PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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7KQ0	PCNA bound to peptide mimetic 分子名称: LYS-ARG-ARG-GLN-THR-SER-MET-THR-ASP-TYR-TYR-HIS-SER-LYS-ARG, Proliferating cell nuclear antigen 著者 Vandborg, B.A, Bruning, J.B. 登録日 2020-11-13 公開日 2021-05-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA. J.Biol.Chem., 296, 2021
7VVY	TRA module of NuA4 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... 著者 Chen, Z, Qu, K. 登録日 2021-11-09 公開日 2022-08-10 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the NuA4 acetyltransferase complex bound to the nucleosome. Nature, 610, 2022
7VXW	Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 1 hour incubation 分子名称: 26S proteasome non-ATPase regulatory subunit 10, UREA 著者 Mukund Sudharsan, M.G, Dalvi, S, Venkatraman, P. 登録日 2021-11-13 公開日 2022-11-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Sci., 31, 2022
7VY7	Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 3 hours incubation 分子名称: 26S proteasome non-ATPase regulatory subunit 10, UREA 著者 Mukund Sudharsan, M.G, Dalvi, S, Venkatraman, P. 登録日 2021-11-13 公開日 2022-11-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Sci., 31, 2022
7VXV	Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 0 hours incubation / Native 分子名称: 26S proteasome non-ATPase regulatory subunit 10 著者 Mukund Sudharsan, M.G, Dalvi, S, Venkatraman, P. 登録日 2021-11-13 公開日 2022-11-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Sci., 31, 2022
6GMN	pVHL:EloB:EloC in complex with methyl 4H-furo[3,2-b]pyrrole-5-carboxylate 分子名称: ACETATE ION, Elongin-B, Elongin-C, ... 著者 Van Molle, I, Lucas, X, Ciulli, A. 登録日 2018-05-27 公開日 2018-08-08 最終更新日 2018-09-05 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61, 2018
7VY4	Snapshots of Human PSMD10(Gankyrin) unfolding by urea: 2 hours incubation 分子名称: 26S proteasome non-ATPase regulatory subunit 10, UREA 著者 Mukund Sudharsan, M.G, Dalvi, S, Venkatraman, P. 登録日 2021-11-13 公開日 2022-11-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Sci., 31, 2022
7JZV	Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome 分子名称: BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ... 著者 Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E. 登録日 2020-09-02 公開日 2021-02-17 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Nat.Struct.Mol.Biol., 28, 2021
6FMK	pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) 分子名称: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... 著者 Soares, P, Lucas, X, Ciulli, A. 登録日 2018-01-31 公開日 2018-04-11 最終更新日 2018-06-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26, 2018
7LYB	Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c 分子名称: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. 登録日 2021-03-06 公開日 2021-07-28 最終更新日 2021-09-01 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
5VTB	Crystal structure of RBBP4 bound to BCL11a peptide 分子名称: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 著者 Meagher, J.L, Stuckey, J.A. 登録日 2017-05-16 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
3KK1	HIV-1 reverse transcriptase-DNA complex with nuceotide inhibitor GS-9148-diphosphate bound in nucleotide site 分子名称: 5'-D(*A*TP*GP*GP*TP*GP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*AP*CP*A*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*(DOC))-3', MAGNESIUM ION, ... 著者 Lansdon, E.B. 登録日 2009-11-04 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J.Mol.Biol., 397, 2010
3KK3	HIV-1 reverse transcriptase-DNA complex with GS-9148 terminated primer 分子名称: 5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*C*(URT))-3', 5'-D(*AP*TP*GP*GP*TP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', MAGNESIUM ION, ... 著者 Lansdon, E.B. 登録日 2009-11-04 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J.Mol.Biol., 397, 2010
5AIR	Structural analysis of mouse GSK3beta fused with LRP6 peptide. 分子名称: Low-density lipoprotein receptor-related protein 6,Glycogen synthase kinase-3 beta, MALONATE ION 著者 Kim, K.L. 登録日 2015-02-17 公開日 2015-04-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Structural Analysis of Mouse Gsk3 Beta Fused with Lrp6 Peptide Biodesign, 3, 2015
4ONJ	Crystal structure of the catalytic domain of ntDRM 分子名称: DNA methyltransferase, SINEFUNGIN 著者 Du, J, Patel, D.J. 登録日 2014-01-28 公開日 2014-06-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.807 Å) 主引用文献 Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell(Cambridge,Mass.), 157, 2014
5LQB	Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody 分子名称: Interleukin-2, anti-hIL2 FAB fragment heavy chain, anti-hIL2 FAB fragment light chain 著者 Zou, C, Wirth, E. 登録日 2016-08-16 公開日 2016-12-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2. Sci Transl Med, 8, 2016
8KHP	CULLIN3-KLHL22-RBX1 E3 ligase 分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22 著者 Su, M.-Y, Su, M.-Y. 登録日 2023-08-22 公開日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure, 31, 2023
8K9I	Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif 分子名称: Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... 著者 Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. 登録日 2023-08-01 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
6FCM	Crystal structure of human PCNA 分子名称: Proliferating cell nuclear antigen 著者 Housset, D, Frachet, P. 登録日 2017-12-20 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. J.Exp.Med., 216, 2019
6FCN	Crystal structure of human PCNA soaked with p47phox(106-127) peptide 分子名称: Proliferating cell nuclear antigen 著者 Housset, D, Frachet, P. 登録日 2017-12-20 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. J.Exp.Med., 216, 2019
7T91	Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region 分子名称: Isoform 2 of Zinc finger protein GLI1, ZINC ION 著者 Wu, M, Zhang, S, Augelli-Szanfran, C.E, Boohaker, R.J. 登録日 2021-12-17 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region To Be Published
4B6F	Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function 分子名称: (4-phenoxyphenyl)methylazanium, NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3, ... 著者 Saalau-Bethell, S.M, Woodhead, A.J, Chessari, G, Carr, M.G, Coyle, J, Graham, B, Hiscock, S.D, Murray, C.W, Pathuri, P, Rich, S.J, Richardson, C.J, Williams, P.A, Jhoti, H. 登録日 2012-08-09 公開日 2012-10-03 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Discovery of an Allosteric Mechanism for the Regulation of Hcv Ns3 Protein Function. Nat.Chem.Biol., 8, 2012
7U9Y	WDR5 bound to 2-(3,5-dimethoxybenzyl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one 分子名称: (5P)-2-[(3,5-dimethoxyphenyl)methyl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-1(2H)-one, BENZAMIDINE, WD repeat-containing protein 5 著者 Rietz, T. 登録日 2022-03-11 公開日 2022-04-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
3DPR	Human rhinovirus 2 bound to a concatamer of the VLDL receptor module V3 分子名称: CALCIUM ION, LAURIC ACID, LDL-receptor class A 3, ... 著者 Querol-Audi, J, Pous, J, Fita, I, Verdaguer, N. 登録日 2008-07-09 公開日 2009-04-07 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Minor group human rhinovirus-receptor interactions: geometry of multimodular attachment and basis of recognition Febs Lett., 583, 2009
7T36	Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322 分子名称: (3R)-4-[6-{1-[diamino(hydroxy)-lambda~4~-sulfanyl]cyclopropyl}-2-(methylsulfanyl)pyrimidin-4-yl]-3-methylmorpholine, 1,2-ETHANEDIOL, Transcription initiation factor TFIID subunit 1 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-12-07 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322 To Be Published

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