PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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5TC5	Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-DADMe-Immucillin-A and chloride 分子名称: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, S-methyl-5'-thioadenosine phosphorylase 著者 Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C. 登録日 2016-09-14 公開日 2017-10-11 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 TBA To be published
2CAR	Crystal Structure Of Human Inosine Triphosphatase 分子名称: INOSINE TRIPHOSPHATE PYROPHOSPHATASE 著者 Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Hogbom, M, Holmberg Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Nordlund, P. 登録日 2005-12-22 公開日 2006-01-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.09 Å) 主引用文献 Crystal Structure of Human Inosine Triphosphatase. Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T. J.Biol.Chem., 282, 2007
5U9G	3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Demo, G, Svidritskiy, E, Madireddy, R, Diaz-Avalos, R, Grant, T, Grigorieff, N, Sousa, D, Korostelev, A.A. 登録日 2016-12-16 公開日 2017-03-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanism of ribosome rescue by ArfA and RF2. Elife, 6, 2017
5U9F	3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Demo, G, Svidritskiy, E, Madireddy, R, Diaz-Avalos, R, Grant, T, Grigorieff, N, Sousa, D, Korostelev, A.A. 登録日 2016-12-16 公開日 2017-03-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanism of ribosome rescue by ArfA and RF2. Elife, 6, 2017
5UDX	LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, in complex with zinc 分子名称: Lactate racemization operon protein LarE, PHOSPHATE ION, SULFATE ION, ... 著者 Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. 登録日 2016-12-28 公開日 2017-08-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.784 Å) 主引用文献 Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6ET9	Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ... 著者 Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T. 登録日 2017-10-25 公開日 2018-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7R4X	Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Pellegrino, S, Dent, K.C, Spikes, T, Warren, A.J. 登録日 2022-02-09 公開日 2023-02-22 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.15 Å) 主引用文献 Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution. Nucleic Acids Res., 51, 2023
5YCB	Crystal structure of notothenia coriiceps adenylate kinase variant 分子名称: BIS(ADENOSINE)-5'-PENTAPHOSPHATE, SULFATE ION, adenylate kinase 著者 Bae, E, Kim, J, Moon, S. 登録日 2017-09-07 公開日 2018-09-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.272 Å) 主引用文献 Crystal structure of notothenia coriiceps adenylate kinase variant To Be Published
5DRB	Crystal structure of WNK1 in complex with WNK463 分子名称: N-tert-butyl-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl}piperidin-4-yl)-1H-imidazole-5-carboxamide, Serine/threonine-protein kinase WNK1 著者 Kohls, D, Xie, X. 登録日 2015-09-15 公開日 2016-09-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat.Chem.Biol., 12, 2016
7RTD	SARS-CoV-2 Spike-derived peptide S269-277 (YLQPRTFLL) presented by HLA-A*02:01 分子名称: Beta-2-microglobulin, HLA class I antigen, Spike protein S1 著者 Szeto, C, Nguyen, A.T, Gras, S. 登録日 2021-08-13 公開日 2021-10-13 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR. Cells, 10, 2021
7RTS	Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 without the AE interface 分子名称: Disease resistance protein RUN1, SULFATE ION 著者 Burdett, H, Kobe, B. 登録日 2021-08-15 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Self-association configures the NAD + -binding site of plant NLR TIR domains Biorxiv, 2021
7RX1	Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 分子名称: Disease resistance protein RUN1, SULFATE ION 著者 Burdett, H, Kobe, B. 登録日 2021-08-21 公開日 2021-10-13 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Self-association configures the NAD + -binding site of plant NLR TIR domains Biorxiv, 2021
7ROY	The structure of the Fem1B:FNIP1 complex 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Folliculin-interacting protein 1, Protein fem-1 homolog B, ... 著者 Gee, C.L, Mena, E.L, Manford, A.G, Rape, M. 登録日 2021-08-02 公開日 2021-10-13 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis and regulation of the reductive stress response. Cell, 184, 2021
