2BRK

Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A1532

Chain	Residue
A	ASP220
A	THR221
A	ASP318
A	MN1533
A	HOH2442
A	HOH2443

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A1533

Chain	Residue
A	MN1532
A	HOH2444
A	ASP220
A	ASP318
A	ASP319

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CMF A1534

Chain	Residue
A	VAL37
A	LEU392
A	ALA396
A	HIS428
A	GLY493
A	PRO495
A	ARG503
A	HOH2425

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572

Chain	Residue	Details
A	ASP220
A	ASP318
A	ASP319

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662

Chain	Residue	Details
A	SER29
A	SER42

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