PDB: 19326 件ウェブページステータス検索Chemie searchBIRD

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8ECC	Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ... 著者 Wu, S, Sohn, J. 登録日 2022-09-01 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA To Be Published
2QS2	Crystal structure of the GluR5 ligand binding core dimer in complex with UBP318 at 1.80 Angstroms resolution 分子名称: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-bromo-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)thiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
2R4E	Crystal structure of Escherichia coli Glycerol-3-phosphate Dehydrogenase in complex with DHAP 分子名称: 1,2-ETHANEDIOL, 1,3-DIHYDROXYACETONEPHOSPHATE, Aerobic glycerol-3-phosphate dehydrogenase, ... 著者 Yeh, J.I, Du, S, Chinte, U. 登録日 2007-08-31 公開日 2008-04-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism. Proc.Natl.Acad.Sci.Usa, 105, 2008
6VAL	Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera 分子名称: Green fluorescent protein, CALHM1,CALMH2 chimera 著者 Syrjanen, J.L, Chou, T.H, Furukawa, H. 登録日 2019-12-17 公開日 2020-01-29 最終更新日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.87 Å) 主引用文献 Structure and assembly of calcium homeostasis modulator proteins. Nat.Struct.Mol.Biol., 27, 2020
1QXH	Crystal Structure of Escherichia coli Thiol Peroxidase in the Oxidized State 分子名称: Thiol peroxidase 著者 Choi, J, Choi, S, Choi, J, Shin, W. 登録日 2003-09-06 公開日 2004-01-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of Escherichia coli thiol peroxidase in the oxidized state: insights into intramolecular disulfide formation and substrate binding in atypical 2-Cys peroxiredoxins J.Biol.Chem., 278, 2003
1Q8T	The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632 分子名称: (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... 著者 Breitenlechner, C, Gassel, M, Hidaka, H, Kinzel, V, Huber, R, Engh, R.A, Bossemeyer, D. 登録日 2003-08-22 公開日 2003-12-16 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure, 11, 2003
2BGR	Crystal structure of HIV-1 Tat derived nonapeptides Tat(1-9) bound to the active site of Dipeptidyl peptidase IV (CD26) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Weihofen, W.A, Liu, J, Reutter, W, Saenger, W, Fan, H. 登録日 2005-01-04 公開日 2005-01-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26) J.Biol.Chem., 280, 2005
1QD8	COMPLEX OF VANCOMYCIN WITH N-ACETYL GLYCINE 分子名称: ACETYLAMINO-ACETIC ACID, CHLORIDE ION, VANCOMYCIN, ... 著者 Loll, P.J, Kaplan, J, Selinsky, B, Axelsen, P.H. 登録日 1999-07-15 公開日 1999-08-16 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Vancomycin Binding to Low-Affinity Ligands: Delineating a Minimum Set of Interactions Necessary for High-Affinity Binding. J.Med.Chem., 42, 1999
2C68	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE, CELL DIVISION PROTEIN KINASE 2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-08 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
6FJ4	Structure of FAE solved by SAD from data collected at the peak of the Selenium absorption edge on ID30B 分子名称: CADMIUM ION, Endo-1,4-beta-xylanase Y, GLYCEROL, ... 著者 McCarthy, A.A, Mueller-Dieckmann, C. 登録日 2018-01-19 公開日 2018-02-07 最終更新日 2018-08-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 ID30B - a versatile beamline for macromolecular crystallography experiments at the ESRF. J Synchrotron Radiat, 25, 2018
6FJB	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 5'-O-prop-2-yn-1-yladenosine, Mitogen-activated protein kinase 1, SULFATE ION 著者 Gelin, M, Labesse, G. 登録日 2018-01-22 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
5JYU	NMR structure of pseudo receiver domain of CikA from Thermosynechococcus elongatus 分子名称: Two-component sensor histidine kinase 著者 Tseng, R.D, LiWang, A.L. 登録日 2016-05-15 公開日 2017-03-29 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural basis of the day-night transition in a bacterial circadian clock. Science, 355, 2017
2RCB	Crystal structure of the NR3B ligand binding core complex with D-serine at 1.62 Angstrom resolution 分子名称: D-SERINE, GLYCEROL, Glutamate [NMDA] receptor subunit 3B 著者 Yao, Y, Mayer, M.L. 登録日 2007-09-19 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. Embo J., 27, 2008
