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2G45
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Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin
分子名称: CHLORIDE ION, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 5, ...
著者Reyes-Turcu, F.E, Horton, J.R, Mullally, J.E, Heroux, A, Cheng, X, Wilkinson, K.D.
登録日2006-02-21
公開日2006-04-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
8DZM
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Crystal structure of human Sar1a in complex with ppGpp and Magnesium
分子名称: GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION
著者Huang, Q.
登録日2022-08-08
公開日2023-08-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.648 Å)
主引用文献The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
2G9X
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Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
分子名称: 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL, Cell division protein kinase 2, Cyclin-A2
著者Echalier, A, Endicott, J.A, Noble, M.E.
登録日2006-03-07
公開日2006-05-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination.
J.Am.Chem.Soc., 128, 2006
2GDJ
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Delta-62 RADA recombinase in complex with AMP-PNP and magnesium
分子名称: DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Wu, Y, Qian, X, He, Y, Luo, Y.
登録日2006-03-16
公開日2006-05-16
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Rad51/RadA N-Terminal Domain Activates Nucleoprotein Filament ATPase Activity.
Structure, 14, 2006
2GEU
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BU of 2geu by Molmil
Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A derivative, Form-II (RT)
分子名称: Pantothenate kinase, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-4-{[3-({2-[(2-HYDROXYETHYL)DITHIO]ETHYL}AMINO)-3-OXOPROPYL]AMINO}-2,2-DIMETHYL-4-OXOBUTYL DIHYDROGEN DIPHOSPHATE
著者Das, S, Kumar, P, Bhor, V, Surolia, A, Vijayan, M.
登録日2006-03-20
公開日2006-06-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Invariance and variability in bacterial PanK: a study based on the crystal structure of Mycobacterium tuberculosis PanK.
Acta Crystallogr.,Sect.D, 62, 2006
2G5Z
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BU of 2g5z by Molmil
Structure of S65G Y66S GFP variant after spontaneous peptide hydrolysis and decarboxylation
分子名称: Green fluorescent protein, MAGNESIUM ION
著者Barondeau, D.P, Kassmann, C.J, Tainer, J.A, Getzoff, E.D.
登録日2006-02-23
公開日2006-04-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Understanding GFP Posttranslational Chemistry: Structures of Designed Variants that Achieve Backbone Fragmentation, Hydrolysis, and Decarboxylation.
J.Am.Chem.Soc., 128, 2006
2GHU
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Crystal structure of falcipain-2 from Plasmodium falciparum
分子名称: falcipain 2
著者Hogg, T, Nagarajan, K, Schmidt, C.L, Hilgenfeld, R.
登録日2006-03-27
公開日2006-06-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum.
J.Biol.Chem., 281, 2006
2G6I
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Structure of rat nNOS heme domain (BH2-bound) in the reduced form
分子名称: 7,8-DIHYDROBIOPTERIN, ACETATE ION, ARGININE, ...
著者Li, H, Igarashi, J, Jamal, J, Yang, W, Poulos, T.L.
登録日2006-02-24
公開日2006-08-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2GIH
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Q138F HincII bound to cognate DNA GTCGAC and Ca2+
分子名称: 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*GP*C)-3', CALCIUM ION, Type II restriction enzyme HincII
著者Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J.
登録日2006-03-28
公開日2006-07-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
2GIS
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BU of 2gis by Molmil
Structure of the S-adenosylmethionine riboswitch mRNA regulatory element
分子名称: IRIDIUM HEXAMMINE ION, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ...
著者Montange, R.K, Batey, R.T.
登録日2006-03-29
公開日2006-07-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the S-adenosylmethionine riboswitch regulatory mRNA element.
Nature, 441, 2006
2G92
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Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
分子名称: 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3'
著者Egli, M, Li, F.
登録日2006-03-04
公開日2006-04-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
Acs Chem.Biol., 1, 2006
2G6M
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BU of 2g6m by Molmil
Structure of rat nNOS heme domain (BH4 bound) complexed with CO
分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ARGININE, ...
著者Li, H, Igarashi, J, Jamal, J, Yang, W, Poulos, T.L.
