PDB: 82203 件ウェブページステータス検索Chemie searchBIRD

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9AVG	Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs 分子名称: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-03-02 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
3IEU	Crystal Structure of ERA in Complex with GDP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GTP-binding protein era, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tu, C, Ji, X. 登録日 2009-07-23 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis Proc.Natl.Acad.Sci.USA, 106, 2009
9ASB	Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs 分子名称: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-02-24 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
9AVL	Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs 分子名称: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-03-04 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
8WFT	Crystal structure of beta-glucosidase from Thermoanaerobacterium saccharolyticum (Data 1) 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucosidase, ... 著者 Nam, K.H. 登録日 2023-09-20 公開日 2023-10-04 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Conformational Change of the L3 Loop Affects the Structural Changes in the Substrate Binding Pocket Entrance of beta-Glucosidase. Molecules, 28, 2023
3ILI	Crystal structure of E. coli HPPK(D95A) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-08-07 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and functional roles of residues D95 and D97 in E. coli HPPK To be Published
6ZZ3	RBcel1 cellulase variant Y201F with cellotriose covalently bound 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endoglucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Collet, L, Dutoit, R. 登録日 2020-08-03 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Glycoside hydrolase family 5: structural snapshots highlighting the involvement of two conserved residues in catalysis. Acta Crystallogr D Struct Biol, 77, 2021
7ACO	Crystal structure of E. coli HTH-type transcriptional regulator RcdA in complex with Tris at 1.80 A resolution 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HTH-type transcriptional regulator RcdA 著者 Pietrzyk-Brzezinska, A.J, Cociurovscaia, A. 登録日 2020-09-11 公開日 2021-08-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Structures of the TetR-like transcription regulator RcdA alone and in complexes with ligands. Proteins, 90, 2022
3IS6	The Crystal Structure of a domain of a putative Permease protein from Porphyromonas gingivalis to 2A 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, putative permease protein, ... 著者 Stein, A.J, Sather, A, Duggan, E, Moy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-08-25 公開日 2009-09-08 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Crystal Structure of a domain of a putative Permease protein from Porphyromonas gingivalis to 2A To be Published
3IHB	Crystal Structure Analysis of Mglu in its tris and glutamate form 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLUTAMIC ACID, Salt-tolerant glutaminase 著者 Yoshimune, K, Shirakihara, Y. 登録日 2009-07-29 公開日 2010-01-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product l-glutamate and its activator Tris Febs J., 277, 2010
7L35	Human DNA Ligase 1 - R771W nicked DNA complex 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Tumbale, P.P, Williams, R.S, Schellenberg, M.S. 登録日 2020-12-17 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. Nucleic Acids Res., 49, 2021
4GYO	Crystal Structure of Rap Protein Complexed with Competence and Sporulation Factor 分子名称: CHLORIDE ION, CSF peptide, Response regulator aspartate phosphatase J 著者 Parashar, V, Neiditch, M.B. 登録日 2012-09-05 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Conformational change-induced repeat domain expansion regulates rap phosphatase quorum-sensing signal receptors. Plos Biol., 11, 2013
3ISM	Crystal structure of the EndoG/EndoGI complex: Mechanism of EndoG inhibition 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CG4930, CG8862, ... 著者 Loll, B, Gebhardt, M, Wahle, E, Meinhart, A. 登録日 2009-08-26 公開日 2009-09-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. Nucleic Acids Res., 37, 2009
3IWF	The Crystal Structure of the N-terminal domain of a RpiR Transcriptional Regulator from Staphylococcus epidermidis to 1.4A 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-METHOXYETHANOL, CHLORIDE ION, ... 著者 Stein, A.J, Sather, A, Borovilos, M, Bargassa, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-09-02 公開日 2009-09-15 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The Crystal Structure of the N-terminal domain of a RpiR Transcriptional Regulator from Staphylococcus epidermidis to 1.4A To be Published
