6GZS
| |
6GZ3
| tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | 登録日 | 2018-07-03 | 公開日 | 2018-12-05 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Rep, 25, 2018
|
|
6A6I
| Crystal structure of the winged-helix domain of Cockayne syndrome group B protein in complex with ubiquitin | 分子名称: | CHLORIDE ION, Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant, ... | 著者 | Takahashi, T.S, Sato, Y, Fukai, S. | 登録日 | 2018-06-28 | 公開日 | 2019-02-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein. Nucleic Acids Res., 47, 2019
|
|
6A42
| R1EN(5-223)-ubiquitin fusion | 分子名称: | ACETIC ACID, RNA-directed DNA polymerase homolog (R1),Polyubiquitin-C | 著者 | Maita, N. | 登録日 | 2018-06-19 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure Determination of Ubiquitin by Fusion to a Protein That Forms a Highly Porous Crystal Lattice J. Am. Chem. Soc., 140, 2018
|
|
6A43
| R1EN(5-225)-ubiquitin fusion | 分子名称: | ACETIC ACID, RNA-directed DNA polymerase homolog (R1),Polyubiquitin-C | 著者 | Maita, N. | 登録日 | 2018-06-19 | 公開日 | 2018-10-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure Determination of Ubiquitin by Fusion to a Protein That Forms a Highly Porous Crystal Lattice J. Am. Chem. Soc., 140, 2018
|
|
6A44
| R1EN(5-227)-ubiquitin fusion | 分子名称: | ACETIC ACID, RNA-directed DNA polymerase homolog (R1),Polyubiquitin-C | 著者 | Maita, N. | 登録日 | 2018-06-19 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure Determination of Ubiquitin by Fusion to a Protein That Forms a Highly Porous Crystal Lattice J. Am. Chem. Soc., 140, 2018
|
|
6GMQ
| pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol | 分子名称: | (4-pyrrol-1-ylphenyl)methanol, ACETATE ION, Elongin-B, ... | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | 登録日 | 2018-05-28 | 公開日 | 2018-08-22 | 最終更新日 | 2018-09-05 | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61, 2018
|
|
6GMR
| pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol | 分子名称: | (4-pyrrol-1-ylphenyl)methanol, Elongin-B, Elongin-C, ... | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | 登録日 | 2018-05-28 | 公開日 | 2018-08-08 | 最終更新日 | 2018-09-05 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61, 2018
|
|
6GMX
| pVHL:EloB:EloC in complex with 6-chlorothiochroman-4-one | 分子名称: | 6-chloranyl-2,3-dihydrothiochromen-4-one, ACETATE ION, Elongin-B, ... | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | 登録日 | 2018-05-28 | 公開日 | 2018-08-08 | 最終更新日 | 2018-09-05 | 実験手法 | X-RAY DIFFRACTION (2.533 Å) | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61, 2018
|
|
6GMN
| pVHL:EloB:EloC in complex with methyl 4H-furo[3,2-b]pyrrole-5-carboxylate | 分子名称: | ACETATE ION, Elongin-B, Elongin-C, ... | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | 登録日 | 2018-05-27 | 公開日 | 2018-08-08 | 最終更新日 | 2018-09-05 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61, 2018
|
|
6DJX
| Crystal Structure of pParkin-pUb-UbcH7 complex | 分子名称: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | 著者 | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | 登録日 | 2018-05-27 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (4.801 Å) | 主引用文献 | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
|
|
6DJW
| Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex | 分子名称: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | 著者 | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | 登録日 | 2018-05-26 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.801 Å) | 主引用文献 | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
|
|
6GLC
| Structure of phospho-Parkin bound to phospho-ubiquitin | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | 著者 | Gladkova, C, Maslen, S.L, Skehel, J.M, Komander, D. | 登録日 | 2018-05-23 | 公開日 | 2018-06-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of parkin activation by PINK1. Nature, 559, 2018
|
|
6DGF
