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2BRK

Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1)

Summary for 2BRK
Entry DOI10.2210/pdb2brk/pdb
Related1A1Q 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NS3 1QUV 2BRL 8OHM
DescriptorRNA-DIRECTED RNA POLYMERASE, MANGANESE (II) ION, 3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, ... (4 entities in total)
Functional Keywordstransferase, hepatitis c virus, hcv, ns5b, polymerase, rna-dependent rna- polymerase, allosteric inhibitor, atp-binding
Biological sourceHEPATITIS C VIRUS
Cellular locationCore protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
Total number of polymer chains1
Total formula weight60197.92
Authors
Di Marco, S.,Volpari, C.,Carfi, A. (deposition date: 2005-05-06, release date: 2005-06-14, Last modification date: 2023-12-13)
Primary citationDi Marco, S.,Volpari, C.,Tomei, L.,Altamura, S.,Harper, S.,Narjes, F.,Koch, U.,Rowley, M.,De Francesco, R.,Migliaccio, G.,Carfi, A.
Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site
J.Biol.Chem., 280:29765-, 2005
Cited by
PubMed: 15955819
DOI: 10.1074/JBC.M505423200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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