7KQT	A 1.84-A resolution crystal structure of heme-dependent L-tyrosine hydroxylase in complex with 3-fluoro-L-tyrosine and cyanide 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-FLUOROTYROSINE, CYANIDE ION, ... 著者 Wang, Y, Liu, A. 登録日 2020-11-17 公開日 2021-03-31 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.835 Å) 主引用文献 Molecular Rationale for Partitioning between C-H and C-F Bond Activation in Heme-Dependent Tyrosine Hydroxylase. J.Am.Chem.Soc., 143, 2021
3KJ0	Mcl-1 in complex with Bim BH3 mutant I2dY 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 著者 Fire, E, Grant, R.A, Keating, A.E. 登録日 2009-11-02 公開日 2010-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
7KJ6	Structure of Legionella Effector LegA15 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Ankyrin repeat-containing protein, CHLORIDE ION, ... 著者 Cygler, M, Chung, I.Y.W. 登録日 2020-10-26 公開日 2021-08-18 最終更新日 2021-12-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Legionella effector LegA15/AnkH contains an unrecognized cysteine protease-like domain and displays structural similarity to LegA3/AnkD, but differs in host cell localization. Acta Crystallogr D Struct Biol, 77, 2021
7KGC	Crystal structure of a perchloric acid-soluble protein (PSP) from Trichomonas vaginalis at 1.95 A 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Putative translation initiation inhibitor 著者 Diaz-Vilchis, A, Rudino-Pinera, E, Alvarez-Sanchez, M.E, Arreola, R. 登録日 2020-10-16 公開日 2021-10-20 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A Putative New Role of Tv-PSP1 Recognizes IRE and ERE Hairpin Structures from Trichomonas vaginalis. Pathogens, 12, 2023
5FSN	MTH1 substrate recognition: Complex with a aminomethylpyrimidinyl oxypropanol. 分子名称: 3-(2-AMINO-6-METHYL-PYRIMIDIN-4-YL)OXYPROPAN-1-OL, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, ... 著者 Nissink, J.W.M, Bista, M, Breed, J, Carter, N, Embrey, K, Read, J, Phillips, C, Winter, J.J. 登録日 2016-01-06 公開日 2016-07-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Mth1 Substrate Recognition--an Example of Specific Promiscuity. Plos One, 11, 2016
1CA0	BOVINE CHYMOTRYPSIN COMPLEXED TO APPI 分子名称: BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR 著者 Scheidig, A.J, Kossiakoff, A.A. 登録日 1997-01-23 公開日 1997-07-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
2BME	high resolution structure of GppNHp-bound human Rab4a 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... 著者 Scheidig, A.J, Huber, S.K. 登録日 2005-03-13 公開日 2005-04-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 High Resolution Crystal Structures of Human Rab4A in its Active and Inactive Conformations. FEBS Lett., 579, 2005
2BML	Ofloxacin-like antibiotics inhibit pneumococcal cell wall degrading virulence factors 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AUTOLYSIN, DEXTROFLOXACINE, ... 著者 Fernandez-Tornero, C, Gimenez-Gallego, G, Romero, A, Garcia, E, Pascual-Teresa, B.D, Lopez, R. 登録日 2005-03-15 公開日 2005-03-30 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall-Degrading Virulence Factors J.Biol.Chem., 280, 2005
5UGB	Crystal structure of the EGFR kinase domain in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium 分子名称: 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium, Epidermal growth factor receptor 著者 Gajiwala, K.S, Ferre, R.A. 登録日 2017-01-07 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR. J. Med. Chem., 60, 2017
7L74	Crystal structure of Beta-hexosyl transferase from Hamamotoa (Sporobolomyces) singularis bound to TRIS 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-hexosyltransferase, ... 著者 Dagher, S.F, Edwards, B.F.P, Meilleur, F, Bruno-Barcena, J.M. 登録日 2020-12-25 公開日 2022-02-09 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure and mutagenic analysis of the Beta-hexosyltransferase from Hamamotoa (Sporobolomyces) singularis To Be Published
3KHS	Crystal structure of grouper iridovirus purine nucleoside phosphorylase 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Purine nucleoside phosphorylase 著者 Kang, Y.N, Zhang, Y, Allan, P.W, Parker, W.B, Ting, J.W, Chang, C.Y, Ealick, S.E. 登録日 2009-10-30 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Structure of grouper iridovirus purine nucleoside phosphorylase Acta Crystallogr.,Sect.D, 66, 2010

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