-14 | | 公開日 | 2014-12-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3
Sci Rep, 4, 2014
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8HS2
 | | Orphan GPR20 in complex with Fab046 | | 分子名称: | Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 | | 著者 | Lin, X, Jiang, S, Xu, F. | | 登録日 | 2022-12-16 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20.
Cell Discov, 9, 2023
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7XAB
 | | Crystal structure of PDE4D catalytic domain complexed with compound 22d | | 分子名称: | 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | | 登録日 | 2022-03-17 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.00067449 Å) | | 主引用文献 | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.
Eur.J.Med.Chem., 242, 2022
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7BC6
 | | Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 | | 分子名称: | Proton-coupled folate transporter, nanobody | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2020-12-18 | | 公開日 | 2021-05-12 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
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8H50
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7BC7
 | | Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed | | 分子名称: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Proton-coupled folate transporter, nanobody | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2020-12-18 | | 公開日 | 2021-05-12 | | 最終更新日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
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3WYY
 | | CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH (E)-3-(4-((6-(((3s,5s,7s)-adamantan-1-yl)amino)-4-amino-5-cyanopyridin-2-yl)amino)-2-(cyanomethoxy)phenyl)-N-(2-methoxyethyl)acrylamide | | 分子名称: | (2E)-3-[4-({4-amino-5-cyano-6-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylamino]pyridin-2-yl}amino)-2-(cyanomethoxy)phenyl]-N-(2-methoxyethyl)prop-2-enamide, Dual specificity protein kinase TTK | | 著者 | Kusakabe, K, Ide, N, Daigo, Y, Itoh, T, Yamamoto, T, Kojima, E, Mitsuoka, Y, Tadano, G, Tagashira, S, Higashino, K, Okano, Y, Sato, Y, Inoue, M, Iguchi, M, Kanazawa, T, Ishioka, Y, Dohi, K, Kido, Y, Sakamoto, S, Ando, S, Maeda, M, Higaki, M, Yoshizawa, H, Murai, H, Nakamura, Y. | | 登録日 | 2014-09-10 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
Bioorg.Med.Chem., 23, 2015
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8H52
 | | Crystal structure of Helicobacter pylori carboxyspermidine dehydrogenase in complex with NADP | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Saccharopine dehydrogenase | | 著者 | Ko, K.Y, Park, S.C, Cho, S.Y, Yoon, S.I. | | 登録日 | 2022-10-11 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural analysis of carboxyspermidine dehydrogenase from Helicobacter pylori.
Biochem.Biophys.Res.Commun., 635, 2022
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