9MU6	Structure of native Drosophila melanogaster DLST 分子名称: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 著者 Venette-Smith, N.L, Vishwakarma, R.K, Dollinger, R, Schultz, J, Venkatakrishnan, V, Babitzke, P, Anand, G, Gilmour, D.S, Armache, J.-P, Murakami, K. 登録日 2025-01-13 公開日 2025-02-19 実験手法 ELECTRON MICROSCOPY (3.66 Å) 主引用文献 Structural Characterization of Native RNA Polymerase II Transcription Complexes in Drosophila melanogaster To Be Published
7RTR	YLQ-SG3 TCR in complex with SARS-CoV-2 Spike-derived peptide S269-277 (YLQPRTFLL) presented by HLA-A*02:01 分子名称: Beta-2-microglobulin, HLA class I antigen, SODIUM ION, ... 著者 Szeto, C, Gras, S. 登録日 2021-08-14 公開日 2021-10-13 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR. Cells, 10, 2021
5YCD	Crystal structure of Poecilia reticulata adenylate kinase 分子名称: Adenylayte kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION 著者 Bae, E, Kim, J, Moon, S. 登録日 2017-09-07 公開日 2018-09-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Poecilia reticulata adenylate kinase To Be Published
7S2Z	Crystal structure of the E100A mutant TIR domain from the grapevine disease resistance protein RUN1 bound to NAD 分子名称: Disease resistance protein RUN1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Burdett, H, Kobe, B. 登録日 2021-09-04 公開日 2021-10-13 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Self-association configures the NAD + -binding site of plant NLR TIR domains Biorxiv, 2021
5DO7	Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8 分子名称: ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8 著者 Lee, J.-Y, Kinch, L.N, Borek, D.M, Urbatsch, I.L, Xie, X.-S, Grishin, N.V, Cohen, J.C, Otwinowski, Z, Hobbs, H.H, Rosenbaum, D.M. 登録日 2015-09-10 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.93 Å) 主引用文献 Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature, 533, 2016
9MGN	Crystal structure of PRMT5:MEP50 in complex with MTA and compound 41 分子名称: 1,2-ETHANEDIOL, 2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-{6-[(1H-pyrazol-4-yl)methoxy]-3,4-dihydroisoquinolin-2(1H)-yl}propyl]pyridine-4-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... 著者 Whittington, D.A. 登録日 2024-12-11 公開日 2025-03-05 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design. J.Med.Chem., 68, 2025
9MGQ	Crystal structure of PRMT5:MEP50 in complex with sinefungin and compound 47 分子名称: 1,2-ETHANEDIOL, 2-(cyclobutylamino)-N-{(2R)-2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]ethyl}pyridine-4-carboxamide, DI(HYDROXYETHYL)ETHER, ... 著者 Whittington, D.A. 登録日 2024-12-11 公開日 2025-03-05 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design. J.Med.Chem., 68, 2025
9MGR	Crystal structure of PRMT5:MEP50 in complex with MTA and compound 51 分子名称: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, 6-[(1-acetylazetidin-3-yl)amino]-N-[(2R)-2-hydroxy-2-{(3S)-7-[(4-methyl-1,3-oxazol-5-yl)methoxy]-1,2,3,4-tetrahydroisoquinolin-3-yl}ethyl]-2-(4-methylpiperidin-1-yl)pyrimidine-4-carboxamide, ... 著者 Whittington, D.A. 登録日 2024-12-11 公開日 2025-03-05 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design. J.Med.Chem., 68, 2025
5YCC	Crystal structure of Notothenia coriiceps adenylate kinase variant 分子名称: BIS(ADENOSINE)-5'-PENTAPHOSPHATE, SULFATE ION, adenylate kinase 著者 Bae, E, Kim, J, Moon, S. 登録日 2017-09-07 公開日 2018-09-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of Notothenia coriiceps adenylate kinase variant To Be Published
9MRE	From DNA-Encoded Library Screening to AM-9747 - an MTA-Cooperative PRMT5 Inhibitor with Potent Oral in vivo Efficacy 分子名称: 2-amino-3-methyl-N-[(1R)-1-(pyrimidin-2-yl)ethyl]-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}quinoline-6-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... 著者 GhimireRijal, S, Mukund, S. 登録日 2025-01-07 公開日 2025-03-26 最終更新日 2025-04-02 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 From DNA-Encoded Library Screening to AM-9747 : An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy. J.Med.Chem., 68, 2025
7RR5	Structure of ribosomal complex bound with Rbg1/Tma46 分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S0, ... 著者 Zeng, F, Li, X, Pires-Alves, M, Chen, X, Hawk, C.W, Jin, H. 登録日 2021-08-09 公開日 2021-11-10 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Cell Rep, 37, 2021
7ROQ	Alternative Structure of Human ABCA1 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Aller, S.G. 登録日 2021-08-01 公開日 2022-01-19 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Refined ABCA1 with Domain-swapped Regulatory Domains Plos One, 2022

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