4B6F

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Summary for 4B6F

• Entry DOI: 10.2210/pdb4b6f/pdb
• Related: 1A1Q 1BT7 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2I1R 2JC0 2JC1 2WCX 2WHO 2XWY 4A92 4B6E 8OHM
• Descriptor: NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3, SULFATE ION, (4-phenoxyphenyl)methylazanium, ... (4 entities in total)
• Functional Keywords: hydrolase, helicase-protease, allosteric pocket, fusion protein
• Biological source: HEPATITIS C VIRUS (ISOLATE BK)
• Total number of polymer chains: 2
• Total formula weight: 145525.25

Authors

Saalau-Bethell, S.M.,Woodhead, A.J.,Chessari, G.,Carr, M.G.,Coyle, J.,Graham, B.,Hiscock, S.D.,Murray, C.W.,Pathuri, P.,Rich, S.J.,Richardson, C.J.,Williams, P.A.,Jhoti, H. (deposition date: 2012-08-09, release date: 2012-10-03, Last modification date: 2023-12-20)

• Primary citation: Saalau-Bethell, S.M.,Woodhead, A.J.,Chessari, G.,Carr, M.G.,Coyle, J.,Graham, B.,Hiscock, S.D.,Murray, C.W.,Pathuri, P.,Rich, S.J.,Richardson, C.J.,Williams, P.A.,Jhoti, H.; Discovery of an Allosteric Mechanism for the Regulation of Hcv Ns3 Protein Function.; Nat.Chem.Biol., 8:920-, 2012; PubMed: 23023261; DOI: 10.1038/NCHEMBIO.1081

Experimental method

X-RAY DIFFRACTION (2.89 Å)