2BRL
Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 2)
Summary for 2BRL
Entry DOI | 10.2210/pdb2brl/pdb |
Related | 1A1Q 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NS3 1QUV 2BRK 8OHM |
Descriptor | RNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 3-CYCLOHEXYL-1-(2-{METHYL[(1-METHYLPIPERIDIN-3-YL)METHYL]AMINO}-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | transferase, hepatitis c virus, hcv, ns5b, polymerase, rna-dependent rna- polymerase, allosteric inhibitor, nucleotidyltransferase |
Biological source | HEPATITIS C VIRUS (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
Total number of polymer chains | 1 |
Total formula weight | 60253.04 |
Authors | Di Marco, S.,Volpari, C.,Carfi, A. (deposition date: 2005-05-06, release date: 2005-06-14, Last modification date: 2023-12-13) |
Primary citation | Di Marco, S.,Volpari, C.,Tomei, L.,Altamura, S.,Harper, S.,Narjes, F.,Koch, U.,Rowley, M.,De Francesco, R.,Migliaccio, G.,Carfi, A. Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280:29765-, 2005 Cited by PubMed: 15955819DOI: 10.1074/JBC.M505423200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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