登録日2006-02-24
公開日2006-08-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G73
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Y104F mutant type 1 IPP isomerase complex with EIPP
分子名称: 4-HYDROXY-3-METHYL BUTYL DIPHOSPHATE, Isopentenyl-diphosphate delta-isomerase, MAGNESIUM ION, ...
著者de Ruyck, J, Wouters, J.
登録日2006-02-27
公開日2006-04-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.
J.Biol.Chem., 281, 2006
2G85
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BU of 2g85 by Molmil
Crystal structure of chorismate synthase from Mycobacterium tuberculosis at 2.22 angstrons of resolution
分子名称: Chorismate synthase
著者Dias, M.V.B, dos Santos, B.B, Ely, F, Basso, L.A, Santos, D.S, de Azevedo Jr, W.F.
登録日2006-03-01
公開日2007-03-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structure of chorismate synthase from Mycobacterium tuberculosis at 2.22 angstron of resolution
To be Published
2GCE
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BU of 2gce by Molmil
The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
分子名称: (R)-IBUPROFENOYL-COENZYME A, (S)-IBUPROFENOYL-COENZYME A, probable alpha-methylacyl-CoA racemase MCR
著者Bhaumik, P, Wierenga, R.K.
登録日2006-03-14
公開日2007-02-20
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface
J.Mol.Biol., 367, 2007
2GB9
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d(CGTACG)2 crosslinked bis-acridine complex
分子名称: 5'-D(*CP*GP*TP*AP*CP*G)-3', 9,9'-(HEXANE-1,6-DIYLDIIMINO)BIS{N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE}, STRONTIUM ION
著者Hopcroft, N.H, Brogden, A.L, Searcey, M, Cardin, C.J.
登録日2006-03-10
公開日2006-04-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.
Nucleic Acids Res., 34, 2006
2GC8
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Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase
分子名称: 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE, RNA-directed RNA polymerase
著者Gopalsamy, A, Chopra, R, Lim, K, Ciszewski, G, Shi, M, Curran, K.J, Sukits, S.F, Svenson, K, Bard, J, Ellingboe, J.W, Agarwal, A, Krishnamurthy, G, Howe, A.Y, Orlowski, M, Feld, B, O'connell, J, Mansour, T.S.
登録日2006-03-13
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site.
J.Med.Chem., 49, 2006
2GEZ
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BU of 2gez by Molmil
Crystal structure of potassium-independent plant asparaginase
分子名称: CHLORIDE ION, L-asparaginase alpha subunit, L-asparaginase beta subunit, ...
著者Michalska, K, Bujacz, G, Jaskolski, M.
登録日2006-03-21
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of plant asparaginase.
J.Mol.Biol., 360, 2006
2G8G
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Structurally mapping the diverse phenotype of Adeno-Associated Virus serotype 4
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Capsid
著者Govindasamy, L, Padron, E, McKenna, R, Muzyczka, N, Chiorini, J.A, Agbandje-McKenna, M.
登録日2006-03-02
公開日2007-01-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
J.Virol., 80, 2006
2GA3
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Structure of S102T E. coli Alkaline Phosphatase-phosphate intermediate at 2.20A resolution
分子名称: Alkaline phosphatase, MAGNESIUM ION, SULFATE ION, ...
著者Wang, J, Kantrowitz, E.R.
登録日2006-03-07
公開日2006-10-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
Protein Sci., 15, 2006
8EM8
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Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165
分子名称: UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ...
著者Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2022-09-27
公開日2022-11-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165
To Be Published
4V6C
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Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Zhang, W, Dunkle, J.A, Cate, J.H.D.
登録日2009-06-27
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structures of the ribosome in intermediate States of ratcheting.
Science, 325, 2009
4V7V
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Crystal structure of the E. coli ribosome bound to clindamycin.
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D.
登録日2010-08-16
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (3.2891 Å)
主引用文献Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V8G
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Crystal structure of RMF bound to the 70S ribosome.
分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
著者Polikanov, Y.S, Blaha, G.M, Steitz, T.A.
登録日2011-12-11
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
4V7L
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The structures of viomycin bound to the 70S ribosome.
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Stanley, R.E, Blaha, G.
登録日2009-11-12
公開日2014-07-09
最終更新日2018-07-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
Nat.Struct.Mol.Biol., 17, 2010

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