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2BRK

Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
RNA-DIRECTED RNA POLYMERASEpolymer53659641.51UniProt (P26663)
Pfam (PF00998)
HEPATITIS C VIRUSHEPATITIS C VIRUS POLYMERASE, P68, NS5B
2B, C
(A)
MANGANESE (II) IONnon-polymer54.92Chemie (MN)
3D
(A)
3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACIDnon-polymer446.51Chemie (CMF)
4E
(A)
waterwater18.0445Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight59641.5
Non-Polymers*Number of molecules3
Total formula weight556.4
All*Total formula weight60197.9
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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