| Ubiquitin Variant bound to USP2 | 分子名称: | Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 2, ... | 著者 | Manczyk, N, Sicheri, F. | 登録日 | 2018-05-17 | 公開日 | 2019-02-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases. J. Mol. Biol., 431, 2019
|
|
6DC6
| Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin | 分子名称: | MAGNESIUM ION, PYROPHOSPHATE 2-, Ubiquitin, ... | 著者 | Lv, Z, Yuan, L, Williams, K.M, Atkison, J.H, Olsen, S.K. | 登録日 | 2018-05-04 | 公開日 | 2018-10-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | 主引用文献 | Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity. J. Biol. Chem., 293, 2018
|
|
6GFY
| pVHL:EloB:EloC in complex with modified VH032 containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 14a) | 分子名称: | (2~{R},3~{R},4~{S})-1-[(2~{S})-2-acetamido-3,3-dimethyl-butanoyl]-3-fluoranyl-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Gadd, M.S, Testa, A, Ciulli, A. | 登録日 | 2018-05-02 | 公開日 | 2018-07-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140, 2018
|
|
6GFX
| pVHL:EloB:EloC in complex with modified HIF-1a CODD peptide containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 13a) | 分子名称: | Elongin-B, Elongin-C, FLUORINATED HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PEPTIDE, ... | 著者 | Castro, G.V, Testa, A, Ciulli, A. | 登録日 | 2018-05-02 | 公開日 | 2018-07-11 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140, 2018
|
|
6GFZ
| pVHL:EloB:EloC in complex with modified VH032 containing (3S,4S)-3-fluoro-4-hydroxyproline (ligand 14b) | 分子名称: | (2~{R},3~{S},4~{S})-1-[(2~{S})-2-acetamido-3,3-dimethyl-butanoyl]-3-fluoranyl-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Gadd, M.S, Testa, A, Ciulli, A. | 登録日 | 2018-05-02 | 公開日 | 2018-07-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140, 2018
|
|
6D9J
| Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1. | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | 著者 | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | 登録日 | 2018-04-30 | 公開日 | 2018-06-06 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
|
|
6GF2
| The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome | 分子名称: | Ubiquitin D | 著者 | Aichem, A, Anders, S, Catone, N, Roessler, P, Stotz, S, Berg, A, Schwab, R, Scheuermann, S, Bialas, J, Schmidtke, G, Peter, C, Groettrup, M, Wiesner, S. | 登録日 | 2018-04-29 | 公開日 | 2018-08-08 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat Commun, 9, 2018
|
|
6GF1
| The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome | 分子名称: | SULFATE ION, Ubiquitin D | 著者 | Aichem, A, Anders, S, Catone, N, Roessler, P, Stotz, S, Berg, A, Schwab, R, Scheuermann, S, Bialas, J, Schmidtke, G, Peter, C, Groettrup, M, Wiesner, S. | 登録日 | 2018-04-28 | 公開日 | 2018-08-29 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.925 Å) | 主引用文献 | The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat Commun, 9, 2018
|
|
6D90
| Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | 著者 | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | 登録日 | 2018-04-27 | 公開日 | 2018-06-06 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
|
|
6D6I
| Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13 | 分子名称: | Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1, Ubv.V1.1 | 著者 | Ceccarelli, D.F, Garg, P, Keszei, A, Sidhu, S, Sicheri, F. | 登録日 | 2018-04-21 | 公開日 | 2019-07-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | 主引用文献 | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
|
|
6D68
| Ube2G1 in complex with ubiquitin variant Ubv.G1.1 | 分子名称: | Ubiquitin-conjugating enzyme E2 G1, Ubv.G1.1 | 著者 | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | 登録日 | 2018-04-20 | 公開日 | 2019-07-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
|
|
6D4P
| Ube2D1 in complex with ubiquitin variant Ubv.D1.1 | 分子名称: | Ubiquitin Variant Ubv.D1.1, Ubiquitin-conjugating enzyme E2 D1 | 著者 | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | 登録日 | 2018-04-18 | 公開日 | 2019-07-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
|
|