6EVU	Adhesin domain of PrgB from Enterococcus faecalis 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, PrgB 著者 Schmitt, A, Berntsson, R.P.A. 登録日 2017-11-02 公開日 2018-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.598 Å) 主引用文献 PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction. Mol. Microbiol., 109, 2018
1S6J	N-terminal Region of the Ca2+-saturated calcium regulatory domain (CLD) from Soybean Calcium-dependent Protein Kinase-alpha (CDPK) 分子名称: CALCIUM ION, Calcium-dependent protein kinase SK5 著者 Weljie, A.M, Vogel, H.J. 登録日 2004-01-23 公開日 2004-12-21 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution Structure and Backbone Dynamics of the N-Terminal Region of the Calcium Regulatory Domain from Soybean Calcium-Dependent Protein Kinase alpha Biochemistry, 42, 2004
2RGU	Crystal structure of complex of human DPP4 and inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, Dipeptidyl peptidase 4 著者 Nar, H, Himmelsbach, F, Eckhardt, M. 登録日 2007-10-05 公開日 2007-11-06 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. J.Med.Chem., 50, 2007
6V8Q	Structure of an inner membrane protein required for PhoPQ regulated increases in outer membrane cardiolipin 分子名称: (9Z,21R,24R,30R,33R,44Z)-24,27,30-trihydroxy-18,24,30,36-tetraoxo-19,23,25,29,31,35-hexaoxa-24lambda~5~,30lambda~5~-dip hosphatripentaconta-9,44-diene-21,33-diyl (9Z,9'Z)di-octadec-9-enoate, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... 著者 Fan, J, Miller, S. 登録日 2019-12-11 公開日 2020-03-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.699585 Å) 主引用文献 Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin. Mbio, 11, 2020
2RJG	Crystal structure of biosynthetic alaine racemase from Escherichia coli 分子名称: Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. 登録日 2007-10-15 公開日 2008-07-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
8EPL	Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution 分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gao, S, Yao, X, Yan, N. 登録日 2022-10-06 公開日 2022-12-14 最終更新日 2023-07-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of the R-type human Ca v 2.3 channel reveal conformational crosstalk of the intracellular segments. Nat Commun, 13, 2022
2BS1	MS2 (N87AE89K mutant) - Qbeta RNA hairpin complex 分子名称: 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *UP*AP*CP*CP*CP*AP*UP*GP*U)-3', MS2 COAT PROTEIN 著者 Horn, W.T, Tars, K, Grahn, E, Helgstrand, C, Baron, A.J, Lago, H, Adams, C.J, Peabody, D.S, Phillips, S.E.V, Stonehouse, N.J, Liljas, L, Stockley, P.G. 登録日 2005-05-13 公開日 2006-03-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis of RNA Binding Discrimination between Bacteriophages Qbeta and MS2. Structure, 14, 2006
6FKA	Crystal structure of N2C/D282C stabilized opsin bound to RS11 分子名称: (2~{S})-2-(3,4-dichlorophenyl)-3-methyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one, PALMITIC ACID, Rhodopsin, ... 著者 Mattle, D, Standfuss, J, Dawson, R. 登録日 2018-01-23 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Ligand channel in pharmacologically stabilized rhodopsin. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8EEB	Cryo-EM structure of human ABCA7 in Digitonin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Phospholipid-transporting ATPase ABCA7, ... 著者 Alam, A, Le, L.T.M, Thompson, J.R. 登録日 2022-09-06 公開日 2022-12-21 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42, 2023
8EKC	Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Rybak, M.Y, Gagnon, M.G. 登録日 2022-09-20 公開日 2022-12-07 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin. Nucleic Acids Res., 51, 2023
6USX	Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer 分子名称: 1-{4-[2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Vigers, G.P, Smith, D.J. 登録日 2019-10-28 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer. J.Med.Chem., 63, 2020
8EE6	Cryo-EM Structure of human ABCA7 in PE/Ch nanodiscs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Phospholipid-transporting ATPase ABCA7, ... 著者 Alam, A, Le, L.T.M, Thompson, J.R. 登録日 2022-09-06 公開日 2022-12-21 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Embo J., 42, 2023

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