2E5H
 
 | | Solution structure of RNA binding domain in Zinc finger CCHC-type and RNA binding motif 1 | | 分子名称: | Zinc finger CCHC-type and RNA-binding motif-containing protein 1 | | 著者 | Iibuchi, H, Tsuda, K, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-12-21 | | 公開日 | 2007-06-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of RNA binding domain in Zinc finger CCHC-type and RNA binding motif 1
To be Published
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7L1G
 | | PRMT5-MEP50 Complexed with SAM | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Methylosome protein 50, ... | | 著者 | Palte, R.L. | | 登録日 | 2020-12-14 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4- b ]furan Nucleoside Analogues.
J.Org.Chem., 86, 2021
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7KID
 | | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | | 分子名称: | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | | 著者 | Palte, R.L. | | 登録日 | 2020-10-23 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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7KIC
 | | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | | 著者 | Palte, R.L. | | 登録日 | 2020-10-23 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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7KIB
 | | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 | | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Palte, R.L, Hayes, R.P. | | 登録日 | 2020-10-23 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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7LUV
 | | Cryo-EM structure of the yeast THO-Sub2 complex | | 分子名称: | ATP-dependent RNA helicase SUB2, THO complex subunit 2, THO complex subunit HPR1, ... | | 著者 | Xie, Y, Ren, Y. | | 登録日 | 2021-02-23 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2.
Elife, 10, 2021
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3TP2
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3GIX
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6CKC
 | | Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity | | 分子名称: | 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | 著者 | Antonysamy, S. | | 登録日 | 2018-02-27 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
ACS Med Chem Lett, 9, 2018
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2MY1
 | | Solution structure of Bud31p | | 分子名称: | Pre-mRNA-splicing factor BUD31, ZINC ION | | 著者 | van Roon, A.M, Yang, J, Mathieu, D, Bermel, W, Nagai, K, Neuhaus, D. | | 登録日 | 2015-01-19 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | (113) Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4R0D
 | | Crystal structure of a eukaryotic group II intron lariat | | 分子名称: | GROUP IIB INTRON LARIAT, IRIDIUM HEXAMMINE ION, LIGATED EXONS, ... | | 著者 | Robart, A.R, Chan, R.T, Peters, J.K, Rajashankar, K.R, Toor, N. | | 登録日 | 2014-07-30 | | 公開日 | 2014-10-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.676 Å) | | 主引用文献 | Crystal structure of a eukaryotic group II intron lariat.
Nature, 514, 2014
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6G70
 | | Structure of murine Prpf39 | | 分子名称: | Pre-mRNA-processing factor 39 | | 著者 | De Bortoli, F.D, Loll, B, Wahl, M, Heyd, F. | | 登録日 | 2018-04-04 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.
Nucleic Acids Res., 47, 2019
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6K1S
 | | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, DIMETHYL SULFOXIDE, ... | | 著者 | Tong, S, Lin, H. | | 登録日 | 2019-05-12 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Acs Med.Chem.Lett., 10, 2019
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2O32
 | | Solution structure of U2 snRNA stem I from human, containing modified nucleotides | | 分子名称: | 5'-R(*(PSU)P*CP*UP*CP*(OMG)P*(OMG)P*CP*CP*(PSU)P*UP*UP*UP*(OMG)P*GP*CP*UP*AP*AP*(OMG)P*A)-3' | | 著者 | Sashital, D.G, Venditti, V, Angers, C.G, Cornilescu, G, Butcher, S.E. | | 登録日 | 2006-11-30 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and thermodynamics of a conserved U2 snRNA domain from yeast and human.
Rna, 13, 2007
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6Q8F
 | | Nterminal domain of human SMU1 | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, WD40 repeat-containing protein SMU1 | | 著者 | Tengo, L, Le Corre, L, Fournier, G, Ashraf, U, Busca, P, Rameix-Welti, M.-A, Gravier-Pelletier, C, Ruigrok, R.W.H, Jacob, Y, Vidalain, P.-O, Pietrancosta, N, Naffakh, N, McCarthy, A.A, Crepin, T. | | 登録日 | 2018-12-14 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116, 2019
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1RK8
 | | Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex | | 分子名称: | CALCIUM ION, CG8781-PA protein, Mago nashi protein, ... | | 著者 | Bono, F, Ebert, J, Guettler, T, Izaurralde, E, Conti, E. | | 登録日 | 2003-11-21 | | 公開日 | 2004-04-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular insights into the interaction of PYM with
the Mago-Y14 core of the exon junction complex
EMBO Rep., 5, 2004
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2O33
 | | Solution structure of U2 snRNA stem I from S. cerevisiae | | 分子名称: | U2 snRNA | | 著者 | Sashital, D.G, Venditti, V, Angers, C.A, Cornilescu, G, Butcher, S.E. | | 登録日 | 2006-11-30 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and thermodynamics of a conserved U2 snRNA domain from yeast and human.
Rna, 13, 2007
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5I8Q
 | | S. cerevisiae Prp43 in complex with RNA and ADPNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, ... | | 著者 | He, Y, Nielsen, K.H, Andersen, G.R. | | 登録日 | 2016-02-19 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.
RNA, 23, 2017
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5JPT
 | | CRYSTAL STRUCTURE OF THE PRP43P DEAH-BOX RNA HELICASE IN COMPLEX WITH CDP | | 分子名称: | ACETATE ION, CYTIDINE-5'-DIPHOSPHATE, GLYCEROL, ... | | 著者 | Robert-Paganin, J, Rety, S, Leulliot, N. | | 登録日 | 2016-05-04 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.935 Å) | | 主引用文献 | Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding.
Nucleic Acids Res., 45, 2017
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4HM9
 | | Crystal structure of full-length human catenin-beta-like 1 | | 分子名称: | Beta-catenin-like protein 1 | | 著者 | Du, Z, Huang, X, Wang, G, Wu, Y. | | 登録日 | 2012-10-18 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.1001 Å) | | 主引用文献 | The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family.
Acta Crystallogr.,Sect.D, 69, 2013
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4IN0
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4GQB
 | | Crystal Structure of the human PRMT5:MEP50 Complex | | 分子名称: | (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid, Histone H4 peptide, Methylosome protein 50, ... | | 著者 | Antonysamy, S, Bonday, Z, Campbell, R, Doyle, B, Druzina, Z, Gheyi, T, Han, B, Jungheim, L.N, Qian, Y, Rauch, C, Russell, M, Sauder, J.M, Wasserman, S.R, Weichert, K, Willard, F.S, Zhang, A, Emtage, S. | | 登録日 | 2012-08-22 | | 公開日 | 2012-10-17 | | 最終更新日 | 2018-11-21 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Crystal structure of the human PRMT5:MEP50 complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2XAU
 | | Crystal structure of the Prp43p DEAH-box RNA helicase in complex with ADP | | 分子名称: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | 著者 | Walbott, H, Mouffok, S, Capeyrou, R, Lebaron, S, van Tilbeurgh, H, Henry, Y, Leulliot, N. | | 登録日 | 2010-03-31 | | 公開日 | 2010-06-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Prp43P Contains a Processive Helicase Structural Architecture with a Specific Regulatory Domain.
Embo J., 29, 2010
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2X1G
 | | Crystal structure of Importin13 - Mago-Y14 complex | | 分子名称: | CADMUS, PROTEIN MAGO NASHI, RNA-BINDING PROTEIN 8A | | 著者 | Bono, F, Cook, A.G, Gruenwald, M, Ebert, J, Conti, E. | | 登録日 | 2009-12-23 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13.
Mol.Cell, 37, 2010
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3KX2
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