PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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6QFH	Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK144. 分子名称: 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, Kallikrein-6 著者 Thorpe, J.H. 登録日 2019-01-10 公開日 2019-05-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75, 2019
3LJD	The X-ray structure of zebrafish RNase1 from a new crystal form at pH 4.5 分子名称: ACETATE ION, SULFATE ION, Zebrafish RNase1 著者 Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. 登録日 2010-01-26 公開日 2010-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish. Biochem.J., 433, 2010
4YXR	CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH inhibitor. 分子名称: 3-methyl-2H-indazole, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Schiffer, A, Wendt, K.U. 登録日 2015-03-23 公開日 2015-05-27 最終更新日 2015-06-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles. Angew.Chem.Int.Ed.Engl., 54, 2015
3LNG	Crystal structure of E-cadherin EC12 AA extension 分子名称: CALCIUM ION, Cadherin-1 著者 Harrison, O, Jin, X, Shapiro, L. 登録日 2010-02-02 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Two-step adhesive binding by classical cadherins. Nat.Struct.Mol.Biol., 17, 2010
4Z84	PKAB3 in complex with pyrrolidine inhibitor 34a 分子名称: 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, METHANOL, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Lund, B.A, Alam, K.A, Engh, R.A. 登録日 2015-04-08 公開日 2015-12-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.554 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic. Chemistry, 22, 2016
3LO5	Crystal Structure of the dominant negative S17N mutant of Ras 分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Nassar, N, Singh, K, Garcia-Diaz, M. 登録日 2010-02-03 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.568 Å) 主引用文献 Structure of the Dominant Negative S17N Mutant of Ras Biochemistry, 49, 2010
3LPA	Crystal structure of a subtilisin-like protease 分子名称: Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION 著者 Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M. 登録日 2010-02-05 公開日 2010-12-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010
3LAU	Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor 分子名称: N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]butanamide, Serine/threonine-protein kinase 6 著者 Maignan, S, Guilloteau, J.P, Pouzieux, S. 登録日 2010-01-07 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
6QFF	Crystal Structure of Human Kallikrein 6 in complex with GSK144 分子名称: 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, Kallikrein-6 著者 Thorpe, J.H. 登録日 2019-01-10 公開日 2019-05-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75, 2019
6QFL	Structure of the mitogen activated kinase kinase 7 active conformation 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
8X88	The Crystal Structure of TNIK from Biortus. 分子名称: TRAF2 and NCK-interacting protein kinase 著者 Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. 登録日 2023-11-27 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Crystal Structure of TNIK from Biortus. To Be Published
4Z92	crystal structure of parechovirus-1 virion 分子名称: Capsid subunit VP3, RNA (5'-R(*AP*UP*UP*UP*UP*U)-3'), capsid subunit VP0, ... 著者 Kalynych, S, Palkova, L, Plevka, P. 登録日 2015-04-09 公開日 2015-11-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid. J.Virol., 90, 2015
3LP9	Crystal structure of LS24, A Seed Albumin from Lathyrus sativus 分子名称: CALCIUM ION, CHLORIDE ION, LS-24, ... 著者 Gaur, V, Qureshi, I.A, Singh, A, Chanana, V, Salunke, D.M. 登録日 2010-02-05 公開日 2010-02-23 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure and functional insights of hemopexin fold protein from grass pea Plant Physiol., 152, 2010
6QFT	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b 分子名称: 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
3L6Q	Crystal structure of the N-terminal domain of HSP70 from Cryptosporidium parvum (CGD2_20) 分子名称: Heat shock 70 (HSP70) protein, MAGNESIUM ION, SULFATE ION 著者 Pizarro, J.C, Wernimont, A.K, Hutchinson, A, Sullivan, H, Lew, J, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Hills, T, Structural Genomics Consortium (SGC) 登録日 2009-12-24 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structure of the N-terminal domain of HSP70 from Cryptosporidium parvum (CGD2_20) To be Published
8X5M	The Crystal Structure of JNK1 from Biortus. 分子名称: 1,2-ETHANEDIOL, 3-[4-(dimethylamino)butanoylamino]-~{N}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide, GLYCEROL, ... 著者 Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. 登録日 2023-11-17 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Crystal Structure of JNK1 from Biortus. To Be Published
4ZDZ	Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole 分子名称: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C. 登録日 2015-04-20 公開日 2016-03-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016
6QJ7	Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide 著者 Graedler, U. 登録日 2019-01-23 公開日 2020-02-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) To Be Published
8X23	The Crystal Structure of MAPK13 from Biortus. 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Mitogen-activated protein kinase 13 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Pan, W. 登録日 2023-11-09 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Crystal Structure of MAPK13 from Biortus. To Be Published
8X72	The Crystal Structure of PLK1 from Biortus. 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Wu, B. 登録日 2023-11-22 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Crystal Structure of PLK1 from Biortus. To Be Published
4ZEA	Endothiapepsin in complex with fragment B91 分子名称: 1,2-ETHANEDIOL, 2-IMINOBIOTIN, ACETATE ION, ... 著者 Huschmann, F.U, Linnik, J, Weiss, M.S, Mueller, U. 登録日 2015-04-20 公開日 2016-05-04 最終更新日 2016-05-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library. Acta Crystallogr.,Sect.F, 72, 2016
8WP9	Small-heat shock protein from Methanocaldococcus jannaschii, Hsp16.5 分子名称: Small heat shock protein HSP16.5 著者 Lee, J, Ryu, B, Kim, T, Kim, K.K. 登録日 2023-10-09 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 Cryo-EM structure of a 16.5-kDa small heat-shock protein from Methanocaldococcus jannaschii. Int.J.Biol.Macromol., 258, 2024
8WE3	Crystal structure of human FABP4 complexed with C7 分子名称: 2-[(3-chloranyl-2-phenyl-phenyl)amino]-5-fluoranyl-benzoic acid, Fatty acid-binding protein, adipocyte 著者 Xie, H, Chen, G.F, Xu, Y.C, Li, M.J. 登録日 2023-09-16 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3. Eur.J.Med.Chem., 264, 2023
6QL0	Cationic Trypsin in Complex with a D-Phe-Pro-p-aminopyridine derivative 分子名称: (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(6-azanylpyridin-3-yl)methyl]pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, CALCIUM ION, ... 著者 Ngo, K, Heine, A, Klebe, G. 登録日 2019-01-31 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.634 Å) 主引用文献 Thrombin in Complex with a D-Phe-Pro-diaminopyridine derivative To Be Published
3LB3	Two-site competitive inhibition in dehaloperoxidase-hemoglobin 分子名称: 4-chlorophenol, Dehaloperoxidase A, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 de Serrano, V.S, Franzen, S, Thompson, M.K, Davis, M.F, Nicoletti, F.P, Howes, B.D, Smulevich, G. 登録日 2010-01-07 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Internal binding of halogenated phenols in dehaloperoxidase-hemoglobin inhibits peroxidase function. Biophys.J., 99, 2010

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